Vertebrate embryo body segmentation occurs progressively along the anterior-posterior axis with the periodic formation of somites (bilaterally paired blocks of paraxial mesoderm tissue). Timely somite formation depends on an Embryo Molecular Clock (EC), evidenced by cycles of gene expression in the presomitic mesoderm (PSM). An EC has also been described in other tissues, such as the developing limb bud, however with very different periodicity, raising a fundamental question: How is the temporal control of gene expression achieved in the EC? The hypothesis we are addressing is that microRNAs present in distinct tissues impact EC mRNA stability, accounting for the different oscillation periods observed.  

When?

Wednesday I 28 November I 13:30

Where?

Room 2.31 I Building 7 I Gambelas Campus

About our speaker:

Isabel Duarte is a bioinformatics researcher at CBMR since 2014. Isabel has a PhD in Medical Sciences from Radboud Universiteit (Netherlands) and holds a master degree in oncology from Universidade do Porto. Currently, she is interested in timing cell differentiation.

This seminar was kindly sponsored by: