In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers&#039; infusions and decoctions: A comparison with green tea (Camellia sinensis).

Rodrigues, Maria João; Neves, Vanessa; Martins, Alice; Rauter, Amélia P; Neng, Nuno R; Nogueira, José M F; João Varela; Luísa Barreira; Luísa Custódio; Mouffouk, Fouzi; Abu-Salah, Khalid M; Ben-Hamadou, Radhouan; João Varela; Gaspar, Maria Manuela; Reis, Catarina Pinto

Maria João Rodrigues

Position

Researcher

Academic Degree

Doutoramento

Group

XtremeBio

Professor Category

Invited

Institution

University of Algarve

Based at

Faro, Gambelas Campus, UAlg

Office Nr

Lab 3.31 - Ed. 2

Extension

7465

mjrodrigues@ualg.pt

ORCID ID

ResearchGate

Organiza

Main Info

Maria has a degree in Biology from the University of Algarve (UAlg), Portugal, in 2006. She furthered her education with a master's in Biomedical Sciences in 2012 and a PhD in Biological Sciences with a specialization in Biotechnology, both from UAlg, concluding in 2019. Her research has significantly advanced the fields of blue biotechnology and saline agriculture, underscored by her role in 9 national R&D initiatives, an international PRIMA project, and 3 COST actions, showcasing her extensive collaboration and impact in these specialized areas. In 2018, alongside Luísa Custódio, Maria co-founded the "XtremeBio" research group at CCMAR, focusing on innovative uses of halophytes as sources of high-value products, and phytoremediation uses underlining her commitment to sustainable biotechnology solutions. Her expertise and dedication were recognised in 2022 when CCMAR hired her as a Junior Researcher through the FCT Contract Programme (UIDP/04326/2020), specifically for her project "Halo-In: How can tissue culture be used for biodiversity preservation and biotechnological valorisation of selected salt tolerant species from the Algarve coast”. Maria has also made significant editorial contributions serving as a guest editor for specialized issues in her field. Currently, she teaches in the "Sustainable bioprospecting of natural products" unit of the IMBRSea international master's program. The outcomes of her innovative experiments have not only bolstered her career but also contributed to the broader scientific community, with the XtremeBio research group's findings disseminated through 81 papers in peer-reviewed international journals, 14 conference proceedings, a book chapter, 37 conference presentations, and 11 invited talks. This output demonstrates Maria's passion for science and her substantial influence on plant and environmental biotechnology.

Publications

Selected Publications

Rodrigues MJoão, Gangadhar KN, Vizetto-Duarte C, et al. Maritime halophyte species from southern Portugal as sources of bioactive molecules. Mar Drugs. 2014;12(4):2228-44. doi:10.3390/md12042228

Rodrigues MJoão, Neves V, Martins A, et al. In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Food Chem. 2016;200:322-9. doi:10.1016/j.foodchem.2016.01.048

