Biochemistry and molecular biology in Portugal: an overview of past and current contributions.

Ana A Ramos; João Varela; Teles, Licia Marlene; Ana A Ramos; Henriques, Nuno Miguel; M. Leonor Cancela; João Varela; Brenig, Bertram; João Varela; Furota, S.; Grunert, P.; Hodell, D.; Jimenez-Espejo, F.; Kim, J. K.; Krissek, L.; Kuroda, J.; Li, B.; Llave, E.; Lofi, J.; Lourens, L.; Miller, M.; Nanayama, F.; Nishida, N.; Richter, C.; Roque, C.; Hugo Pereira; Sanchez Goni, M. F.; Sierro, F. J.; Singh, A. D.; Sloss, C.; Takashimizu, Y.; Tzanova, A.; Antje H. L. Voelker; Williams, T.; Xuan, C.

Marine Biotechnology

Short Title

MarBiotech

Descrição

Coordenador

João Varela

Organiza

Sobre

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The Marine Biotechnology research group is currently ongoing active research in different fields of microalgal biotechnology, as well as in the exploitation of different marine organisms as sources of novel bioactive compounds. In addition, the group uses structure-based design for lead optimisation with the final goal of obtaining novel drugs to fight human and animal disease.

The MarBiotech research group is focused on the following interrelated research lines:

- Algae biofuels.

- Molecular basis of carotenoid biosynthesis in microalgae.

- Isolation of carotenoid- and lipid-hyperproducing microalgal strains.

- LEDs for microalgal production.

- Marine innovative feeds and functional foods.

- Marine bioactive compounds.

- Drug lead development and optimisation.

News

Especialistas do CCMAR vão otimizar produção e utilização de microalgas

New on Board: Chloé Placines

Três investigadoras do CCMAR receberam prémios Tech2Market

NEW ON BOARD: Etiele Morais

New MSc Student: Ricardo Cerqueira

New MSc Student: Gabriel Bombo

Girl Power: inspirando duas jovens investigadoras

Investigadores do grupo MarBiotech participaram na conferência EUROCAROTEN

Investigadores do CCMAR participaram no congresso ALGAEUROPE

Workshop Algas foi um sucesso

Qual será o impacto do COVID-19 no Ambiente em 2040?

Quais os benefícios da utilização de LEDs na produção de microalgas?

Membros

Enroll

Ver em tabela

Nome	Posição
Carolina	Investigador
Carolina Amaral Frade Bruno de Sousa
Chloé Placines
Filipa Pinheiro	PhD Student
Hugo Galvão Caiano Pereira
João Varela	Investigador
Lisa Schueler	PhD Student
Luísa Barreira	Senior Researcher
Marta Oliveira
Nadpi Gangadhar Katkam
Pedro Filipe Castela Horta
Peter Simon Claus Schulze

Ver em grelha

Carolina

Posição:

Investigador

Carolina Amaral Frade Bruno de Sousa

Posição:

Chloé Placines

Posição:

Filipa Pinheiro

Posição:

PhD Student

Hugo Galvão Caiano Pereira

Posição:

João Varela

Posição:

Investigador

Lisa Schueler

Posição:

PhD Student

Luísa Barreira

Posição:

Senior Researcher

Marta Oliveira

Posição:

Nadpi Gangadhar Katkam

Posição:

Pedro Filipe Castela Horta

Posição:

Peter Simon Claus Schulze

Posição:

