Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia.

de Vernejoul, M C; Girot, R; Gueris, J; M. Leonor Cancela; Bang, S; Bielakoff, J; Mautalen, C; Goldberg, D; Miravet, L; Yúfera, M.; Conceição, L.; M. Leonor Cancela; Dossat, Carole; Favrel, Pascal; Huvet, Arnaud; Jarque, Sergio; Jollivet, Didier; Klages, Sven; Lapègue, Sylvie; Leite, Ricardo; Moal, Jeanne; Moraga, Dario; Reinhardt, Richard; Samain, Jean-François; Zouros, Eleftherios; Adelino V.M. Canario

Leonor Cancela

Posição

Senior Researcher

Grau Académico

Agregação

Líder do Grupo

Comparative, Adaptive and Functional Skeletal Biology

Grupo

Comparative, Adaptive and Functional Skeletal Biology

Categoria

Full Professor

Instituição

Department of Biomedical Sciences and Medicine, University of Algarve, Faro 8005-139 Faro, Portugal

Localização

Faro, Gambelas Campus, UAlg

Gabinete

2.54 C2

Contacto

+351 289800971

Extensão

7971

lcancela@ualg.pt

Keywords

skeletal development, bone biology, bone diseases, gene regulation, gene transcription, vitamin K, Gla proteins, fish models of human diseases, marine derived compounds for biotechnological applications

ORCID ID

ResearchGate

Organiza

Informação Principal

Academic degrees, fields of study, awarding institutions, dates

2003: Agregação, Molecular and Celular Biology, University of Algarve (by unanimity)

1985: PhD - "Docteur de l’Université Pierre et Marie Curie, Mention Très honorable", Paris, France

1982: Diplôme dÉtudes Approfondies (DEA) in Biochemistry, University Paris VI, Paris, France

1981: Maîtrise - "Biology of Organisms and Populations, option Animal Biology "- Paris VI - France

Current position: Full Professor, University of Algarve / Dept of Biomedical Sciences and Medicine

Previous positions, institutions, dates in reverse chronological order

April 06 Full Professor, University of Algarve

Jan/April 2000: Visiting Associate Project Scientist, Department of Biology, University of California San Diego, La Jolla, CA, USA.

Nov 98/Mar 06: Associate Professor, University of Algarve

Nov 92/Oct 98: Assistant Professor, University of Algarve

Jul 91/Oct 92: Assistant Research Biologist, Univ. California, San Diego, California, USA.

Feb 88/Jun 91: Post Doctoral Fellow, University of California, San Diego, California, USA.

Jan 86/Jan 88: Post Doctoral Fellow, University of California, Riverside, California, USA.

Jul 85/Dec 85: Post Doctoral Biochemist, INSERM, Hôpital Lariboisière, Paris, France.

Current research interests

Main: Control of gene expression of vitamin K-dependent matrix proteins during vertebrate development and onset of skeletogenesis. Molecular determinants of mineralization. Evolution of bone and cartilage, implications in onset of skeletal adaptations. Fish as model organism for skeletal related human pathologies (Paget disease of bone, osteoporosis) including rare diseases (Keutel syndrome, Mef2c and MRD20 Syndrome).

Others: Biotechnological applications of marine resources, identification of molecules with mineralogenic properties in collaboration with pharmaceutical companies.

International/National Commitments /evaluator: Member of evaluation committees of projectos and fellowships for (i) international research agencies in France (ANR), Netherlands(NWO), UK (British Council) and European Commission (ERC-LS9 panel since 2008); and (ii) national agencies (FCT, Medals l’Oreal, fellowships/prizes awarded by portuguese societies). Regular referee for international jounals

Training: Coordinated: 18 postdocs, 24 PhD students (23 finished, 1 ongoing); 24 Master thesis (1 ongoing); >50 undergraduate research projects from degrees in Biology, Biotechnology, Marine Biology, Biochemistry, Biomedical Sciences and Medicine