Publications

Year of Publication
2023	Rodrigues MJoão, Pereira CGuerreiro, Oliveira M, Zengin G, Custódio L. Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review. Marine Drugs. 2023;21(2):66. doi:10.3390/md21020066 Read more about Salt-Tolerant Plants as Sources of Antiparasitic Agents for Human Use: A Comprehensive Review Google Scholar PT DOI
2023	Bendjedou H, Benamar H, Bennaceur M, et al. New Insights into the Phytochemical Profile and Biological Properties of Lycium intricatum Bois. (Solanaceae). Plants. 2023;12(5):996. doi:10.3390/plants12050996 Read more about New Insights into the Phytochemical Profile and Biological Properties of Lycium intricatum Bois. (Solanaceae) Google Scholar PT DOI
2022	Rodrigues MJoão, Custódio L, Mecha D, et al. Nutritional and Phyto-Therapeutic Value of the Halophyte Cladium mariscus L. (Pohl.): A Special Focus on Seeds. Plants. 2022;11(21):2910. doi:10.3390/plants11212910 Read more about Nutritional and Phyto-Therapeutic Value of the Halophyte Cladium mariscus L. (Pohl.): A Special Focus on Seeds Google Scholar PT DOI
2022	Rodrigues MJoão, Jekő J, Cziáky Z, Pereira CG, Custódio L. The Medicinal Halophyte Frankenia laevis L. (Sea Heath) Has In Vitro Antioxidant Activity, α-Glucosidase Inhibition, and Cytotoxicity towards Hepatocarcinoma Cells. Plants. 2022;11(10):1353. doi:10.3390/plants11101353 Read more about The Medicinal Halophyte Frankenia laevis L. (Sea Heath) Has In Vitro Antioxidant Activity, α-Glucosidase Inhibition, and Cytotoxicity towards Hepatocarcinoma Cells Google Scholar PT DOI
2022	Youssef S, Custódio L, Rodrigues MJoão, et al. Nutritional anti-nutritional chemical composition and antioxidant activities of the leaves of the sea cliff dwelling species Limonium spathulatum (Desf.) Kuntze. Frontiers in Plant Science. 2022;13. doi:10.3389/fpls.2022.979343 Read more about Nutritional anti-nutritional chemical composition and antioxidant activities of the leaves of the sea cliff dwelling species Limonium spathulatum (Desf.) Kuntze Google Scholar PT DOI
2022	Custódio L, Slusarczyk S, Matkowski A, et al. A first approach for the micropropagation of the medicinal halophyte Polygonum maritimum L. and phenolic profile of acclimatized plants. Frontiers in Plant Science. 2022;13. doi:10.3389/fpls.2022.960306 Read more about A first approach for the micropropagation of the medicinal halophyte Polygonum maritimum L. and phenolic profile of acclimatized plants Google Scholar PT DOI
2021	Pereira CG, Moraes CBorsoi, Franco CH, et al. In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.). Plants. 2021;10(11):2235. doi:10.3390/plants10112235 Read more about In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.) Google Scholar PT DOI
2021	Rukavina I, Rodrigues MJoão, Pereira CG, et al. Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L. Molecules. 2021;26(20):6136. doi:10.3390/molecules26206136 Read more about Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L. Google Scholar PT DOI
2021	Pan Y-L, Rodrigues MJoão, Pereira CG, et al. Exploring the Biotechnological Value of Marine Invertebrates: A Closer Look at the Biochemical and Antioxidant Properties of Sabella spallanzanii and Microcosmus squamiger. Animals. 2021;11(12):3557. doi:10.3390/ani11123557 Read more about Exploring the Biotechnological Value of Marine Invertebrates: A Closer Look at the Biochemical and Antioxidant Properties of Sabella spallanzanii and Microcosmus squamiger Google Scholar PT DOI
2021	Custódio L, Rodrigues MJoão, Pereira CG, et al. A Review on Sarcocornia Species: Ethnopharmacology, Nutritional Properties, Phytochemistry, Biological Activities and Propagation. Foods. 2021;10(11):2778. doi:10.3390/foods10112778 Read more about A Review on Sarcocornia Species: Ethnopharmacology, Nutritional Properties, Phytochemistry, Biological Activities and Propagation Google Scholar PT DOI
2021	Yaagoubi MEl, Mechqoq H, Ortiz S, et al. Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae). Chemistry & Biodiversity. 2021;18(12). doi:10.1002/cbdv.v18.1210.1002/cbdv.202100653 Read more about Chemical Composition and Biological Screening of the Essential Oils of Micromeria macrosiphon and M. arganietorum (Lamiaceae) Google Scholar PT DOI
2021	Rodrigues MJoão, Castañeda-Loaiza V, Monteiro I, et al. Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives. Foods. 2021;10(12):3104. doi:10.3390/foods10123104 Read more about Metabolomic Profile and Biological Properties of Sea Lavender (Limonium algarvense Erben) Plants Cultivated with Aquaculture Wastewaters: Implications for Its Use in Herbal Formulations and Food Additives Google Scholar PT DOI
2020	Castañeda-Loaiza V, Placines C, Rodrigues MJoão, et al. If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products. Industrial Crops and Products. 2020;144:112005. doi:10.1016/j.indcrop.2019.112005 Read more about If you cannot beat them, join them: Exploring the fruits of the invasive species Carpobrotus edulis (L.) N.E. Br as a source of bioactive products Google Scholar PT DOI