Galeria

Publicações

Todas publicações


Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea (Camellia sinensis) and rooibos tisane (Aspalathus linearis). Journal of Pharmaceutical and Biomedical Analysis. 2017;145. doi:10.1016/j.jpba.2017.07.007 Ler mais acerca de Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea (Camellia sinensis) and rooibos tisane (Aspalathus linearis) Google Scholar DOI
Rodrigues MJoão, Neves V, Martins A, et al. In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Food Chem. 2016;200:322-9. doi:10.1016/j.foodchem.2016.01.048 Ler mais acerca de In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Google Scholar PubMed DOI
Custódio L, Laukaityte S, Engelen AH, et al. A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal. Natural Product Research. 2016;30(6):724 - 728. doi:10.1080/14786419.2015.1040791 Ler mais acerca de A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal Google Scholar DOI
Oliveira M, Junior PAdemar Sal, Rodrigues MJoão, et al. Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Asian Pac J Trop Med. 2016;9(8):735-41. doi:10.1016/j.apjtm.2016.06.015 Ler mais acerca de Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Google Scholar PubMed DOI
Ismael A, Henriques MSC, Marques C, et al. Exploring saccharinate-tetrazoles as selective Cu(. RSC Adv. 2016;6(75):71628 - 71637. doi:10.1039/C6RA15051A Ler mais acerca de Exploring saccharinate-tetrazoles as selective Cu( Google Scholar DOI
Pereira H, Custódio L, Rodrigues MJ, et al. Profiling of antioxidant potential and phytoconstituents of Plantago coronopus. Brazilian Journal of Biology. 2016;(ahead). doi:10.1590/1519-6984.02416 Ler mais acerca de Profiling of antioxidant potential and phytoconstituents of Plantago coronopus Google Scholar DOI
Grosso C, Cardoso ALúcia, Lemos A, et al. Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Eur J Med Chem. 2015;93:9-15. doi:10.1016/j.ejmech.2015.01.050 Ler mais acerca de Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Google Scholar PubMed DOI
Vizetto-Duarte C, Pereira H, de Sousa CBruno, et al. Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective. Nat Prod Res. 2015;29(13):1264-70. doi:10.1080/14786419.2014.992343 Ler mais acerca de Fatty acid profile of different species of algae of the Cystoseira genus: a nutraceutical perspective. Google Scholar PubMed DOI
Pereira H, Custódio L, Rodrigues MJoão, et al. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar Drugs. 2015;13(6):3531-49. doi:10.3390/md13063531 Ler mais acerca de Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Google Scholar PubMed DOI
Rodrigues MJoão, Gangadhar KN, Vizetto-Duarte C, et al. Maritime halophyte species from southern Portugal as sources of bioactive molecules. Mar Drugs. 2014;12(4):2228-44. doi:10.3390/md12042228 Ler mais acerca de Maritime halophyte species from southern Portugal as sources of bioactive molecules. Google Scholar PubMed DOI
Hernandez-Molina FJ, Stow DAV, Alvarez-Zarikian CA, et al. Onset of Mediterranean outflow into the North Atlantic. Science. 2014;344(6189):1244 - 1250. doi:10.1126/science.1251306 Ler mais acerca de Onset of Mediterranean outflow into the North Atlantic Google Scholar DOI
Schulze PSC, Barreira L, Pereira H, Perales JA, Varela J. Light emitting diodes (LEDs) applied to microalgal production. Trends Biotechnol. 2014;32(8):422-30. doi:10.1016/j.tibtech.2014.06.001 Ler mais acerca de Light emitting diodes (LEDs) applied to microalgal production. Google Scholar PubMed DOI
Martins DAlves, Custódio L, Barreira L, et al. Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. Mar Drugs. 2013;11(7):2259-81. doi:10.3390/md11072259 Ler mais acerca de Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. Google Scholar PubMed DOI
Maria VL, Gomes T, Barreira L, Bebianno MJ. Impact of benzo(a)pyrene, Cu and their mixture on the proteomic response of Mytilus galloprovincialis. Aquat Toxicol. 2013;144-145:284-95. doi:10.1016/j.aquatox.2013.10.009 Ler mais acerca de Impact of benzo(a)pyrene, Cu and their mixture on the proteomic response of Mytilus galloprovincialis. Google Scholar PubMed DOI
Hernández-Prieto MA, Schön V, Georg J, et al. Iron deprivation in Synechocystis: inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling. G3 (Bethesda). 2012;2(12):1475-95. doi:10.1534/g3.112.003863 Ler mais acerca de Iron deprivation in Synechocystis: inference of pathways, non-coding RNAs, and regulatory elements from comprehensive expression profiling. Google Scholar PubMed DOI
Pereira H, Barreira L, Figueiredo F, et al. Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. Mar Drugs. 2012;10(9):1920-35. doi:10.3390/md10091920 Ler mais acerca de Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications. Google Scholar PubMed DOI
Pereira H, Barreira L, Mozes A, et al. Microplate-based high throughput screening procedure for the isolation of lipid-rich marine microalgae. Biotechnol Biofuels. 2011;4(1):61. doi:10.1186/1754-6834-4-61 Ler mais acerca de Microplate-based high throughput screening procedure for the isolation of lipid-rich marine microalgae. Google Scholar PubMed DOI
Ramos AA, Marques AR, Rodrigues M, et al. Molecular and functional characterization of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Dunaliella salina. J Plant Physiol. 2009;166(9):968-77. doi:10.1016/j.jplph.2008.11.008 Ler mais acerca de Molecular and functional characterization of a cDNA encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase from Dunaliella salina. Google Scholar PubMed DOI
Ramos AA, Coesel S, Marques A, et al. Isolation and characterization of a stress-inducible Dunaliella salina Lcy-beta gene encoding a functional lycopene beta-cyclase. Appl Microbiol Biotechnol. 2008;79(5):819-28. doi:10.1007/s00253-008-1492-4 Ler mais acerca de Isolation and characterization of a stress-inducible Dunaliella salina Lcy-beta gene encoding a functional lycopene beta-cyclase. Google Scholar PubMed DOI
Coesel SNicole, Baumgartner ACordeiro, Teles LMarlene, et al. Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress. Mar Biotechnol (NY). 2008;10(5):602-11. doi:10.1007/s10126-008-9100-2 Ler mais acerca de Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress. Google Scholar PubMed DOI
Ramos AA, Varela J. Biochemistry and molecular biology in Portugal: an overview of past and current contributions. IUBMB Life. 2008;60(5):265-9. doi:10.1002/iub.65 Ler mais acerca de Biochemistry and molecular biology in Portugal: an overview of past and current contributions. Google Scholar PubMed DOI