Citation metrics: http://www.researcherid.com/rid/F-4665-2012 / ORCID: 0000-0003-3114-6662

International Publications and Patents: 162 peer review publications, 15 book chapters and two book editions (in Portuguese).5 int. patents

Projetos

Coordenação de Projetos

	Título	Coordenador	Início	Fim	Financiamento	Orçamento
Zfscreen	Screening for molecules capable of rescuing CDKL5 deficiency phenotypes using Zebrafish models	Leonor Cancela	01/2023	07/2024	FCT - Fundação para a Ciência e Tecnologia	49858k€
CDKL5	Rescuing functional defects in a zebrafish model of CDKL5 deficiency: Contribution to the identification of therapeutic targets	Leonor Cancela	05/2022	04/2023
Physpath-KS	Estudo da patologia e fisiologia da Síndrome de Keutel: Implicações para a cura	Leonor Cancela	04/2020	03/2024	FCT - Fundação para a Ciência e Tecnologia
IsopPerk	Caracterização da biossíntese de isoprenoides e determinação de potenciais alvos terapêuticos	Leonor Cancela	08/2007	07/2010	FCT - Fundação para a Ciência e Tecnologia	161k€
PTARGET	Caracterização dos metabolismos do ácido fólico e das purinas no protozoário parasita Perkinsus atlanticus: identificação dos genes envolvidos na sua biossintese e potenciais alvos terapêuticos.	Leonor Cancela	06/2005	05/2008	FCT - Fundação para a Ciência e Tecnologia	85k€

Projects Membership

	Título	Coordenador	Início	Fim	Orçamento	Orçamento Total
DEEPBONE	DEEPBONE - Biologia do osso de peixes de profundidade	Vincent Laizé	01/2012	06/2015	109k€	109k€
SPECIAL_K	Efeitos da suplementação nutricional em vitamina K no crescimento e desenvolvimento esquelético de peixes teleósteos	Paulo Jorge Travessa Gavaia	02/2010	07/2013	195k€	195107k€
SaMGP	Effect of extracellular calcium on MGP gene expression	Vincent Laizé	03/2003	03/2006	100k€	100k€

Eventos

Tipo de Evento

Outros Eventos

CCMAR recebe grupo de alunos da Universidade de Verão de Shou (China)

De 11 a 29 de Julho, 25 alunos da Universidade de Verão de Shou (China) vão ser acolhidos no Centro de Ciências do Mar (CCMAR) para acompanhar o trabalho dos nossos investigadores.

Seg, 11/07/2016

Local

Bldg. 7 - Gambelas Campus

Tipo de Evento

Outros Eventos

Get together CCMAR / Farewell party

Join us to a farewell party with the students from Summer School Shou (China). We're waiting for you!

Sex, 29/07/2016

Local

Building 7 - main hall

Tipo de Evento

Outros Eventos

Get together CCMAR / Welcome party

Next week, join us to welcome the students from Summer School Shou (China). We're waiting for you!

Seg, 11/07/2016

Local

Building 7 - main hall

ATT: Using Zebrafish as a model in Biomedicine and study of human diseases - 3rd Edition

21st April 2017 Organization: CCMAR Location: Universidade do Algarve - Campus de Gambelas (limited places)

Grupo

Comparative, Adaptive and Functional Skeletal Biology

Sex, 21/04/2017

Local

CCMAR - Universidade do Algarve - Campus de Gambelas (Faro)

Notícias

News

Investigadores do CCMAR no caminho da regeneração e formação óssea

Com mais esta descoberta, os investigadores acreditam estar cada vez mais perto de novas terapêuticas para doenças ósseas como a osteoporose, que é caraterizada pela perda de massa óssea. O trabalho recentemente publicado pelos cientistas do Centro de Ciências do Mar (CCMAR) deve inclusivamente tornar-se a breve prazo uma referência para a identificação deste tipo de moléculas.

Ler mais

CCMAR @t media: Os peixes podem ajudar a combater a osteoporose?

