Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation

Poudel, Sunil; Martins, Gil; Cancela, M. Leonor; Gavaia, Paulo J.; Santos, Tamára; Martins, Gil; de Castro, Daniela T.; Silva, Nadia; Cabrita, Elsa; Bebianno, Maria J.; Stainier, Didier Y.R.; Cancela, M. Leonor; Laizé, Vincent; Conceição, L. E. C.

Paulo Jorge Travessa Gavaia

Position

Senior Researcher

Academic Degree

Doutoramento

Group Leader

Comparative, Adaptive and Functional Skeletal Biology

Group

Comparative, Adaptive and Functional Skeletal Biology

Professor Category

Assistant

Institution

Universidade do Algarve

Based at

Faro, Gambelas Campus, UAlg

Office Nr

2.76

Phone Nr

+351 289800057

Extension

7057

pgavaia@ualg.pt

Keywords

bone development, zebrafish; extracellular matrix mineralization, Aquaculture, gene regulation, gene expression, fish models of human diseases

Organiza

Main Info

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Projects

Projects Coordination

	Title	Coordinator	Start	End	Financiamento	Budget CCMAR	Budget Total
SPECIAL_K	Efeitos da suplementação nutricional em vitamina K no crescimento e desenvolvimento esquelético de peixes teleósteos	Paulo Jorge Travessa Gavaia	02/2010	07/2013	FCT - Fundação para a Ciência e Tecnologia	195k€	195107k€
XENOFISH II	Efeito de compostos xenobióticos no desenvolvimento do esqueleto e regeneração de barbatana de peixe.	Paulo Jorge Travessa Gavaia	01/2007	12/2008	FCT - Fundação para a Ciência e Tecnologia	30k€
XENOFISH	Efeito de compostos xenobióticos no desenvolvimento do esqueleto e regeneração de barbatana de peixe.	Paulo Jorge Travessa Gavaia	01/2006	12/2008	FCT - Fundação para a Ciência e Tecnologia	50k€

Projects Membership

	Title	Coordinator	Start	End	Budget CCMAR	Budget Total
DEEPBONE	DEEPBONE - Biologia do osso de peixes de profundidade	Vincent Laizé	01/2012	06/2015	109k€	109k€
AQUATOX	Avaliação da toxidade óssea de poluentes aquáticos.	Vincent Laizé	07/2011	12/2014	113k€	113k€
EPISOLE	Regulação epigenética do desenvolvimento e crescimento em linguado Senegalês (Solea senegalensis)	Sofia Engrola	02/2011	08/2014	87k€
ULTRAFISH	ULTRAFISH - Utilização de ultrasons na optimização da nutrição embrionária de peixes: programação nutricional do potencial de crescimento e capacidades metabólicas em juvenis.	Jorge Dias	03/2010	08/2013	190k€

Activities

Type of Event

Other Events

Get together CCMAR / Farewell party

Join us to a farewell party with the students from Summer School Shou (China). We're waiting for you!

July 29, 2016

Building 7 - main hall

Type of Event

Other Events

Get together CCMAR / Welcome party

Next week, join us to welcome the students from Summer School Shou (China). We're waiting for you!

July 11, 2016

Building 7 - main hall

Type of Event

Scientific Gathering

UTILIZAÇÃO DO PEIXE ZEBRA COMO MODELO EM BIOMEDICINA E ESTUDO DE PATOLOGIAS HUMANAS

Fornecer conhecimentos básicos sobre a utilização do modelo biológico peixe-zebra com principal incidência na sua utilização no âmbito do estudo de patologias humanas e nas ciências biomédicas...

April 13, 2016

CCMAR

Type of Event

Other Events

Semana da Cultura Científica do CCMAR 2016

Data: 21 a 25 de Novembro de 2016 PROGRAMA COMPLETO

November 21, 2016 to November 25, 2016

CCMAR - Universidade do Algarve - Campus de Gambelas (Faro)

Type of Event

Scientific Gathering

IAFSB 2015: 4th Conference “Interdisciplinary Approaches in Fish Skeletal Biology”

Group

Comparative, Adaptive and Functional Skeletal Biology

April 27, 2015 to April 30, 2015

Tavira, Algarve, Portugal

Palestra: Zebrafish and medaka as models to study skeletal development in aquaculture and biomedical research

7 de Julho 13:30 horas Anfiteatro C (Complexo pedagógico - Campus Gambelas da UAlg)

Type of Event

Seminar

CCMAR Seminars by Izasa Scientific: Vitamin K in Fish Skeletal Biology

CCMAR SEMINARS 8th FEB | 13:30 | Anf. 1.8 (Edf. 8) Vitamin K in Fish Skeletal Biology Paulo Gavaia (CCMAR - BIOSKEL) Poster Abstract Vitamin K (VK) is a fat soluble vitamin discovered by Henrik Dam...

Group

Comparative, Adaptive and Functional Skeletal Biology

February 8, 2017

Anf. 1.8 (edf. 8) - Gambelas Campus UAlg

ATT: Using Zebrafish as a model in Biomedicine and study of human diseases - 3rd Edition

21st April 2017 Organization: CCMAR Location: Universidade do Algarve - Campus de Gambelas (limited places)

Group

Comparative, Adaptive and Functional Skeletal Biology

April 21, 2017

CCMAR - Universidade do Algarve - Campus de Gambelas (Faro)

Type of Event

Other Events

Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB) 2018

The fifth conference “Interdisciplinary Approaches in Fish Skeletal Biology” takes place in Tavira, Portugal, April 16-19, 2018.

April 16, 2018 to April 19, 2018

Faro

Type of Event

Scientific Gathering

IAFSB 2009: 1st meeting "Interdisciplinary Approaches in Fish Skeletal Biology"

Group

Comparative, Adaptive and Functional Skeletal Biology

April 27, 2009 to April 29, 2009

Tavira, Algarve, Portugal

Using zebrafish as a model in biomedicine and the study of human diseases. 2nd edition

This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences...