Projetos

	Título do Projeto	Coordenador	Período	Financiamento	CCMAR	Total
RHE-MEDiation	RHE-MEDiation - Responsive hub for long term governance to destress the Mediterranean Sea from chemical pollution.	Luísa Barreira	01/06/2023 a 31/05/2026	Comissão Europeia		521.645,00k€
Vertical Algas	PRR: Pacto Bioeconomia Azul - Vertical Algas (WP 5)	João Varela, Ester Serrão, Rui Santos	01/07/2022 a 31/12/2025	IAPMEI
GreenTreat	GreenTreat: An Integrated, Sustainable Process for the Tertiary Treatment of Urban Wastewater using Microalgae in the Algarve region	Luísa Barreira	28/09/2018 a 31/05/2022	FCT	155.00k€	236,46k€

	Título do Projeto	Coordenador	Período	Financiamento	CCMAR
SEAWEED	Anaerobic Digestion of Seaweed for Biofuels	João Varela	01/09/2011 a 31/08/2013	Comissão Europeia	211.19k€
CYANO	Regulação da homeostase do ferro em cianobactérias	João Varela	01/01/2010 a 30/06/2013	FCT	42.62k€
BOTRYOFUEL	Microalgas hiperprodutoras de hidrocarbonetos	João Varela	01/07/2007 a 30/06/2008	AdI - Agência de Inovação	12.31k€

Notícias

News

Girl Power: inspirando duas jovens investigadoras

As girls movers, Cláudia e Isilda, vieram conhecer mulheres que as inspiram na área das ciências marinhas e conhecer o trabalho desenvolvido pelas investigadoras do CCMAR.

Workshop Algas foi um sucesso

Neste evento, foram apresentados o papel das empresas produtoras de microalgas, novas estratégias de produção de microalgas desenvolvidas no LNEG, o conceito de biorrefinaria de biomassa algal e duas mesas redondas.

Investigadores do grupo MarBiotech participaram na conferência EUROCAROTEN

Nos passados dias 26-28 de novembro, a aluna de doutoramento Lisa Schüler e o investigador Gangadhar Katkam , do grupo MarBiotech , participaram na conferência EUROCAROTEN, que decorreu no Chipre.

Investigadores do CCMAR participaram no congresso ALGAEUROPE

Ao longo dos três dias de congresso, os nossos investigadores fizeram várias apresentações orais e apresentaram os seus posters.

Qual será o impacto do COVID-19 no Ambiente em 2040?

Isabel Marín Beltrán, investigadora do CCMAR, foi uma das jovens cientistas convidadas pela Science para escrever sobre como imaginam o mundo em 2040, considerando o possível impacto do COVID-19.

Quais os benefícios da utilização de LEDs na produção de microalgas?

Os nossos investigadores descobriram que a utilização de LEDs na produção de microalgas em tanques exteriores aumenta o crescimento da sua biomassa, principalmente durante a noite.