Journal Article
| Título | Novel bioactive parathyroid hormone and related peptides in teleost fish. |
| Publication Type | Journal Article |
| Authors | Canario, AVM, Rotllant, J, Fuentes, J, Guerreiro, PM, Teodósio, R, Power, DM, Clark, MS |
| Year of Publication | 2006 |
| Journal | FEBS Lett |
| Volume | 580 |
| Questão | 1 |
| Date Published | 2006 Jan 9 |
| Pagination | 291-9 |
| ISSN | 0014-5793 |
| Palavras-chave | Amino Acid Sequence, Animals, Gene Expression Regulation, Molecular Sequence Data, Parathyroid Hormone, Phylogeny, Takifugu |
| Abstract | We report the identification, gene expression and biological activity of two parathyroid hormones (PTH; PTHA and PTHB), two PTH-related peptides (PTHrP; PTHrPA and PTHrPB) and a PTH-like ligand (PTH-L) with hybrid characteristics in puffer fishes (Takifugu rubripes and Tetraodon fluviatilis). Experimental data are consistent with PTH-L and PTHrPA having calciotropic activities equivalent, respectively, to tetrapod PTH and PTHrP. We hypothesise on the basis of phylogenetic and functional analysis that PTH-L could be a fish relic of an ancestral PTH/PTHrP gene. |
| DOI | 10.1016/j.febslet.2005.12.023 |
| Sapientia | |
| Alternate Journal | FEBS Lett. |
| PubMed ID | 16376340 |
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