Group

Comparative, Adaptive and Functional Skeletal Biology

May 12, 2016

Type of Event

Scientific Gathering

IAFSB 2011: 2nd Conference “Interdisciplinary Approaches in Fish Skeletal Biology”

Group

Comparative, Adaptive and Functional Skeletal Biology

April 26, 2011 to April 28, 2011

Tavira, Algarve, Portugal

Type of Event

Other Events

LARVITA 2012 Training School: Biological basis for improving fish larvae quality

The goal of LARVITA 2012 Training School is to highlight the most recent developments in Biological basis for improving fish larvae quality and to promote a strong interaction between proactive...

Group

Aquaculture Research Group

December 5, 2012 to December 7, 2012

Type of Event

Scientific Gathering

IAFSB 2013: 3rd meeting “Interdisciplinary Approaches in Fish Skeletal Biology”

Group

Comparative, Adaptive and Functional Skeletal Biology

April 22, 2013 to April 24, 2013

Tavira, Algarve, Portugal

Type of Event

Other Events

PhD Thesis Presentation of Patrícia Diogo

This Friday, our PhD candidate Patrícia Diogo will defend her thesis about cryopreservation of zebrafish germ cells.

Group

Comparative, Adaptive and Functional Skeletal Biology

October 18, 2019

Anfiteatro Verde, Edf 8

News

Experts discuss the skeleton during this week

CCMAR organizes this week the fifth conference “Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB)” in Tavira, Portugal.

programa da Radio Antena 1

Investigadores da UALG estão a estudar moléculas para ser usadas na regeneração óssea (90 Segundos de Ciência 2018-10-17)

Between the 6^th and 18^th of December 9 students of the Master in Marine Biology will defend their thesis.

Last February, CCMAR participated in the open day of the University of Algarve and received about 120 students.

Twelve young students from the high school participate in the internships that CCMAR offers in this year's edition, carried out by the CCVIVA - National Agency for Scientific Culture.

Our researcher Paulo Gavaia will present an oral presentation entitled: “Using zebrafish as a tool in bioprospection for osteogenic molecules”.

Our researchers had a strong presence at the annual conference of the European Aquaculture Society, where they won the best poster award among more than 800 submitted works and made several oral presentations.

Publications

Selected Publications

Laizé V, Gavaia P, M. Cancela L. Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. 2014;13:29-37. doi:10.1016/j.ddmod.2014.08.001

Richard N, Fernández I, Wulff T, et al. Dietary supplementation with vitamin k affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Mar Biotechnol (NY). 2014;16(5):522-37. doi:10.1007/s10126-014-9571-2

Cardeira J, Gavaia P, Fernández I, et al. Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin. Scientific Reports. 2016;6:39191. doi:10.1038/srep39191

Tarasco M, Laizé V, Cardeira J, M. Cancela L, Gavaia P. The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;197:45 - 52. doi:10.1016/j.cbpc.2017.04.006

Roberto VP, Gavaia P, Nunes MJ, Rodrigues E, M. Cancela L, Tiago DM. Evidences for a New Role of miR-214 in Chondrogenesis. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-21735-w

Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. Effects of pristine or contaminated polyethylene microplastics on zebrafish development. Chemosphere. 2022;303:135198. doi:10.1016/j.chemosphere.2022.135198

Poudel S, Martins G, M. Cancela L, Gavaia PJ. Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation. International Journal of Molecular Sciences. 2022;23(23):15160. doi:10.3390/ijms232315160