"O peixe zebra consegue regenerar a sua barbatana caudal, apesar desta ser feita de tecido e osso como os membros dos demais animais e, claro, dos seres humanos. Uma particularidade que foi investigada pelo grupo Bioskel, do Centro de Ciências do Mar (CCMar) do Algarve, e que pode vir a dar pistas decisivas para a criação de terapias que permitam combater diferentes doenças ósseas, entre as quais a osteoporose".

Ler mais

Especialistas discutem esqueleto e problemas ósseos esta semana

O CCMAR organiza esta semana a 5ª edição da Conferência “Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB)” em Tavira, Portugal.

Ler mais

Publicações

Year of Publication
2019	Fernández I, Fernandes JMO, Roberto VP, et al. Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish. Biochimica et Biophysica Acta (BBA) - General Subjects. 2019;1863(1):39-51. doi:10.1016/j.bbagen.2018.09.017 Ler mais acerca de Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish Google Scholar DOI
2019	Carvalho FR, Calado SM, Silva GA, et al. Altered bone microarchitecture in a type 1 diabetes mouse model Ins2 ^Akita. Journal of Cellular Physiology. 2019;234(6):9338-9350 . doi:10.1002/jcp.27617 Ler mais acerca de Altered bone microarchitecture in a type 1 diabetes mouse model Ins2 Akita Google Scholar DOI
2018	Silva IAL, Conceição N, Gagnon E, Brown JP, M. Cancela L, Michou L. Molecular effect of an OPTN common variant associated to Paget's disease of bone. PLOS ONE. 2018;13(5):e0197543. doi:10.1371/journal.pone.0197543.s007 Ler mais acerca de Molecular effect of an OPTN common variant associated to Paget's disease of bone Google Scholar DOI
2018	Vitorino M, Cunha N, Conceição N, M. Cancela L. Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome. Molecular Biology Reports. 2018. doi:10.1007/s11033-018-4180-1 Ler mais acerca de Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome Google Scholar DOI
2018	Vitorino M, Conceição N, M. Cancela L. Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome. Journal of Applied Ichthyology. 2018;34(2):489 - 500. doi:10.1111/jai.13667 Ler mais acerca de Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome Google Scholar DOI
2018	Silva IAL, Conceição N, Gagnon E, et al. Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018;1864(1):143 - 151. doi:10.1016/j.bbadis.2017.10.008 Ler mais acerca de Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone Google Scholar DOI
2018	Fernández I, Gavaia P, Laizé V, M. Cancela L. Fish as a model to assess chemical toxicity in bone. Aquatic Toxicology. 2018;194:208 - 226. doi:10.1016/j.aquatox.2017.11.015 Ler mais acerca de Fish as a model to assess chemical toxicity in bone Google Scholar DOI
2018	Rosa J, Cox CJ, M. Cancela L, Laizé V. Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism. Gene. 2018;645:137 - 145. doi:10.1016/j.gene.2017.12.021 Ler mais acerca de Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism Google Scholar DOI
2018	Roberto VP, Gavaia P, Nunes MJ, Rodrigues E, M. Cancela L, Tiago DM. Evidences for a New Role of miR-214 in Chondrogenesis. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-21735-w Ler mais acerca de Evidences for a New Role of miR-214 in Chondrogenesis Google Scholar DOI
2018	Roberto VP, Martins G, Pereira A, et al. Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13664 Ler mais acerca de Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers Google Scholar DOI
2018	Fazenda C, Martins G, Gavaia P, M. Cancela L, Conceição N. Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13662 Ler mais acerca de Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein Google Scholar DOI
2018	Cardeira J, Laizé V, Martins G, M. Cancela L, Gavaia P. An overview on the teleost bone mechanophysiology. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13661 Ler mais acerca de An overview on the teleost bone mechanophysiology Google Scholar DOI