2020	Castañeda-Loaiza V, Placines C, Rodrigues MJoão, et al. In vitro enzyme inhibitory and anti-oxidant properties, cytotoxicity and chemical composition of the halophyte Malcolmia littorea (L.) R.Br. (Brassicaceae). Natural Product Research. 2020:1 - 4. doi:10.1080/14786419.2020.1719484 Read more about In vitro enzyme inhibitory and anti-oxidant properties, cytotoxicity and chemical composition of the halophyte Malcolmia littorea (L.) R.Br. (Brassicaceae) Google Scholar PT DOI
2020	Gangadhar KN, Rodrigues MJoão, Pereira H, et al. Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea. Marine Drugs. 2020;18(11):567. doi:10.3390/md18110567 Read more about Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea Google Scholar PT DOI
2020	Mota AHenriques, Andrade JM, Rodrigues MJoão, et al. Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses. Industrial Crops and Products. 2020;154:112709. doi:10.1016/j.indcrop.2020.112709 Read more about Synchronous insight of in vitro and in vivo biological activities of Sambucus nigra L. extracts for industrial uses Google Scholar PT DOI
2020	Rodrigues MJoão, Monteiro I, Castañeda-Loaiza V, et al. Growth performance, in vitro antioxidant properties and chemical composition of the halophyte Limonium algarvense Erben are strongly influenced by the irrigation salinity. Industrial Crops and Products. 2020;143:111930. doi:10.1016/j.indcrop.2019.111930 Read more about Growth performance, in vitro antioxidant properties and chemical composition of the halophyte Limonium algarvense Erben are strongly influenced by the irrigation salinity Google Scholar PT DOI
2020	Trentin R, Custódio L, Rodrigues MJoão, et al. Exploring Ulva australis Areschoug for possible biotechnological applications: In vitro antioxidant and enzymatic inhibitory properties, and fatty acids contents. Algal Research. 2020;50:101980. doi:10.1016/j.algal.2020.101980 Read more about Exploring Ulva australis Areschoug for possible biotechnological applications: In vitro antioxidant and enzymatic inhibitory properties, and fatty acids contents Google Scholar PT DOI
2020	Zengin G, Sinan KIbrahime, Ak G, et al. Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study. Industrial Crops and Products. 2020;153:112572. doi:10.1016/j.indcrop.2020.112572 Read more about Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study Google Scholar PT DOI
2019	Dra LAit, Rodrigues MJoão, Neng Nda Rosa, et al. Exploring Caralluma europaea (Guss.) N.E.Br. as a potential source of bioactive molecules: In vitro antioxidant and antidiabetic properties, and phenolic profile of crude extracts and fractions. Industrial Crops and Products. 2019;139:111527. doi:10.1016/j.indcrop.2019.111527 Read more about Exploring Caralluma europaea (Guss.) N.E.Br. as a potential source of bioactive molecules: In vitro antioxidant and antidiabetic properties, and phenolic profile of crude extracts and fractions Google Scholar PT DOI
2019	Mota AHenriques, Direito R, Carrasco MP, et al. Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis. International Journal of Pharmaceutics. 2019;559:13 - 22. doi:10.1016/j.ijpharm.2019.01.017 Read more about Combination of hyaluronic acid and PLGA particles as hybrid systems for viscosupplementation in osteoarthritis Google Scholar PT DOI
2019	Rodrigues MJoão, Matkowski A, Slusarczyk S, et al. Sea knotgrass (Polygonum maritimum L.) as a potential source of innovative industrial products for skincare applications. Industrial Crops and Products. 2019;128:391 - 398. doi:10.1016/j.indcrop.2018.11.038 Read more about Sea knotgrass (Polygonum maritimum L.) as a potential source of innovative industrial products for skincare applications Google Scholar PT DOI
2019	Rodrigues MJoão, Monteiro I, Placines C, et al. Dataset on functional and chemical properties of the medicinal halophyte Polygonum maritimum L. under greenhouse cultivation. Data in Brief. 2019;25:104357. doi:10.1016/j.dib.2019.104357 Read more about Dataset on functional and chemical properties of the medicinal halophyte Polygonum maritimum L. under greenhouse cultivation Google Scholar PT DOI
2019	Rodrigues MJoão, Monteiro I, Placines C, et al. The irrigation salinity and harvesting affect the growth, chemical profile and biological activities of Polygonum maritimum L. Industrial Crops and Products. 2019;139:111510. doi:10.1016/j.indcrop.2019.111510 Read more about The irrigation salinity and harvesting affect the growth, chemical profile and biological activities of Polygonum maritimum L. Google Scholar PT DOI
2019	Trampetti F, Pereira C, Rodrigues MJoão, et al. Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies. Journal of Pharmaceutical and Biomedical Analysis. 2019;165:119 - 128. doi:10.1016/j.jpba.2018.11.053 Read more about Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies Google Scholar PT DOI