Publications

Year of Publication
2023	Santos JMA, Laizé V, Gavaia PJ, Conceição N, M. Cancela L. Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies. International Journal of Molecular Sciences. 2023;24(4):3366. doi:10.3390/ijms24043366 Read more about Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies Google Scholar PT DOI
2023	Soares F, Costas B, Lourenço-Marques C, Fernández I, Gavaia P. Climate Change On Diseases And Disorders Of Finfish In Cage Culture. Chapter 7- Non-Infectious Disorders Of Warmwater Fish. 3rd ed. (Woo PTK, Subasinghe RP, eds.). GB: CABI; 2023:278 - 314. doi:10.1079/9781800621640.0007 Read more about Climate Change on Diseases and Disorders of Finfish in Cage Culture. Chapter 7- Non-Infectious Disorders of Warmwater Fish Google Scholar PT DOI
2023	Berntssen MHG, Fjeldal PG, Gavaia PJ, et al. Dietary beauvericin and enniatin B exposure cause different adverse health effects in farmed Atlantic salmon. Food and Chemical Toxicology. 2023;174:113648. doi:10.1016/j.fct.2023.113648 Read more about Dietary beauvericin and enniatin B exposure cause different adverse health effects in farmed Atlantic salmon Google Scholar PT DOI
2023	Dellacqua Z, Di Biagio C, Costa C, et al. Distinguishing the Effects of Water Volumes versus Stocking Densities on the Skeletal Quality during the Pre-Ongrowing Phase of Gilthead Seabream (Sparus aurata). Animals. 2023;13(4):557. doi:10.3390/ani13040557 Read more about Distinguishing the Effects of Water Volumes versus Stocking Densities on the Skeletal Quality during the Pre-Ongrowing Phase of Gilthead Seabream (Sparus aurata) Google Scholar PT DOI
2023	Diogo P, Martins G, Simão M, et al. Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts. International Journal of Molecular Sciences. 2023;24(8):7035. doi:10.3390/ijms24087035 Read more about Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts Google Scholar PT DOI
2023	Adrião A, Mariano S, Mariano J, et al. mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour. Biomolecules. 2023;13(5):805. doi:10.3390/biom13050805 Read more about mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour Google Scholar PT DOI
2023	Carletti A, Rosa JT, Pes K, et al. The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and Molecular Life Sciences. 2023;80(10). doi:10.1007/s00018-023-04953-y Read more about The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models Google Scholar PT DOI
2023	Fernandes JMO, Nedoluzhko AV, Konstantinidis I, Gavaia P. Epigenetics In Fish Growth Chpt. 9. 1st ed. (Piferrer F, Wang H‐P, eds.). Wiley; 2023:209 - 230. doi:10.1002/978111982194610.1002/9781119821946.ch9 Read more about Epigenetics in Fish Growth Chpt. 9 Google Scholar PT DOI
2022	Rosa JT, Tarasco M, Gavaia PJ, M. Cancela L, Laizé V. Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy. Pharmaceuticals. 2022;15(8):983. doi:10.3390/ph15080983 Read more about Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy Google Scholar PT DOI
2022	Carletti A, Cardoso C, Lobo-Arteaga J, et al. Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae. Frontiers in Nutrition. 2022;9. doi:10.3389/fnut.2022.888360 Read more about Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae Google Scholar PT DOI
2022	Poudel S, Martins G, M. Cancela L, Gavaia PJ. Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation. International Journal of Molecular Sciences. 2022;23(23):15160. doi:10.3390/ijms232315160 Read more about Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation Google Scholar PT DOI
2022	Acosta M, Quiroz E, Tovar-Ramírez D, et al. Fish Microbiome Modulation and Convenient Storage of Aquafeeds When Supplemented with Vitamin K1. Animals. 2022;12(23):3248. doi:10.3390/ani12233248 Read more about Fish Microbiome Modulation and Convenient Storage of Aquafeeds When Supplemented with Vitamin K1 Google Scholar PT DOI
2022	Cardeira-da-Silva J, Bensimon-Brito A, Tarasco M, et al. Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish. Proceedings of the National Academy of Sciences. 2022;119(48). doi:10.1073/pnas.2209231119 Read more about Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish Google Scholar PT DOI
2022	Poudel S, Martins G, M. Cancela L, Gavaia PJ. Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish. Nutrients. 2022;14(23):4959. doi:10.3390/nu14234959 Read more about Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish Google Scholar PT DOI
2022	Poudel S, Martins G, Cancela LM, Gavaia P. Resveratrol-mediated reversal of Doxorubicin-induced osteoclast differentiation alleviates oxidative stress via FoxM1 expression. Bone Reports. 2022;16:101396. doi:10.1016/j.bonr.2022.101396 Read more about Resveratrol-mediated reversal of Doxorubicin-induced osteoclast differentiation alleviates oxidative stress via FoxM1 expression Google Scholar PT DOI
2022	Poudel S, Izquierdo M, Cancela MLeonor, Gavaia PJ. Reversal of Doxorubicin-Induced Bone Loss and Mineralization by Supplementation of Resveratrol and MitoTEMPO in the Early Development of Sparus aurata. Nutrients. 2022;14(6):1154. doi:10.3390/nu14061154 Read more about Reversal of Doxorubicin-Induced Bone Loss and Mineralization by Supplementation of Resveratrol and MitoTEMPO in the Early Development of Sparus aurata Google Scholar PT DOI
2022	Sojan JMaria, Gundappa MKumar, Carletti A, et al. Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in Nutrition. 2022;9. doi:10.3389/fnut.2022.868805 Read more about Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism Google Scholar PT DOI
2022	Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. Effects of pristine or contaminated polyethylene microplastics on zebrafish development. Chemosphere. 2022;303:135198. doi:10.1016/j.chemosphere.2022.135198 Read more about Effects of pristine or contaminated polyethylene microplastics on zebrafish development Google Scholar PT DOI
2021	Rosa JT, Laizé V, Gavaia PJ, Cancela ML. Fish models of induced osteoporosis. Frontiers in Cell and Developmental Biology. 2021;9:672424. doi:10.3389/fcell.2021.672424 Read more about Fish models of induced osteoporosis Google Scholar PT DOI
