Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization

Braz, Luis; Ana Grenha; Ferreira, Domingos; Rosa da Costa, Ana M.; Gamazo, Carlos; Sarmento, Bruno

Ana Grenha

Posição

Senior Researcher

Grau Académico

Doutoramento

Cargo

Membro da Direção

Grupo

Marine Molecular Bioengineering

Categoria

Assistant

Instituição

University of Algarve, Faculty of Sciences and Technology

Localização

Faro, Gambelas Campus, UAlg

Gabinete

3.1, Bld 8

Contacto

+351 289800100

Extensão

7441

amgrenha@ualg.pt

Keywords

Drug delivery, Encapsulation processes, Nanoparticles, Microparticles, Polysaccharide-based carriers

ORCID ID

Organiza

Projetos

Projects Membership

	Título	Coordenador	Início	Fim	Orçamento	Orçamento Total
GERMROS	The imprinting characteristics of spermatogonia antioxidant capacity and their role in oxidative stress tolerance	Elvira Fernandez	01/2022	07/2023

Eventos

Tipo de Evento

Outros Eventos

Defesa da tese de doutoramento da Ludmylla Cunha

Esta sexta-feira, 1 de Fevereiro, será um dia especial para a estudante de doutoramento Ludmylla Cunha: vai defender a sua tese de doutoramento, que teve a orientação da investigadora Ana Grenha...

Sex, 01/02/2019

Local

Anfiteatro Verde, Building 8, Gambelas Campus

Tipo de Evento

Outros Eventos

Apresentação da tese de doutoramento de Susana Rodrigues

Esta sexta-feira, a nossa doutoranda Susana Rodrigues, irá apresentar e defender a sua tese na Universidade do Algarve às 14:30h.

Grupo

Marine Molecular Bioengineering

Sex, 20/12/2019

Local

Anfiteatro Teresa Gamito | Building 1 | Gambelas Campus

Notícias

News

CCMAR marca presença no 4º Congresso Internacional de Áreas Marinhas Protegidas (IMPAC4)

O CCMAR marcou presença no 4º Congresso Internacional de Áreas Marinhas Protegidas (IMPAC4), que ocorreu no Chile de 4 a 8 de Setembro de 2017.

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Três investigadoras do CCMAR receberam prémios Tech2Market

Ana Grenha receives her Tech2Market honorable mention (photo credits: UAlg Communication Department)

Ana Grenha, Maria Clara Costa e Luísa Custódio receberam menções honrosas no concurso Tech2Market promovido pela Universidade do Algarve. Fomos falar com as investigadoras para saber mais sobre as suas tecnologias e futuras prospectivas.

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Projeto inovador do CCMAR sobre vacinação ganha Prémio Robalo Cordeiro SPP/AstraZeneca/Novartis 2020

A nossa investigadora Ana Grenha ganhou o Prémio SPP Robalo Cordeiro 2020 atribuído ao seu novo projeto “Imunização por via inalatória – Uma estratégia para as doenças respiratórias”.

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Investigadores do CCMAR ganham prémio Melhor Comunicação Oral no 36º Congresso de Pneumologia

A equipa ganhou o prémio (ex-aequo) com o trabalho “Terapêutica inalável da tuberculose: um alinhamento da via de administração do fármaco com a via de infeção”, partilhado com outro projeto.

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Ana Grenha vence primeira edição do Prémio Investigador UAlg 2022

Este foi o primeiro ano que a Universidade do Algarve atribuiu este prémio no valor de 5 mil euros.

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Publicações

Publicações Selecionadas

Braz L, Grenha A, Ferreira D, da Costa AMRosa, Gamazo C, Sarmento B. Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization. International Journal of Biological Macromolecules. 2017;96:786 - 797. doi:10.1016/j.ijbiomac.2016.12.076

