CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN

Viegas, Carla; Santos, Lúcia; Macedo, Anjos; Morais, Rute; Silva, Ana; Neves, Pedro; Matos, António; Vermeer, Cees; Simes, Dina; Zubía, Eva; Simes, Dina

Dina Simes

Position

Senior Researcher

Academic Degree

Doutoramento

Group Leader

Functional Biochemistry and Proteomics

Group

Functional Biochemistry and Proteomics

Professor Category

Assistant

Institution

Universidade do Algarve, Faculdade de Ciencias e tecnologias

Based at

Faro, Gambelas Campus, UAlg

Office Nr

2.34, building 7

Phone Nr

+351 289800100

Extension

7216

dsimes@ualg.pt

ORCID ID

ResearchGate

Scopus

Organiza

Projects

Projects Coordination

	Title	Coordinator	Start	End	Financiamento	Budget CCMAR
	Application of Gla-rich Protein (GRP) in diagnostic and therapeutic of cardiovascular disease in Chronic Kidney Disease patients.	Carla Alexandra São Bento Viegas, Dina Simes	12/2022	12/2022	Sociedade Portuguesa de Nefrologia	15k€
Gla-rich protein novel markers	Gla-rich protein (GRP) associated to circulating calciprotein particles (CPP) and extracellular vesicles (EVs) as a novel marker of vascular calcification stress in diabetic with chronic kidney disease (CKD)	Carla Alexandra São Bento Viegas, Dina Simes	12/2019	12/2019	Sociedade Portuguesa de Nefrologia	15k€
OSTEOARTGRP	Nova abordagem para a identificação de alvos terapeuticos da osteoartrite: aplicação da proteomica 2D-DIGE.	Dina Simes	01/2011	06/2014	FCT - Fundação para a Ciência e Tecnologia	150k€
BIOMARKGRP	Estudos conducentes ao establecimento da GRP como biomarcador da calcificação vascular	Dina Simes	01/2010	07/2013	FCT - Fundação para a Ciência e Tecnologia	118k€
POCI 57921	Função na MGP na regulação local da mineralização da matriz extracelular- Identificação dos motivos estruturais responsáveis por essa função.	Dina Simes	09/2005	06/2008	FCT - Fundação para a Ciência e Tecnologia	86k€
Algae4IBD	ALGAE4IBD - From Nature to Bedsialgae based Bio Compound for Prevention and Treatment od Inflamation, Pain and IBD	Luísa Barreira, Dina Simes
	Characterization of bioengineered extracellular vesicles (EVs) loaded with Gla-rich protein: a proteomic approach	Carla Alexandra São Bento Viegas, Dina Simes			EPIC-XS

Projects Membership

	Title	Coordinator	Start	End	Budget CCMAR	Budget Total
FlameGRP	Exploring the therapeutic application of Gla-rich protein (GRP) in inflammation-related diseases using natural bioengineered nanovesicles	Carla Alexandra São Bento Viegas	12/2021	11/2023	49994k€
Gla-rich protein novel markers	Gla-rich protein (GRP) associated to circulating calciprotein particles (CPP) and extracellular vesicles (EVs) as a novel marker of vascular calcification stress in diabetic with chronic kidney disease (CKD)	Carla Alexandra São Bento Viegas, Dina Simes	12/2019	12/2019	15k€
SaMGP	Effect of extracellular calcium on MGP gene expression	Vincent Laizé	03/2003	03/2006	100k€	100k€
	Characterization of bioengineered extracellular vesicles (EVs) loaded with Gla-rich protein: a proteomic approach	Carla Alexandra São Bento Viegas, Dina Simes

Activities

Type of Event

Scientific Gathering

ProteoVilamoura 2022

This will be the 2 nd Joint Meeting of Spanish, French and Portuguese Proteomics Societies. The meeting was organized to include all aspects of proteomics and related fields focusing on new...