2018	Ferreira-Rodríguez N, Fernández I, M. Cancela L, Pardo I. Multibiomarker response shows how native and non-native freshwater bivalves differentially cope with heat-wave events. Aquatic Conservation: Marine and Freshwater Ecosystems. 2018. doi:10.1002/aqc.2884 Ler mais acerca de Multibiomarker response shows how native and non-native freshwater bivalves differentially cope with heat-wave events Google Scholar DOI
2018	Carson MA, Nelson J, M. Cancela L, et al. Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-26024-0 Ler mais acerca de Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae Google Scholar DOI
2018	Laizé V, Gavaia P, Tarasco M, et al. Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and Environmental Safety. 2018;161:721 - 728. doi:10.1016/j.ecoenv.2018.06.035 Ler mais acerca de Osteotoxicity of 3-methylcholanthrene in fish Google Scholar DOI
2017	Surget G, Roberto VP, Le Lann K, et al. Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities. Journal of Applied Phycology. 2017;29:575-584. doi:10.1007/s10811-016-0968-3 Ler mais acerca de Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities Google Scholar DOI
2017	Carvalho FR, Fernandes AR, M. Cancela L, Gavaia P. Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet. Wound Repair and Regeneration. 2017;86(6):1796–1810. doi:10.1111/wrr.12536 Ler mais acerca de Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet Google Scholar DOI
2017	Tarasco M, Laizé V, Cardeira J, M. Cancela L, Gavaia P. The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;197:45 - 52. doi:10.1016/j.cbpc.2017.04.006 Ler mais acerca de The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance Google Scholar DOI
2017	Marques C, Roberto VP, Granadeiro L, et al. The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions. Marine Environmental Research. 2017;130:187-199. doi:10.1016/j.marenvres.2017.07.021 Ler mais acerca de The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions Google Scholar DOI
2016	Medeiros MCR, Mestre A, Inácio P, et al. An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes. Sensing and Bio-Sensing Research. 2016;10:1 - 8. doi:10.1016/j.sbsr.2016.06.002 Ler mais acerca de An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes Google Scholar DOI
2016	Cardeira J, Gavaia P, Fernández I, et al. Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin. Scientific Reports. 2016;6:39191. doi:10.1038/srep39191 Ler mais acerca de Quantitative assessment of the regenerative and mineralogenic performances of the zebrafish caudal fin Google Scholar DOI
2016	Correia E, Conceição N, M. Cancela L, Belo JA. Matrix Gla Protein expression pattern in the early avian embryo. Int J Dev Biol. 2016;60(1-3):71-6. doi:10.1387/ijdb.150365jb Ler mais acerca de Matrix Gla Protein expression pattern in the early avian embryo. Google Scholar PubMed DOI
2016	Ferreira-Rodríguez N, Fernández I, Varandas S, Cortes R, M. Cancela L, Pardo I. The role of calcium concentration in the invasive capacity of Corbicula fluminea in crystalline basins. Science of The Total Environment. 2016. doi:10.1016/j.scitotenv.2016.12.100 Ler mais acerca de The role of calcium concentration in the invasive capacity of Corbicula fluminea in crystalline basins Google Scholar DOI
2016	Divisato G, Formicola D, Esposito T, et al. ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. Am J Hum Genet. 2016;98(2):275-86. doi:10.1016/j.ajhg.2015.12.016 Ler mais acerca de ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. Google Scholar PubMed DOI
2016	Rosa J, Tiago DM, Marques CL, et al. Central role of betaine–homocysteine S-methyltransferase 3 in chondral ossification and evidence for sub-functionalization in neoteleost fish. Biochimica et Biophysica Acta (BBA) - General Subjects. 2016;1860(7):1373-1387. doi:10.1016/j.bbagen.2016.03.034 Ler mais acerca de Central role of betaine–homocysteine S-methyltransferase 3 in chondral ossification and evidence for sub-functionalization in neoteleost fish Google Scholar DOI