2021	Kumar N, Carletti A, Gavaia PJ, et al. Lecture Notes In Computer Science- Computer Analysis Of Images And Patterns: Deep Learning Approaches For Head And Operculum Segmentation In Zebrafish Microscopy Images. Vol. 13052. (Tsapatsoulis N, Panayides A, Theocharides T, Lanitis A, Pattichis C, Vento M, eds.). Cham: Springer International Publishing; 2021:154 - 164. doi:10.1007/978-3-030-89128-2_15 Read more about Lecture Notes in Computer Science- Computer Analysis of Images and Patterns: Deep Learning Approaches for Head and Operculum Segmentation in Zebrafish Microscopy Images Google Scholar PT DOI
2021	Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. New insights into benzo[⍺]pyrene osteotoxicity in zebrafish. Ecotoxicology and Environmental Safety. 2021;226:112838. doi:10.1016/j.ecoenv.2021.112838 Read more about New insights into benzo[⍺]pyrene osteotoxicity in zebrafish Google Scholar PT DOI
2021	Rosa J, Carletti A, Varela T, Gavaia PJ, M. Cancela L, Laizé V. Identification of bone anabolic compounds of marine origin using a zebrafish pipeline. Bone Reports. 2021;14:100985. doi:10.1016/j.bonr.2021.100985 Read more about Identification of bone anabolic compounds of marine origin using a zebrafish pipeline Google Scholar PT DOI
2021	Poudel S, Izquierdo M, M. Cancela L, Gavaia PJ. Reversal of Doxorubicin-induced bone loss by antioxidant supplement. Bone Reports. 2021;14:100984. doi:10.1016/j.bonr.2021.100984 Read more about Reversal of Doxorubicin-induced bone loss by antioxidant supplement Google Scholar PT DOI
2020	Tarasco M, Martins G, Gavaia PJ, Bebianno MJ, M. Cancela L, Laizé V. ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts. Zebrafish. 2020;17(1):18-26. doi:10.1089/zeb.2019.1801 Read more about ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts Google Scholar PT DOI
2020	Martins G, Diogo P, Santos T, et al. Microdiet Formulation with Phospholipid Modulate Zebrafish Skeletal Development and Reproduction. Zebrafish. 2020. doi:10.1089/zeb.2019.1794 Read more about Microdiet Formulation with Phospholipid Modulate Zebrafish Skeletal Development and Reproduction Google Scholar DOI
2020	Viegas MN, Salgado MAntonia, Aguiar C, Almeida A, Gavaia P, Dias J. Effect of Dietary Manganese and Zinc Levels on Growth and Bone Status of Senegalese Sole (Solea senegalensis) Post-Larvae. Biological Trace Element Research. 2020. doi:10.1007/s12011-020-02307-4 Read more about Effect of Dietary Manganese and Zinc Levels on Growth and Bone Status of Senegalese Sole (Solea senegalensis) Post-Larvae Google Scholar PT DOI
2020	Beato S, Marques C, Laizé V, Gavaia PJ, Fernández I. New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data. International Journal of Molecular Sciences. 2020;21(10):3489. doi:10.3390/ijms21103489 Read more about New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data Google Scholar PT DOI
2020	Vijayakumar P, Cardeira J, Laizé V, Gavaia PJ, M. Cancela L. Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages. Marine Biotechnology. 2020;22(3):333 - 347. doi:10.1007/s10126-019-09937-3 Read more about Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages Google Scholar PT DOI
2020	Carletti A, Cardoso C, Juliao D, et al. Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses. Proceedings. 2020;61(1):13. doi:10.3390/IECN2020-06994 Read more about Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses Google Scholar PT DOI
2019	Granadeiro L, Dirks RP, Ortiz-Delgado JB, et al. Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns. Ecotoxicology and Environmental Safety. 2019;181:559 - 571. doi:10.1016/j.ecoenv.2019.06.042 Read more about Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns Google Scholar PT DOI
2019	Simão M, Gavaia PJ, Camacho A, et al. Intracellular iron uptake is favored in Hfe ‐KO mouse primary chondrocytes mimicking an osteoarthritis‐related phenotype. BioFactors. 2019. doi:10.1002/biof.1520 Read more about Intracellular iron uptake is favored in Hfe ‐KO mouse primary chondrocytes mimicking an osteoarthritis‐related phenotype Google Scholar PT DOI
2019	Diogo P, Martins G, Nogueira R, Marreiros A, Gavaia PJ, Cabrita E. Cryoprotectants synergy improve zebrafish sperm cryopreservation and offspring skeletogenesis. Cryobiology. 2019. doi:10.1016/j.cryobiol.2019.10.001 Read more about Cryoprotectants synergy improve zebrafish sperm cryopreservation and offspring skeletogenesis Google Scholar DOI
2019	Fernández I, Fernandes JMO, Roberto VP, et al. Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish. Biochimica et Biophysica Acta (BBA) - General Subjects. 2019;1863(1):39-51. doi:10.1016/j.bbagen.2018.09.017 Read more about Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish Google Scholar DOI
2019	Carvalho FR, Calado SM, Silva GA, et al. Altered bone microarchitecture in a type 1 diabetes mouse model Ins2 ^Akita. Journal of Cellular Physiology. 2019;234(6):9338-9350 . doi:10.1002/jcp.27617 Read more about Altered bone microarchitecture in a type 1 diabetes mouse model Ins2 Akita Google Scholar DOI
2019	Navarro-Guillén C, Dias J, Rocha F, et al. Does a ghrelin stimulus during zebrafish embryonic stage modulate its performance on the long-term?. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2019;228:1 - 8. doi:10.1016/j.cbpa.2018.10.019 Read more about Does a ghrelin stimulus during zebrafish embryonic stage modulate its performance on the long-term? Google Scholar DOI
2019	Diogo P, Martins G, Eufrásio A, Silva T, Cabrita E, Gavaia P. Selection Criteria of Zebrafish Male Donors for Sperm Cryopreservation. Zebrafish. 2019;16(2):189-196. doi:10.1089/zeb.2018.1660 Read more about Selection Criteria of Zebrafish Male Donors for Sperm Cryopreservation Google Scholar DOI
2019	Martins G, Diogo P, Pinto W, Gavaia PJ. Early Transition to Microdiets Improves Growth, Reproductive Performance and Reduces Skeletal Anomalies in Zebrafish ( Danio rerio ). Zebrafish. 2019;16(3):300-307. doi:10.1089/zeb.2018.1691 Read more about Early Transition to Microdiets Improves Growth, Reproductive Performance and Reduces Skeletal Anomalies in Zebrafish ( Danio rerio ) Google Scholar DOI
2019	Carson MA, Nelson J, M. Cancela L, et al. Correction: Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. PLOS ONE. 2019;14(1):e0211395. doi:10.1371/journal.pone.0211395 Read more about Correction: Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum Google Scholar DOI
