Journal Article
| Title | Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus. |
| Publication Type | Journal Article |
| Authors | Cardoso, JCR, Laiz-Carrion, R, Louro, B, Silva, N, Canario, AVM, Mancera, JMiguel, Power, DM |
| Year of Publication | 2011 |
| Journal | Gen Comp Endocrinol |
| Volume | 173 |
| Issue | 3 |
| Date Published | 2011 Sep 15 |
| Pagination | 396-404 |
| ISSN | 1095-6840 |
| Keywords | Amino Acid Sequence, Animals, Brain, Cloning, Molecular, Fish Proteins, Gene Duplication, Molecular Sequence Data, Phylogeny, Pituitary Gland, Pro-Opiomelanocortin, Sea Bream, Sequence Alignment, Sequence Analysis, Protein |
| Abstract | Proopiomelanocorticotrophin (POMC) in vertebrates is produced in the pituitary gland and undergoes post-translational processing to give rise to a range of biologically active peptides. Teleosts possess 2-3 different POMC transcripts which have been proposed to have originated from a whole or partial genome duplication. In the present study 2 transcripts of gilthead sea bream POMC (sbPOMC-α1 and α2) were cloned and characterised. sbPOMC-α1 is expressed principally in the melanotroph cells of the pars intermedia (PI) and sbPOMC-α2 is expressed in the corticotroph cells of the rostral pars distalis and probably also in the PI. The 2 sbPOMC transcripts have a differential tissue distribution in extra-pituitary sites. An appraisal of POMC evolution indicates sbPOMCs belong to one of the two main clades that exist in teleosts and that overall a non conservative process of gene loss occurred in this infraclass. |
| DOI | 10.1016/j.ygcen.2010.12.001 |
| Sapientia | |
| Alternate Journal | Gen. Comp. Endocrinol. |
| PubMed ID | 21147111 |