2016	Marques CL, M. Cancela L, Laizé V. Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors. Gene. 2016;576(1 Pt 2):229-236. doi:10.1016/j.gene.2015.10.005 Ler mais acerca de Transcriptional regulation of gilthead seabream bone morphogenetic protein (BMP) 2 gene by bone- and cartilage-related transcription factors Google Scholar PubMed DOI
2016	Tiago DM, Conceição N, Caiado H, Laizé V, M. Cancela L. Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells. FEBS Letters. 2016;590(8):1234-1241. doi:10.1002/1873-3468.12155 Ler mais acerca de Matrix Gla protein repression by miR-155 promotes oncogenic signals in breast cancer MCF-7 cells Google Scholar PubMed DOI
2016	Bensimon-Brito A, Cardeira J, Dionísio G, Huysseune A, M. Cancela L, Witten PE. Revisiting in vivo staining with alizarin red S--a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration. BMC Dev Biol. 2016;16:2. doi:10.1186/s12861-016-0102-4 Ler mais acerca de Revisiting in vivo staining with alizarin red S--a valuable approach to analyse zebrafish skeletal mineralization during development and regeneration. Google Scholar PubMed DOI
2016	Marques CL, Fernández I, Viegas MN, et al. Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives. Cellular and Molecular Life Sciences. 2016;73(4):841-857. doi:10.1007/s00018-015-2024-x Ler mais acerca de Comparative analysis of zebrafish bone morphogenetic proteins 2, 4 and 16: molecular and evolutionary perspectives Google Scholar DOI
2016	Adrião A, Conceição N, M. Cancela L. MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation. Arch Biochem Biophys. 2016;591:43-56. doi:10.1016/j.abb.2015.12.004 Ler mais acerca de MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation. Google Scholar PubMed DOI
2015	Rodrigues ET, Pardal MÂ, Laizé V, M. Cancela L, Oliveira PJ, Serafim TL. Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin. Environ Pollut. 2015;206:619-26. doi:10.1016/j.envpol.2015.08.026 Ler mais acerca de Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin. Google Scholar PubMed DOI
2015	Fernández I, Vijayakumar P, Marques C, M. Cancela L, Gavaia P, Laizé V. Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish Physiology and Biochemistry. 2015;41(3):745-759. doi:10.1007/s10695-015-0043-z Ler mais acerca de Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure Google Scholar DOI
2015	Fazenda C, Conceição N, M. Cancela L. Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene. Gene. 2015;572(1):57-62. doi:10.1016/j.gene.2015.06.079 Ler mais acerca de Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene. Google Scholar PubMed DOI
2015	Cardeira J, Mendes AC, Pousão-Ferreira P, M. Cancela L, Gavaia P. Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis. J Fish Biol. 2015;86(6):1796-810. doi:10.1111/jfb.12686 Ler mais acerca de Micro-anatomical characterization of vertebral curvatures in Senegalese sole Solea senegalensis. Google Scholar PubMed DOI
2015	Roberto VP, Tiago DM, Gautvik K, M. Cancela L. Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Gene. 2015;566(1):54-62. doi:10.1016/j.gene.2015.04.022 Ler mais acerca de Evidence for the conservation of miR-223 in zebrafish (Danio rerio): Implications for function. Google Scholar PubMed DOI
2015	Simões B, Conceição N, Matias AC, Bragança J, Kelsh RN, M. Cancela L. Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function. Arch Biochem Biophys. 2015;567:1-12. doi:10.1016/j.abb.2014.12.023 Ler mais acerca de Molecular characterization of cbfβ gene and identification of new transcription variants: implications for function. Google Scholar PubMed DOI
2015	Fernández I, Cardeira J, Granadeiro L, Gavaia P, Laizé V, M. Cancela L. The use of in vivo imaging tools in zebrafish for drug discovery for bone development and homeostasis. Laboratory Animals. 2015;49:26 - 94. doi:10.1177/0023677215609551 Ler mais acerca de The use of in vivo imaging tools in zebrafish for drug discovery for bone development and homeostasis Google Scholar DOI