2019	Tarasco M, Cardeira J, Viegas M, et al. Anti-osteogenic activity of cadmium in zebrafish. Fishes. 2019;4(1):11. doi:10.3390/fishes4010011 Read more about Anti-osteogenic activity of cadmium in zebrafish Google Scholar DOI
2019	Santos JMA, Mendes-Silva L, Afonso V, et al. Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants. Cell Death & Disease. 2019;10(8). doi:10.1038/s41419-019-1816-6 Read more about Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants Google Scholar PT DOI
2019	Martins G, Ribeiro L, Candeias‐Mendes A, et al. Reduction of skeletal anomalies in meagre ( Argyrosomus regius , Asso, 1801) through early introduction of inert diet. Aquaculture Research. 2019;50(10):2782 - 2792. doi:10.1111/are.v50.1010.1111/are.14230 Read more about Reduction of skeletal anomalies in meagre ( Argyrosomus regius , Asso, 1801) through early introduction of inert diet Google Scholar DOI
2018	Fazenda C, Martins G, Gavaia P, M. Cancela L, Conceição N. Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13662 Read more about Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein Google Scholar DOI
2018	Cardeira J, Laizé V, Martins G, M. Cancela L, Gavaia P. An overview on the teleost bone mechanophysiology. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13661 Read more about An overview on the teleost bone mechanophysiology Google Scholar DOI
2018	Diogo P, Martins G, Quinzico I, Nogueira R, Gavaia P, Cabrita E. Electric ultrafreezer (− 150 °C) as an alternative for zebrafish sperm cryopreservation and storage. Fish Physiology and Biochemistry. 2018. doi:10.1007/s10695-018-0500-6 Read more about Electric ultrafreezer (− 150 °C) as an alternative for zebrafish sperm cryopreservation and storage Google Scholar DOI
2018	Carson MA, Nelson J, M. Cancela L, et al. Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-26024-0 Read more about Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae Google Scholar DOI
2018	Laizé V, Gavaia P, Tarasco M, et al. Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and Environmental Safety. 2018;161:721 - 728. doi:10.1016/j.ecoenv.2018.06.035 Read more about Osteotoxicity of 3-methylcholanthrene in fish Google Scholar DOI
2018	Fernández I, Granadeiro L, Darias MJ, Gavaia P, Andree KB, Gisbert E. Solea senegalensis skeletal ossification and gene expression patterns during metamorphosis: New clues on the onset of skeletal deformities during larval to juvenile transition. Aquaculture. 2018;496:153 - 165. doi:10.1016/j.aquaculture.2018.07.022 Read more about Solea senegalensis skeletal ossification and gene expression patterns during metamorphosis: New clues on the onset of skeletal deformities during larval to juvenile transition Google Scholar DOI
2018	Carson MA, Nelson J, M. Cancela L, et al. Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. Cray JJ, ed. PLOS ONE. 2018;13(11):e0207303. doi:10.1371/journal.pone.0207303.s008 Read more about Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum Google Scholar DOI
2018	Fernández I, Gavaia P, Laizé V, M. Cancela L. Fish as a model to assess chemical toxicity in bone. Aquatic Toxicology. 2018;194:208 - 226. doi:10.1016/j.aquatox.2017.11.015 Read more about Fish as a model to assess chemical toxicity in bone Google Scholar DOI
2018	Fernandez I, Gavaia P, Darias M, Gisbert E. Fat-soluble vitamins in fish: A transcriptional tissue-specific crosstalk that remains to be unveiled and characterized. In: Emerging Issues In Fish Larvae Research. Emerging issues in fish larvae research. Springer International Publishing AG; 2018. Read more about Fat-soluble vitamins in fish: A transcriptional tissue-specific crosstalk that remains to be unveiled and characterized Google Scholar
2018	Gonçalves R, Tarasco M, Schatzmayr D, Gavaia P. Preliminary Evaluation of Moniliformin as a Potential Threat for Teleosts. Fishes. 2018;3(1):4. doi:10.3390/fishes3010004 Read more about Preliminary Evaluation of Moniliformin as a Potential Threat for Teleosts Google Scholar DOI
2018	Soares F, Roque A, Gavaia P. Review of the principal diseases affecting cultured meagre ( Argyrosomus regius). Aquaculture Research. 2018. doi:10.1111/are.13613 Read more about Review of the principal diseases affecting cultured meagre ( Argyrosomus regius) Google Scholar DOI
2018	Roberto VP, Gavaia P, Nunes MJ, Rodrigues E, M. Cancela L, Tiago DM. Evidences for a New Role of miR-214 in Chondrogenesis. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-21735-w Read more about Evidences for a New Role of miR-214 in Chondrogenesis Google Scholar DOI
2018	Roberto VP, Martins G, Pereira A, et al. Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13664 Read more about Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers Google Scholar DOI
2017	Carvalho FR, Fernandes AR, M. Cancela L, Gavaia P. Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet. Wound Repair and Regeneration. 2017;86(6):1796–1810. doi:10.1111/wrr.12536 Read more about Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet Google Scholar DOI
2017	Tarasco M, Laizé V, Cardeira J, M. Cancela L, Gavaia P. The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;197:45 - 52. doi:10.1016/j.cbpc.2017.04.006 Read more about The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance Google Scholar DOI
2017	Marques C, Roberto VP, Granadeiro L, et al. The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions. Marine Environmental Research. 2017;130:187-199. doi:10.1016/j.marenvres.2017.07.021 Read more about The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions Google Scholar DOI
2017	Boglione C, Gavaia P, Koumoundouros G, et al. Skeletal Anomalies in Reared European Fish Larvae and Juveniles. Part 1: Normal and Anomalous Skeletogenic Processes. In: Conceição LEC, Tandler A, eds. Success Factors For Fish Larval Production. Success Factors for Fish Larval Production. Wiley; 2017:219-254. https://books.google.pt/books?id=xV_HrQEACAAJ. Read more about Skeletal Anomalies in Reared European Fish Larvae and Juveniles. Part 1: Normal and Anomalous Skeletogenic Processes Google Scholar