2019	Vizetto-Duarte C, Figueiredo F, Rodrigues MJoão, Polo C, Rešek E, Custódio L. Sustainable Valorization of Halophytes from the Mediterranean Area: A Comprehensive Evaluation of Their Fatty Acid Profile and Implications for Human and Animal Nutrition. Sustainability. 2019;11(8):2197. doi:10.3390/su11082197 Read more about Sustainable Valorization of Halophytes from the Mediterranean Area: A Comprehensive Evaluation of Their Fatty Acid Profile and Implications for Human and Animal Nutrition Google Scholar PT DOI
2019	Zengin G, Mahomoodally MFawzi, Paksoy MYavuz, et al. Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients. Industrial Crops and Products. 2019;135:107 - 121. doi:10.1016/j.indcrop.2019.04.033 Read more about Phytochemical characterization and bioactivities of five Apiaceae species: Natural sources for novel ingredients Google Scholar PT DOI
2019	Zengin G, Paksoy MYavuz, Aumeeruddy MZakariyyah, et al. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food Research International. 2019;123:414 - 424. doi:10.1016/j.foodres.2019.05.013 Read more about New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species Google Scholar PT DOI
2019	Zengin G, Stefanucci A, Rodrigues MJoão, et al. Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles. Journal of Pharmaceutical and Biomedical Analysis. 2019;162:225 - 233. doi:10.1016/j.jpba.2018.09.035 Read more about Scrophularia lucida L. as a valuable source of bioactive compounds for pharmaceutical applications: In vitro antioxidant, anti-inflammatory, enzyme inhibitory properties, in silico studies, and HPLC profiles Google Scholar PT DOI
2018	González-Wangüemert M, Roggatz CC, Rodrigues MJoão, Barreira L, da Silva MMoreira, Custódio L. A new insight into the influence of habitat on the biochemical properties of three commercial sea cucumber species. International Aquatic Research. 2018;10(4):361 - 373. doi:10.1007/s40071-018-0210-9 Read more about A new insight into the influence of habitat on the biochemical properties of three commercial sea cucumber species Google Scholar PT DOI
2018	Rodrigues MJoão, Slusarczyk S, Pecio Ł, et al. In vitro and in silico approaches to appraise Polygonum maritimum L. as a source of innovative products with anti-ageing potential. Industrial Crops and Products. 2018;111:391 - 399. doi:10.1016/j.indcrop.2017.10.046 Read more about In vitro and in silico approaches to appraise Polygonum maritimum L. as a source of innovative products with anti-ageing potential Google Scholar DOI
2018	Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp. maritima: from traditional remedies to prospective products. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-23038-6 Read more about Health promoting potential of herbal teas and tinctures from Artemisia campestris subsp. maritima: from traditional remedies to prospective products Google Scholar PT DOI
2018	Rodrigues MJoão, Vizetto-Duarte C, Gangadhar KN, et al. In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells. Pharmacological Reports. 2018;70(5):896 - 899. doi:10.1016/j.pharep.2018.02.001 Read more about In vitro and in silico approaches to unveil the mechanisms underlying the cytotoxic effect of juncunol on human hepatocarcinoma cells Google Scholar PT DOI
2018	Roggatz CC, González-Wangüemert M, Pereira H, et al. A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain). Natural Product Research. 2018;32(1):116 - 120. doi:10.1080/14786419.2017.1331224 Read more about A first glance into the nutritional properties of the sea cucumber Parastichopus regalis from the Mediterranean Sea (SE Spain) Google Scholar PT DOI
2018	Zengin G, Rodrigues MJoão, Abdallah HH, et al. Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey. Computational Biology and Chemistry. 2018;77:178 - 186. doi:10.1016/j.compbiolchem.2018.10.005 Read more about Combination of phenolic profiles, pharmacological properties and in silico studies to provide new insights on Silene salsuginea from Turkey Google Scholar PT DOI
2017	Braga T, Rodrigues MJoão, Pereira H, et al. Bursatella leachii from Mar Menor as a Source of Bioactive Molecules: Preliminary Evaluation of the Nutritional Profile, In Vitro Biological Activities, and Fatty Acids Contents. Journal of Aquatic Food Product Technology. 2017;26(10):1337 - 1350. doi:10.1080/10498850.2017.1392670 Read more about Bursatella leachii from Mar Menor as a Source of Bioactive Molecules: Preliminary Evaluation of the Nutritional Profile, In Vitro Biological Activities, and Fatty Acids Contents Google Scholar PT DOI
2017	Grosso C, Cardoso AL, Rodrigues MJoão, et al. Hetero-Diels-Alder approach to Bis(indolyl)methanes. Bioorganic & Medicinal Chemistry. 2017;25(3):1122 - 1131. doi:10.1016/j.bmc.2016.12.028 Read more about Hetero-Diels-Alder approach to Bis(indolyl)methanes Google Scholar PT DOI
