2023 |
Santos JMA, Laizé V, Gavaia PJ, Conceição N, M. Cancela L. Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies. International Journal of Molecular Sciences. 2023;24(4):3366. doi:10.3390/ijms24043366 |
2023 |
Adrião A, Mariano S, Mariano J, et al. mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour. Biomolecules. 2023;13(5):805. doi:10.3390/biom13050805 |
2023 |
Varela D, Varela T, Conceição N, M. Cancela L. Regulation of human ZNF687, a gene associated with Paget's disease of bone. The International Journal of Biochemistry & Cell Biology. 2023;154:106332. doi:10.1016/j.biocel.2022.106332 |
2022 |
Varela T, Varela D, Martins G, Conceição N, M. Cancela L. Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 2022;12(1). doi:10.1038/s41598-022-13364-1 |
2022 |
Adrião A, Santana I, Ribeiro C, M. Cancela L, Conceição N, Grazina M. Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration. Neurological Sciences. 2022;43(1):319 - 326. doi:10.1007/s10072-021-05269-0 |
2022 |
Silva IAL, Varela D, M. Cancela L, Conceição N. Zebrafish optineurin: genomic organization and transcription regulation. Genome. 2022;65(10):513 - 523. doi:10.1139/gen-2022-0019 |
2022 |
Simão M, Conceição N, Imaginário S, Amaro J, Cancela MLeonor. Lab-it is taking molecular genetics to school. BioChem. 2022;2(2):160 - 170. doi:10.3390/biochem2020011 |
2021 |
Varela D, Varela T, Conceição N, et al. Functional analysis of two novel TBX5 variants present in individuals with Holt–Oram syndrome with different clinical manifestations. Molecular Genetics and Genomics. 2021;296(4):809 - 821. doi:10.1007/s00438-021-01781-2 |
2021 |
Varela D, Conceição N, M. Cancela L. Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors. Gene. 2021;768:145322. doi:10.1016/j.gene.2020.145322 |
2021 |
Cancela ML, Laizé V, Conceição N, Kempf H, Murshed M. Keutel syndrome, a review of 50 years of literature. Frontiers in Cell and Developmental Biology. 2021;9:642136. doi:10.3389/fcell.2021.642136 |
2021 |
Varela T, Conceição N, Laizé V, Cancela ML. Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors. Journal of Cellular Biochemistry. 2021;122(10):1556 - 1566. doi:10.1002/jcb.v122.1010.1002/jcb.30078 |
2020 |
Caiado H, Conceição N, Tiago D, et al. Evaluation of MGP gene expression in colorectal cancer. Gene. 2020;723:144120. doi:10.1016/j.gene.2019.144120 |
2020 |
Caiado H, Conceição N, Tiago D, et al. Data on the evaluation of FGF2 gene expression in Colorectal Cancer. Data in Brief. 2020;31:105765. doi:10.1016/j.dib.2020.105765 |
2020 |
Varela T, Laizé V, Conceição N, et al. Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer. Biomarkers in Medicine. 2020;14(8):639 - 650. doi:10.2217/bmm-2019-0369 |
2019 |
Bäck M, Aranyi T, M. Cancela L, et al. Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet. Frontiers in Cardiovascular Medicine. 2019;5. doi:10.3389/fcvm.2018.00196 |
2018 |
Fazenda C, Martins G, Gavaia P, M. Cancela L, Conceição N. Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13662 |
2018 |
Silva IAL, Conceição N, Gagnon E, Brown JP, M. Cancela L, Michou L. Molecular effect of an OPTN common variant associated to Paget's disease of bone. PLOS ONE. 2018;13(5):e0197543. doi:10.1371/journal.pone.0197543.s007 |
2018 |
Vitorino M, Cunha N, Conceição N, M. Cancela L. Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome. Molecular Biology Reports. 2018. doi:10.1007/s11033-018-4180-1 |
2018 |
Vitorino M, Conceição N, M. Cancela L. Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome. Journal of Applied Ichthyology. 2018;34(2):489 - 500. doi:10.1111/jai.13667 |
2018 |
Silva IAL, Conceição N, Gagnon E, et al. Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018;1864(1):143 - 151. doi:10.1016/j.bbadis.2017.10.008 |
2016 |
Tiago DM, Conceição N, Caiado H, Laizé V, M. Cancela L. Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells. FEBS Letters. 2016;590(8):1234-1241. doi:10.1002/1873-3468.12155 |
2016 |
Adrião A, Conceição N, M. Cancela L. MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation. Arch Biochem Biophys. 2016;591:43-56. doi:10.1016/j.abb.2015.12.004 |
2016 |