2017	Boglione C, Gisbert E, Gavaia P, et al. Skeletal Anomalies in Reared European Fish Larvae and Juveniles. Part 2:Main Typologies, Occurrences and Causative Factors. In: Conceição LEC, Tandler A, eds. Success Factors For Fish Larval Production. Success Factors for Fish Larval Production. Wiley; 2017:255-330. https://books.google.pt/books?id=xV_HrQEACAAJ. Read more about Skeletal Anomalies in Reared European Fish Larvae and Juveniles. Part 2:Main Typologies, Occurrences and Causative Factors Google Scholar
2017	Riesco MF, Oliveira C, Soares F, Gavaia P, Dinis MT, Cabrita E. Solea senegalensis sperm cryopreservation: New insights on sperm quality. Prunet P, ed. PLOS ONE. 2017;12(10):e0186542. doi:10.1371/journal.pone.0186542.s003 Read more about Solea senegalensis sperm cryopreservation: New insights on sperm quality Google Scholar DOI
2016	Cardeira J, Gavaia P, Fernández I, et al. Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin. Scientific Reports. 2016;6:39191. doi:10.1038/srep39191 Read more about Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin Google Scholar DOI
2016	Fernández I, Gavaia P. Vitamin K, much more than blood clotting: An update on its roles, metabolism and requirements in fish species. In: Cruz-Suárez LE, Ricque-Marie D, Tapia-Salazar M, et al., eds. Nutrición Acuícola: Investigación Y Desarrollo. Nutrición Acuícola: Investigación y Desarrollo. Nuevo León, México: Universidad Autónoma de Nuevo León; 2016:361-376. Read more about Vitamin K, much more than blood clotting: An update on its roles, metabolism and requirements in fish species Google Scholar
2015	Cardeira J, Mendes AC, Pousão-Ferreira P, M. Cancela L, Gavaia P. Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis. J Fish Biol. 2015;86(6):1796-810. doi:10.1111/jfb.12686 Read more about Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis. Google Scholar PubMed DOI
2015	Rocha F, Dias J, Engrola S, et al. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. British Journal of Nutrition. 2015;113(03):403 - 413. doi:10.1017/S0007114514003869 Read more about Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life Google Scholar DOI
2015	Salas-Leiton E, Dias J, Gavaia P, Amoedo A, Valente LMP. Optimization of phosphorus content in high plant protein practical diets for Senegalese sole ( Solea senegalensis, Kaup 1858) juveniles: influence on growth performance and composition of whole body and vertebrae. Aquaculture Nutrition. 2015:n/a - n/a. doi:10.1111/anu.12354 Read more about Optimization of phosphorus content in high plant protein practical diets for Senegalese sole ( Solea senegalensis, Kaup 1858) juveniles: influence on growth performance and composition of whole body and vertebrae Google Scholar DOI
2015	Diogo P, Martins G, Gavaia P, et al. Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822). Journal of Applied Ichthyology. 2015;31:3 - 9. doi:10.1111/jai.2015.31.issue-S110.1111/jai.12733 Read more about Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822) Google Scholar DOI
2015	Fernández I, Vijayakumar P, Marques C, M. Cancela L, Gavaia P, Laizé V. Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish Physiology and Biochemistry. 2015;41(3):745-759. doi:10.1007/s10695-015-0043-z Read more about Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure Google Scholar DOI
2015	Fernández I, Cardeira J, Granadeiro L, Gavaia P, Laizé V, M. Cancela L. The use of in vivo imaging tools in zebrafish for drug discovery for bone development and homeostasis. Laboratory Animals. 2015;49:26 - 94. doi:10.1177/0023677215609551 Read more about The use of in vivo imaging tools in zebrafish for drug discovery for bone development and homeostasis Google Scholar DOI
2014	Laizé V, Gavaia P, M. Cancela L. Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. 2014;13:29-37. doi:10.1016/j.ddmod.2014.08.001 Read more about Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities Google Scholar DOI
2014	Rocha F, Dias J, Engrola S, et al. Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). J Exp Biol. 2014;217(Pt 7):1139-49. doi:10.1242/jeb.095463 Read more about Glucose overload in yolk has little effect on the long-term modulation of carbohydrate metabolic genes in zebrafish (Danio rerio). Google Scholar PubMed DOI
2014	Mateus M, Gamboa A, Ribeiro L, et al. Does copepods influence dusky grouper (Epinephelus marginatus) early development?. Frontiers in Marine Science. 2014;1. doi:10.3389/conf.FMARS.2014.02.00024 Read more about Does copepods influence dusky grouper (Epinephelus marginatus) early development? Google Scholar DOI
2014	Fernández I, Santos A, M. Cancela L, Laizé V, Gavaia P. Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins. Environmental Pollution. 2014;194:86-95. doi:10.1016/j.envpol.2014.07.015 Read more about Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins Google Scholar DOI
2014	Richard N, Fernández I, Wulff T, et al. Dietary supplementation with vitamin k affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Mar Biotechnol (NY). 2014;16(5):522-37. doi:10.1007/s10126-014-9571-2 Read more about Dietary supplementation with vitamin k affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Google Scholar PubMed DOI
2014	Soares F, Monzón I, Costas B, Gavaia P. Non-infectious Disorders of Warm water Fish Chapter 7. . In: Diseases And Disorders Of Finfish In Cage Culture. 2nd ed. Diseases and Disorders of Finfish in Cage Culture. ; 2014. Read more about Non-infectious Disorders of Warm water Fish Chapter 7. Google Scholar
2014	Cabrita E, Martínez-Páramo S, Gavaia P, et al. Factors enhancing fish sperm quality and emerging tools for sperm analysis. Aquaculture. 2014;432:389 - 401. doi:10.1016/j.aquaculture.2014.04.034 Read more about Factors enhancing fish sperm quality and emerging tools for sperm analysis Google Scholar DOI
2013	Adrião A, Conceicão N, Gavaia P, M. Cancela L. Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations. European Journal of Clinical Investigation. 2013;43:97 - 106. doi:10.1111/eci.2013.43.issue-s110.1111/eci.12088 Read more about Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations Google Scholar DOI
