In Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes. | - CCMAR -

Journal Article

TitleIn Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes.
Publication TypeJournal Article
AuthorsCortes, S, Albuquerque, A, Cabral, LIL, Lopes, L, Campino, L, Cristiano, MLS
Year of Publication2015
JournalAntimicrob Agents Chemother
Volume59
Issue8
Date Published2015 Aug
Pagination5032-5
ISSN1098-6596
KeywordsAntiparasitic Agents, Artemisinins, Cell Proliferation, Drug Resistance, Multiple, Heterocyclic Compounds, 1-Ring, Humans, Leishmania infantum, Leishmaniasis, Macrophages, Parasitic Sensitivity Tests, Spiro Compounds
Abstract

Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.
DOI10.1128/AAC.00298-15
Sapientia

http://www.ncbi.nlm.nih.gov/pubmed/26014947?dopt=Abstract
Alternate JournalAntimicrob. Agents Chemother.
PubMed ID26014947
PubMed Central IDPMC4505222
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