Correia E, Conceição N, M. Cancela L, Belo JA. Matrix Gla Protein expression pattern in the early avian embryo. Int J Dev Biol. 2016;60(1-3):71-6. doi:10.1387/ijdb.150365jb |
2015 |
Fazenda C, Conceição N, M. Cancela L. Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene. Gene. 2015;572(1):57-62. doi:10.1016/j.gene.2015.06.079 |
2015 |
Silva IAL, Conceição N. Cloning, characterization and analysis of the 5′ regulatory region of zebrafish xpd gene. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2015;185:47 - 53. doi:10.1016/j.cbpb.2015.04.003 |
2015 |
Simões B, Conceição N, Matias AC, Bragança J, Kelsh RN, M. Cancela L. Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function. Arch Biochem Biophys. 2015;567:1-12. doi:10.1016/j.abb.2014.12.023 |
2014 |
M. Cancela L, Laizé V, Conceição N. Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization. Arch Biochem Biophys. 2014;561:56-63. doi:10.1016/j.abb.2014.07.020 |
2014 |
Simões B, Conceição N, Kelsh RN, M. Cancela L. Identification of cis -regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: implications for function. Journal of Applied Ichthyology. 2014;30(4):661 - 670. doi:10.1111/jai.2014.30.issue-410.1111/jai.12536 |
2014 |
Silva IAL, Conceição N, Michou L, M. Cancela L. Can zebrafish be a valid model to study Paget's disease of bone?. Journal of Applied Ichthyology. 2014;30(4):678 - 688. doi:10.1111/jai.2014.30.issue-410.1111/jai.12523 |
2014 |
Silva IAL, Cox CJ, Leite RB, M. Cancela L, Conceição N. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Comp Biochem Physiol B Biochem Mol Biol. 2014;172-173:9-20. doi:10.1016/j.cbpb.2014.03.007 |
2013 |
Conceição N, Viegas M, Fidalgo J, M. Cancela L. Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture. Mol Cell Biochem. 2013;373(1-2):41-51. doi:10.1007/s11010-012-1473-x |
2012 |
Fazenda C, Silva IAL, M. Cancela L, Conceição N. Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish. Journal of Applied Ichthyology. 2012;28(3):377 - 381. doi:10.1111/j.1439-0426.2012.02004.x |
2012 |
Michou L, Conceição N, Morissette J, et al. Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone. Bone. 2012;51(4):720-8. doi:10.1016/j.bone.2012.06.028 |
2012 |
M. Cancela L, Conceição N, Laizé V. Gla-rich protein, a new player in tissue calcification?. Adv Nutr. 2012;3(2):174-81. doi:10.3945/an.111.001685 |
2012 |
Silva IAL, M. Cancela L, Conceição N. Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). Mol Biol Rep. 2012;39(5):5339-48. doi:10.1007/s11033-011-1333-x |
2012 |
Conceição N, Fazenda C, M. Cancela L. Comparative gene promoter analysis: an in silico strategy to identify candidate regulatory factors for Gla Rich Protein. Journal of Applied Ichthyology. 2012;28(3):372 - 376. doi:10.1111/j.1439-0426.2012.02001.x |
2010 |
Fazenda C, Simões B, Kelsh RN, M. Cancela L, Conceição N. Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis. Gene. 2010;450(1-2):94-102. doi:10.1016/j.gene.2009.10.007 |
2010 |
Conceição N, Cox CJ, Simões B, Viegas M, M. Cancela L. Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes. Journal of Applied Ichthyology. 2010;26(2):245 - 250. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01415.x |
2008 |
Conceição N, Laizé V, Simões B, Pombinho AR, M. Cancela L. Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata. Biochim Biophys Acta. 2008;1779(1):28-39. doi:10.1016/j.bbagrm.2007.11.003 |
2006 |
Simões B, Conceição N, Viegas CSB, et al. Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Calcif Tissue Int. 2006;79(4):230-44. doi:10.1007/s00223-006-0111-6 |
2005 |
Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. J Bone Miner Res. 2005;20(8):1440-53. doi:10.1359/JBMR.050318 |
2005 |
Conceição N, Silva AC, Fidalgo J, Belo JA, M. Cancela L. Identification of alternative promoter usage for the matrix Gla protein gene. Evidence for differential expression during early development in Xenopus laevis. FEBS J. 2005;272(6):1501-10. doi:10.1111/j.1742-4658.2005.04590.x |
2003 |
Pinto JP, Conceição N, Gavaia P, M. Cancela L. Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata. Bone. 2003;32(3):201-10. |
2002 |
Conceição N, Henriques NM, Ohresser MCP, Hublitz P, Schüle R, M. Cancela L. Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity. Eur J Biochem. 2002;269(7):1947-56. |