2013	Pinto W, Diogo P, Martins G, et al. Can dietary phospholipid and trace mineral supplementation influence zebrafish reproductive performance?. Commun Agric Appl Biol Sci. 2013;78(4):368-371. https://www.ncbi.nlm.nih.gov/pubmed/25141714. Read more about Can dietary phospholipid and trace mineral supplementation influence zebrafish reproductive performance? Google Scholar PubMed
2013	Simão M, Gavaia P, Pinto J, Korng E, M. Cancela L. Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism. Bone Abstracts. 2013. doi:10.1530/boneabs.1.PP262 Read more about Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism Google Scholar DOI
2013	Boglione C, Gavaia P, Koumoundouros G, et al. Skeletal anomalies in reared European fish larvae and juveniles. Part 1: normal and anomalous skeletogenic processes. Reviews in Aquaculture. 2013;5:S99 - S120. doi:10.1111/raq.2013.5.issue-s110.1111/raq.12015 Read more about Skeletal anomalies in reared European fish larvae and juveniles. Part 1: normal and anomalous skeletogenic processes Google Scholar DOI
2013	Boglione C, Gisbert E, Gavaia P, et al. Skeletal anomalies in reared European fish larvae and juveniles. Part 2: main typologies, occurrences and causative factors. Reviews in Aquaculture. 2013;5:S121 - S167. doi:10.1111/raq.2013.5.issue-s110.1111/raq.12016 Read more about Skeletal anomalies in reared European fish larvae and juveniles. Part 2: main typologies, occurrences and causative factors Google Scholar DOI
2013	Cunha ME, Ré P, Quental-Ferreira H, Gavaia P, Pousão-Ferreira P. Larval and juvenile development of dusky grouper Epinephelus marginatus reared in mesocosms. Journal of Fish Biology. 2013;83(3):448 - 465. doi:10.1111/jfb.2013.83.issue-310.1111/jfb.12180 Read more about Larval and juvenile development of dusky grouper Epinephelus marginatus reared in mesocosms Google Scholar DOI
2013	Pacchiarini T, Cross I, Leite RB, et al. Solea senegalensis vasa transcripts: molecular characterisation, tissue distribution and developmental expression profiles. Reprod Fertil Dev. 2013;25(4):646-60. doi:10.1071/RD11240 Read more about Solea senegalensis vasa transcripts: molecular characterisation, tissue distribution and developmental expression profiles. Google Scholar PubMed DOI
2013	Cunha ME, Ré P, Quental-Ferreira H, Gavaia P, Pousão-Ferreira P. Larval and juvenile development of dusky grouper Epinephelus marginatus reared in mesocosms. J Fish Biol. 2013;83(3):448-65. doi:10.1111/jfb.12180 Read more about Larval and juvenile development of dusky grouper Epinephelus marginatus reared in mesocosms. Google Scholar PubMed DOI
2012	Cardeira J, Bensimon-Brito A, Pousão-Ferreira P, M. Cancela L, Gavaia P. Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis). Journal of Applied Ichthyology. 2012;28(3):460 - 463. doi:10.1111/j.1439-0426.2012.01978.x Read more about Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis) Google Scholar DOI
2012	Richard N, Gavaia P, de Vareilles M, et al. Farm Animal Proteomicstwo-Dimensional Proteomics As A Tool To Evaluate Nutritional Effects In Farmed Fish. (Rodrigues P, Eckersall D, de Almeida A, eds.). Wageningen: Wageningen Academic Publishers; 2012:156 - 158. doi:10.3920/978-90-8686-751-6_37 Read more about Farm animal proteomicsTwo-dimensional proteomics as a tool to evaluate nutritional effects in farmed fish Google Scholar DOI
2012	Dionísio G, Campos C, Valente LMP, Conceição LEC, M. Cancela L, Gavaia P. Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis. Journal of Applied Ichthyology. 2012;28(3):471 - 476. doi:10.1111/j.1439-0426.2012.01996.x Read more about Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis Google Scholar DOI
2012	de Vareilles M, Richard N, Gavaia P, et al. Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae. Journal of Applied Ichthyology. 2012;28(3):477 - 487. doi:10.1111/j.1439-0426.2012.01986.x Read more about Impact of dietary protein hydrolysates on skeleton quality and proteome in Diplodus sargus larvae Google Scholar DOI
2012	Parameswaran V, Laizé V, Gavaia P, M. Cancela L. ESSA1 embryonic stem like cells from gilthead seabream: a new tool to study mesenchymal cell lineage differentiation in fish. Differentiation. 2012;84(3):240-51. doi:10.1016/j.diff.2012.07.004 Read more about ESSA1 embryonic stem like cells from gilthead seabream: a new tool to study mesenchymal cell lineage differentiation in fish. Google Scholar PubMed DOI
2012	Cardeira J, Vallés R, Dionísio G, et al. Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities. Journal of Applied Ichthyology. 2012;28(3):464 - 470. doi:10.1111/j.1439-0426.2012.01979.x Read more about Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities Google Scholar DOI
2011	Fonseca VG, Rosa J, Laizé V, Gavaia P, M. Cancela L. Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream. Gene Expr Patterns. 2011;11(7):448-55. doi:10.1016/j.gep.2011.07.003 Read more about Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream. Google Scholar PubMed DOI
2010	Cunha ME, Quental-Fereira H, Boglione C, , Gavaia P, Pousão-Fereira P. Rearing fish larvae for extensive and semi-intensive aquaculture - the “natural” mesocosms system. Aquaculture Europe 35 (2): 23-26. 2010. Read more about Rearing fish larvae for extensive and semi-intensive aquaculture - the “natural” mesocosms system Google Scholar
2010	Conceição LEC, Aragão C, Richard N, et al. Novel methodologies in marine fish larval nutrition. Fish Physiology and Biochemistry. 2010;36(1):1 - 16. doi:10.1007/s10695-009-9373-z Read more about Novel methodologies in marine fish larval nutrition Google Scholar DOI
2010	Dâmaso-Rodrigues MLuísa, Pousão-Ferreira P, Ribeiro L, et al. Lack of essential fatty acids in live feed during larval and post-larval rearing: effect on the performance of juvenile Solea senegalensis. Aquaculture International. 2010;18(5):741 - 757. doi:10.1007/s10499-009-9296-9 Read more about Lack of essential fatty acids in live feed during larval and post-larval rearing: effect on the performance of juvenile Solea senegalensis Google Scholar DOI