May 11, 2022 to May 13, 2022

News

Novo biomarcador ajuda a detetar doenças cardiovasculares em doentes renais

Um grupo de investigadores do Centro de Ciências do Mar (CCMAR), em parceria com o Centro Hospitalar Universitário do Algarve e em conjunto com a GenoGla Diagnostics, desenvolveu um novo teste diagnóstico utilizando um biomarcador de calcificação vascular presente no sangue. Este teste de uso fácil e resposta rápida será de grande utilidade no estudo da doença cardiovascular.

In the context of Science for Business, CCMAR received a delegation from Portugal Ventures on 7th of December, 2018.

In this event, the role of algae producing companies, new microalgae production strategies developed by LNEG, the concept of biorefinery of algal biomass and two round tables was presented.

“Cientificamente provável” is an outreach project that takes science into schools. This is the second year that the project is running with such a success that we can't accept much more applications.

Twelve young students from the high school participate in the internships that CCMAR offers in this year's edition, carried out by the CCVIVA - National Agency for Scientific Culture.

Our researchers are seeking collaborations for a Special Issue in the area of vitamin K and Vitamin K-Dependent proteins (VKDPs) in health and disease.

The Algae4IBD project, with CCMAR as a partner, aims to identify compounds from algae that are effective against inflammatory Bowel Disease and developing them into functional foods and new medication.

Citizens can now help our researchers identify these seaweeds, which can be invasive algae species with negative impacts

This event promoted the discussion of science and new ideas for projects between lectures, plenaries, talks, poster sessions and social events.

For the second year, researchers from CCMAR at the University of the Algarve are appealing to citizens to help them identify large accumulations of algae appearing in the ocean or on beaches along the Portuguese coast.

Publications

Year of Publication
2019	Viegas C, Edelweiss E, Schneider J, et al. Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP). Annals of Medicine. 2019;51(sup1):38 - 38. doi:10.1080/07853890.2018.1561804 Read more about Use of an innovative system and nanotechnology-based strategy for therapeutic applications of Gla-rich protein (GRP) Google Scholar DOI
2019	Araújo N, Viegas C, Perrolas I, et al. Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay. Annals of Medicine. 2019;51(sup1):43 - 43. doi:10.1080/07853890.2018.1561895 Read more about Amentadione is a new modulating agent for osteoarthritis in an ex-vivo co-culture preclinical assay Google Scholar DOI
2018	Silva APaula, Viegas C, Simes D, et al. GLA-RICH PROTEIN AS A NOVEL MARKER FOR CALCIFICATIONS IN DIABETIC PATIENTS WITH CKD. Nephrology Dialysis Transplantation. 2018;33(suppl_1):i493 - i493. doi:10.1093/ndt/gfy104.SP430 Read more about GLA-RICH PROTEIN AS A NOVEL MARKER FOR CALCIFICATIONS IN DIABETIC PATIENTS WITH CKD Google Scholar DOI
2017	Viegas C, Santos L, Macedo A, et al. CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN. Nephrology Dialysis Transplantation. 2017;32(suppl_3):iii67 - iii68. doi:10.1093/ndt/gfx123.MO055 Read more about CIRCULATING CALCIPROTEIN PARTICLES AND EXTRACELLULAR VESICLES AS NOVEL PLAYERS IN CHRONIC KIDNEY DISEASE VASCULAR CALCIFICATION. A ROLE FOR GLA-RICH PROTEIN Google Scholar DOI

Galleries

Dina Simes

Organiza

Projects Coordination

Projects Membership

Novo biomarcador ajuda a detetar doenças cardiovasculares em doentes renais

CCMAR in the meeting with Portugal Ventures

Workshop Algae was a success

CCMAR project brings science to schools

Summer internships entice young people to science

Calling all experts in vitamin K-dependent Proteins!

New research with algae brings hope for inflammatory bowel diseases

New platform will monitor the accumulation of seaweeds on beaches

ProteoVilamoura gathered more than 150 participants!

Platform "Algas na Praia" will monitor again algae accumulations in the Portuguese coast