Journal Article
Title | Synthetic versus natural receptors: supramolecular control of chemical sensing in fish. |
Publication Type | Journal Article |
Authors | da Silva, JPaulo, Choudhury, R, Porel, M, Pischel, U, Jockusch, S, Hubbard, PC, Ramamurthy, V, Canario, AVM |
Year of Publication | 2014 |
Journal | ACS Chem Biol |
Volume | 9 |
Issue | 7 |
Date Published | 2014 Jul 18 |
Pagination | 1432-6 |
ISSN | 1554-8937 |
Keywords | Adamantane, Animals, Bridged Compounds, Cadaverine, Female, Imidazoles, Male, Models, Molecular, Receptors, Odorant, Smell, Tilapia |
Abstract | The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction. |
DOI | 10.1021/cb500172u |
Sapientia | |
Alternate Journal | ACS Chem. Biol. |
PubMed ID | 24841288 |