2009	Engrola S, Figueira L, Conceição LEC, Gavaia P, Ribeiro L, Dinis MT. Co-feeding in Senegalese sole larvae with inert diet from mouth opening promotes growth at weaning. Aquaculture. 2009;288(3-4):264 - 272. doi:10.1016/j.aquaculture.2008.12.010 Read more about Co-feeding in Senegalese sole larvae with inert diet from mouth opening promotes growth at weaning Google Scholar DOI
2009	Gavaia P, Domingues S, Engrola S, et al. Comparing skeletal development of wild and hatchery-reared Senegalese sole ( Solea senegalensis , Kaup 1858): evaluation in larval and postlarval stages. Aquaculture Research. 2009;40(14):1585 - 1593. doi:10.1111/are.2009.40.issue-1410.1111/j.1365-2109.2009.02258.x Read more about Comparing skeletal development of wild and hatchery-reared Senegalese sole ( Solea senegalensis , Kaup 1858): evaluation in larval and postlarval stages Google Scholar DOI
2009	Conceição LEC, Aragão C, Richard N, et al. Avanços recentes em nutrição de larvas de peixes. Revista Brasileira de Zootecnia. 2009;38(spe):26 - 35. doi:10.1590/S1516-35982009001300003 Read more about Avanços recentes em nutrição de larvas de peixes Google Scholar DOI
2009	Roberto VP, Cavaco S, Viegas CSB, et al. Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation. Aquaculture. 2009;294(3-4):202 - 211. doi:10.1016/j.aquaculture.2009.06.020 Read more about Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation Google Scholar DOI
2007	Brito ABB, M. Cancela L, Gavaia P. Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio). FEBS Journal. 2007;274:265 - 306. doi:10.1111/ejb.2007.274.issue-s110.1111/j.0014-2956.2007.05861_6.x Read more about Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio) Google Scholar DOI
2007	Rønnestad I, Gavaia P, Viegas CSB, et al. Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. J Exp Biol. 2007;210(Pt 22):3883-96. doi:10.1242/jeb.007898 Read more about Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. Google Scholar PubMed DOI
2007	Stefanni S, Porteiro FM, Bettencourt R, Gavaia P, Santos RS. Molecular insights indicate that Pachycara thermophilum (Geistdoerfer, 1994) and P. saldanhai (Biscoito and Almeida, 2004) (Perciformes: Zoarcidae) from the Mid-Atlantic Ridge are synonymous species. Molecular Phylogenetics and Evolution. 2007;45(1):423 - 426. doi:10.1016/j.ympev.2007.02.001 Read more about Molecular insights indicate that Pachycara thermophilum (Geistdoerfer, 1994) and P. saldanhai (Biscoito and Almeida, 2004) (Perciformes: Zoarcidae) from the Mid-Atlantic Ridge are synonymous species Google Scholar DOI
2007	Pittman K, Rønnestad I, Gavaia P, et al. Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms. Aquaculture Europe . 2007;32(5). Read more about Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms Google Scholar
2007	Stefanni S, Porteiro FM, Bettencourt R, Gavaia P, Santos RS. Molecular insights indicate that Pachycara thermophilum () and P. saldanhai () (Perciformes: Zoarcidae) from the Mid-Atlantic Ridge are synonymous species. Mol Phylogenet Evol. 2007;45(1):423-6. doi:10.1016/j.ympev.2007.02.001 Read more about Molecular insights indicate that Pachycara thermophilum () and P. saldanhai () (Perciformes: Zoarcidae) from the Mid-Atlantic Ridge are synonymous species. Google Scholar PubMed DOI
2006	Simões B, Conceição N, Viegas CSB, et al. Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Calcif Tissue Int. 2006;79(4):230-44. doi:10.1007/s00223-006-0111-6 Read more about Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Google Scholar PubMed DOI
2006	Gavaia P, Simes DC, Ortiz-Delgado JB, et al. Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Gene Expr Patterns. 2006;6(6):637-52. doi:10.1016/j.modgep.2005.11.010 Read more about Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Google Scholar PubMed DOI
2005	Engrola S, Conceição LEC, Gavaia P, M. Cancela L, Dinis MTeresa. Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858). Israeli Journal of Aquaculture . 2005;57(1). Read more about Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858) Google Scholar
2005	Ortiz-Delgado JB, Simes DC, Gavaia P, Sarasquete C, M. Cancela L. Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution. Histochem Cell Biol. 2005;124(2):123-30. doi:10.1007/s00418-005-0015-y Read more about Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution. Google Scholar PubMed DOI
2004	Simes DC, Williamson MK, Schaff BJ, et al. Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Calcif Tissue Int. 2004;74(2):170-80. doi:10.1007/s00223-003-0079-4 Read more about Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Google Scholar PubMed DOI
2003	Pinto JP, Conceição N, Gavaia P, M. Cancela L. Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata. Bone. 2003;32(3):201-10. Read more about Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata. Google Scholar PubMed
2003	Gavaia P, Ortiz JB, Simes DC, Sarasquete MC, M. Cancela L. SIMULTANEOUS DETECTION OF OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPMENTAL STAGES OF ZEBRA FISH (DANIO RERIO). Calcified Tissue International. 2003;72:314 - 468. doi:10.1007/s00223-003-5002-5 Read more about SIMULTANEOUS DETECTION OF OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPMENTAL STAGES OF ZEBRA FISH (DANIO RERIO) Google Scholar DOI
2002	Gavaia P, Dinis MT, M. Cancela L. Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis). Aquaculture. 2002;211(1-4):305 - 323. doi:10.1016/S0044-8486(02)00167-9 Read more about Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis) Google Scholar DOI
2001	Gavaia P, Viegas CSB, Pinto JP, Sarasquete MC, M. Cancela L. DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY. Bone. 2001;28:S101 - S248. doi:10.1016/S8756-3282(01)00454-9 Read more about DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY Google Scholar DOI
2000	Gavaia P, Sarasquete C, M. Cancela L. Detection of Mineralized Structures in Early Stages of Development of Marine Teleostei Using a Modified Alcian Blue-Alizarin Red Double Staining Technique for Bone and Cartilage. Biotechnic & Histochemistry. 2000;75(2):79 - 84. doi:10.3109/10520290009064151 Read more about Detection of Mineralized Structures in Early Stages of Development of Marine Teleostei Using a Modified Alcian Blue-Alizarin Red Double Staining Technique for Bone and Cartilage Google Scholar DOI