Synthetic versus natural receptors: supramolecular control of chemical sensing in fish. | - CCMAR -

Journal Article

TitleSynthetic versus natural receptors: supramolecular control of chemical sensing in fish.
Publication TypeJournal Article
Authorsda Silva, JPaulo, Choudhury, R, Porel, M, Pischel, U, Jockusch, S, Hubbard, PC, Ramamurthy, V, Canario, AVM
Year of Publication2014
JournalACS Chem Biol
Volume9
Issue7
Date Published2014 Jul 18
Pagination1432-6
ISSN1554-8937
KeywordsAdamantane, Animals, Bridged Compounds, Cadaverine, Female, Imidazoles, Male, Models, Molecular, Receptors, Odorant, Smell, Tilapia
Abstract

The encapsulation of odorants by the synthetic receptor cucurbit[7]uril (CB[7]) reduces the response of olfactory receptors in Mozambique tilapia (Oreochromis mossambicus) in vivo. For example, the olfactory receptor response to the odorant adamantan-1-amine, as measured by electro-olfactography, was suppressed by 92% in the presence of CB[7]. A reduction in olfactory response of 88% was observed for pentane-1,5-diamine (cadaverine), an odorant associated with carrion avoidance in some fish. The results reveal how the association constants and the concentrations of natural and synthetic receptors play a determinant role and show that synthetic receptors can be used to remove bioactive molecules from fish olfaction.

DOI10.1021/cb500172u
Sapientia

http://www.ncbi.nlm.nih.gov/pubmed/24841288?dopt=Abstract

Alternate JournalACS Chem. Biol.
PubMed ID24841288