2017	Pereira CGuerreiro, Barreira L, Bijttebier S, et al. Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea ( Camellia sinensis ) and rooibos tisane ( Aspalathus linearis ). Journal of Pharmaceutical and Biomedical Analysis. 2017;145:593 - 603. doi:10.1016/j.jpba.2017.07.007 Read more about Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea ( Camellia sinensis ) and rooibos tisane ( Aspalathus linearis ) Google Scholar DOI
2017	Lopes SMM, Sousa EP, Barreira L, Marques C, Rodrigues MJoão, Melo TMVDPin. Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5- a ]pyridine-fused steroids. Steroids. 2017;122:16 - 23. doi:10.1016/j.steroids.2017.03.006 Read more about Synthesis and anti-cancer activity of chiral tetrahydropyrazolo[1,5- a ]pyridine-fused steroids Google Scholar PT DOI
2017	Rodrigues MJoão, Gangadhar KN, Zengin G, et al. Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies. Food and Chemical Toxicology. 2017;107:590 - 596. doi:10.1016/j.fct.2017.04.006 Read more about Juncaceae species as sources of innovative bioactive compounds for the food industry: In vitro antioxidant activity, neuroprotective properties and in silico studies Google Scholar PT DOI
2017	Rodrigues MJoão, Custódio L, Lopes A, et al. Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum. Pharmaceutical Biology. 2017;55(1):1348 - 1357. doi:10.1080/13880209.2017.1301493 Read more about Unlocking the in vitro anti-inflammatory and antidiabetic potential of Polygonum maritimum Google Scholar PT DOI
2017	Barreira L, Rešek E, Rodrigues MJoão, et al. Halophytes: Gourmet food with nutritional health benefits?. Journal of Food Composition and Analysis. 2017;59:35 - 42. doi:10.1016/j.jfca.2017.02.003 Read more about Halophytes: Gourmet food with nutritional health benefits? Google Scholar PT DOI
2016	Rodrigues MJoão, Neves V, Martins A, et al. In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Food Chem. 2016;200:322-9. doi:10.1016/j.foodchem.2016.01.048 Read more about In vitro antioxidant and anti-inflammatory properties of Limonium algarvense flowers' infusions and decoctions: A comparison with green tea (Camellia sinensis). Google Scholar PubMed DOI
2016	Pereira H, Custódio L, Rodrigues MJ, et al. Profiling of antioxidant potential and phytoconstituents of Plantago coronopus. Brazilian Journal of Biology. 2016;(ahead). doi:10.1590/1519-6984.02416 Read more about Profiling of antioxidant potential and phytoconstituents of Plantago coronopus Google Scholar DOI
2016	Lopes A, Rodrigues MJoão, Pereira C, et al. Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants. Industrial Crops and Products. 2016;94:299 - 307. doi:10.1016/j.indcrop.2016.08.040 Read more about Natural products from extreme marine environments: Searching for potential industrial uses within extremophile plants Google Scholar DOI
2016	Oliveira M, Junior PAdemar Sal, Rodrigues MJoão, et al. Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Asian Pac J Trop Med. 2016;9(8):735-41. doi:10.1016/j.apjtm.2016.06.015 Read more about Unlocking the in vitro anti-Trypanosoma cruzi activity of halophyte plants from the southern Portugal. Google Scholar PubMed DOI
2016	Ismael A, Henriques MSC, Marques C, et al. Exploring saccharinate-tetrazoles as selective Cu(. RSC Adv. 2016;6(75):71628 - 71637. doi:10.1039/C6RA15051A Read more about Exploring saccharinate-tetrazoles as selective Cu( Google Scholar DOI
2016	Custódio L, Laukaityte S, Engelen AH, et al. A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal. Natural Product Research. 2016;30(6):724 - 728. doi:10.1080/14786419.2015.1040791 Read more about A comparative evaluation of biological activities and bioactive compounds of the seagrasses Zostera marina and Zostera noltei from southern Portugal Google Scholar DOI
2015	Grosso C, Cardoso ALúcia, Lemos A, et al. Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Eur J Med Chem. 2015;93:9-15. doi:10.1016/j.ejmech.2015.01.050 Read more about Novel approach to bis(indolyl)methanes: de novo synthesis of 1-hydroxyiminomethyl derivatives with anti-cancer properties. Google Scholar PubMed DOI
2015	Pereira H, Custódio L, Rodrigues MJoão, et al. Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Mar Drugs. 2015;13(6):3531-49. doi:10.3390/md13063531 Read more about Biological Activities and Chemical Composition of Methanolic Extracts of Selected Autochthonous Microalgae Strains from the Red Sea. Google Scholar PubMed DOI
2014	Rodrigues MJoão, Gangadhar KN, Vizetto-Duarte C, et al. Maritime halophyte species from southern Portugal as sources of bioactive molecules. Mar Drugs. 2014;12(4):2228-44. doi:10.3390/md12042228 Read more about Maritime halophyte species from southern Portugal as sources of bioactive molecules. Google Scholar PubMed DOI

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