Publicações

Year of Publication
2017	Braz L, Grenha A, Ferreira D, da Costa AMRosa, Gamazo C, Sarmento B. Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization. International Journal of Biological Macromolecules. 2017;96:786 - 797. doi:10.1016/j.ijbiomac.2016.12.076 Ler mais acerca de Chitosan/sulfated locust bean gum nanoparticles: In vitro and in vivo evaluation towards an application in oral immunization Google Scholar DOI
2016	Alves AD, Cavaco JS, Guerreiro F, Lourenço JP, da Costa AMRosa, Grenha A. Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles. Molecules. 2016;21(6). doi:10.3390/molecules21060702 Ler mais acerca de Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles. Google Scholar PubMed DOI
2016	Cunha L, Grenha A. Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications. Marine Drugs. 2016;14(3):42. doi:10.3390/md14030042 Ler mais acerca de Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications Google Scholar DOI
2016	Dionísio M, Braz L, Corvo M, Lourenço JP, Grenha A, da Costa AMRosa. Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation. International Journal of Biological Macromolecules. 2016;86:129 - 138. doi:10.1016/j.ijbiomac.2016.01.054 Ler mais acerca de Charged pullulan derivatives for the development of nanocarriers by polyelectrolyte complexation Google Scholar DOI
2015	Rodrigues S, Cordeiro C, Seijo B, Remuñán-López C, Grenha A. Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation. Carbohydrate Polymers. 2015;123:369 - 380. doi:10.1016/j.carbpol.2015.01.048 Ler mais acerca de Hybrid nanosystems based on natural polymers as protein carriers for respiratory delivery: Stability and toxicological evaluation Google Scholar DOI
2015	Rodrigues S, Grenha A. Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy. Current Pharmaceutical Design. 2015;21(33):4869 - 4887. doi:10.2174/1381612821666150820103910 Ler mais acerca de Activation of Macrophages: Establishing a Role for Polysaccharides in Drug Delivery Strategies Envisaging Antibacterial Therapy Google Scholar DOI
2015	Rodrigues S, Cardoso L, da Costa A, Grenha A. Biocompatibility and Stability of Polysaccharide Polyelectrolyte Complexes Aimed at Respiratory Delivery. Materials. 2015;8(9):5647 - 5670. doi:10.3390/ma8095268 Ler mais acerca de Biocompatibility and Stability of Polysaccharide Polyelectrolyte Complexes Aimed at Respiratory Delivery Google Scholar DOI
2015	Grenha A. Editorial (Thematic Issue: Exploring the Role of Polysaccharides in Drug Delivery). Current Pharmaceutical Design. 2015;21(33):4773 - 4774. doi:10.2174/1381612821999150903143853 Ler mais acerca de Editorial (Thematic Issue: Exploring the Role of Polysaccharides in Drug Delivery) Google Scholar DOI
2015	Santos MA dos, Grenha A. Advances In Protein Chemistry And Structural Biologyprotein And Peptide Nanoparticles For Drug Deliverypolysaccharide Nanoparticles For Protein And Peptide Delivery. Vol. 98. Elsevier; 2015:223 - 261. doi:10.1016/bs.apcsb.2014.11.003 Ler mais acerca de Advances in Protein Chemistry and Structural BiologyProtein and Peptide Nanoparticles for Drug DeliveryPolysaccharide Nanoparticles for Protein and Peptide Delivery Google Scholar DOI
2014	Perestrelo ARubina, Grenha A, da Costa AMRosa, Belo JAntónio. Locust bean gum as an alternative polymeric coating for embryonic stem cell culture. Materials Science and Engineering: C. 2014;40:336 - 344. doi:10.1016/j.msec.2014.04.022 Ler mais acerca de Locust bean gum as an alternative polymeric coating for embryonic stem cell culture Google Scholar DOI
2014	Nunes R, Rodrigues S, Pasko P, Tyszka-Czochara M, Grenha A, de Carvalho ISaraiva. Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection. Industrial Crops and Products. 2014;52:99 - 104. doi:10.1016/j.indcrop.2013.10.015 Ler mais acerca de Effect of Erica australis extract on Caco-2 cells, fibroblasts and selected pathogenic bacteria responsible for wound infection Google Scholar DOI
2013	Grenha A, Rodrigues S. Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery. Therapeutic Delivery. 2013;4(11):1339 - 1341. doi:10.4155/tde.13.99 Ler mais acerca de Pullulan-based nanoparticles: future therapeutic applications in transmucosal protein delivery Google Scholar DOI
2013	Dionísio M, Cordeiro C, Remuñán-López C, Seijo B, da Costa AMRosa, Grenha A. Pullulan-based nanoparticles as carriers for transmucosal protein delivery. European Journal of Pharmaceutical Sciences. 2013;50(1):102 - 113. doi:10.1016/j.ejps.2013.04.018 Ler mais acerca de Pullulan-based nanoparticles as carriers for transmucosal protein delivery Google Scholar DOI
2013	Costa H, Grenha A. Natural carriers for application in tuberculosis treatment. Journal of Microencapsulation. 2013;30(3):295 - 306. doi:10.3109/02652048.2012.726283 Ler mais acerca de Natural carriers for application in tuberculosis treatment Google Scholar DOI
2012	Rodrigues S, Dionísio M, López CRemuñán, Grenha A. Biocompatibility of Chitosan Carriers with Application in Drug Delivery. Journal of Functional Biomaterials. 2012;3(4):615 - 641. doi:10.3390/jfb3030615 Ler mais acerca de Biocompatibility of Chitosan Carriers with Application in Drug Delivery Google Scholar DOI
2012	Grenha A, Dionísio M. Locust bean gum: Exploring its potential for biopharmaceutical applications. Journal of Pharmacy and Bioallied Sciences. 2012;4(3):175. doi:10.4103/0975-7406.99013 Ler mais acerca de Locust bean gum: Exploring its potential for biopharmaceutical applications Google Scholar DOI
2012	Rodrigues S, da Costa AMRosa, Grenha A. Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios. Carbohydrate Polymers. 2012;89(1):282 - 289. doi:10.1016/j.carbpol.2012.03.010 Ler mais acerca de Chitosan/carrageenan nanoparticles: Effect of cross-linking with tripolyphosphate and charge ratios Google Scholar DOI
2012	Grenha A. Chitosan nanoparticles: a survey of preparation methods. Journal of Drug Targeting. 2012;20(4):291 - 300. doi:10.3109/1061186X.2011.654121 Ler mais acerca de Chitosan nanoparticles: a survey of preparation methods Google Scholar DOI
2012	Al-Qadi S, Grenha A, Carrión-Recio D, Seijo B, Remuñán-López C. Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations. Journal of Controlled Release. 2012;157(3):383 - 390. doi:10.1016/j.jconrel.2011.08.008 Ler mais acerca de Microencapsulated chitosan nanoparticles for pulmonary protein delivery: In vivo evaluation of insulin-loaded formulations Google Scholar DOI

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