2015	Camacho A, Funck-Brentano T, Simão M, et al. Effect of C282Y genotype on self-reported musculoskeletal complications in hereditary hemochromatosis. PLoS One. 2015;10(3):e0122817. doi:10.1371/journal.pone.0122817 Ler mais acerca de Effect of C282Y genotype on self-reported musculoskeletal complications in hereditary hemochromatosis. Google Scholar PubMed DOI
2015	Diogo P, Martins G, Gavaia P, et al. Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822). Journal of Applied Ichthyology. 2015;31:3 - 9. doi:10.1111/jai.2015.31.issue-S110.1111/jai.12733 Ler mais acerca de Assessment of nutritional supplementation in phospholipids on the reproductive performance of zebrafish, Danio rerio (Hamilton, 1822) Google Scholar DOI
2014	Fernández I, Santos A, M. Cancela L, Laizé V, Gavaia P. Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins. Environmental Pollution. 2014;194:86-95. doi:10.1016/j.envpol.2014.07.015 Ler mais acerca de Warfarin, a potential pollutant in aquatic environment acting through Pxr signaling pathway and γ-glutamyl carboxylation of vitamin K-dependent proteins Google Scholar DOI
2014	Marques CL, Fernández I, Rosa J, Viegas MN, M. Cancela L, Laizé V. Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole. Journal of Applied Ichthyology. 2014;30(4):713-720. doi:10.1111/jai.2014.30.issue-410.1111/jai.12539 Ler mais acerca de Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole Google Scholar DOI
2014	Rosa JT, M. Cancela L, Laizé V. Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream. Journal of Applied Ichthyology. 2014;30(4):707-712. doi:10.1111/jai.2014.30.issue-410.1111/jai.12534 Ler mais acerca de Ets1 regulates the transcription of a cartilage-specific S100 protein in gilthead seabream Google Scholar DOI
2014	Fernández I, Tiago DM, Laizé V, M. Cancela L, Gisbert E. Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins. Journal of Steroid Biochemistry and Molecular Biology. 2014;140:34-43. doi:10.1016/j.jsbmb.2013.11.012 Ler mais acerca de Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: Different gene expression of nuclear receptors and ECM proteins Google Scholar DOI
2014	Roberto VP, Tiago DM, Silva IAL, M. Cancela L. MiR-29a is an enhancer of mineral deposition in bone-derived systems. Arch Biochem Biophys. 2014;564:173-83. doi:10.1016/j.abb.2014.09.006 Ler mais acerca de MiR-29a is an enhancer of mineral deposition in bone-derived systems. Google Scholar PubMed DOI
2014	Silva IAL, Cox CJ, Leite RB, M. Cancela L, Conceição N. Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Comp Biochem Physiol B Biochem Mol Biol. 2014;172-173:9-20. doi:10.1016/j.cbpb.2014.03.007 Ler mais acerca de Evolutionary conservation of TFIIH subunits: implications for the use of zebrafish as a model to study TFIIH function and regulation. Google Scholar PubMed DOI
2014	Cavaco S, Williamson MK, Rosa J, et al. Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Fish Physiol Biochem. 2014;40(3):731-8. doi:10.1007/s10695-013-9880-9 Ler mais acerca de Teleost fish osteocalcin 1 and 2 share the ability to bind the calcium mineral phase. Google Scholar PubMed DOI
2014	Tiago DM, Marques CL, Roberto VP, M. Cancela L, Laizé V. Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish. Arch Biochem Biophys. 2014;543:23-30. doi:10.1016/j.abb.2013.12.009 Ler mais acerca de Mir-20a regulates in vitro mineralization and BMP signaling pathway by targeting BMP-2 transcript in fish. Google Scholar PubMed DOI
2014	Richard N, Fernández I, Wulff T, et al. Dietary supplementation with vitamin k affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Mar Biotechnol (NY). 2014;16(5):522-37. doi:10.1007/s10126-014-9571-2 Ler mais acerca de Dietary supplementation with vitamin k affects transcriptome and proteome of Senegalese sole, improving larval performance and quality. Google Scholar PubMed DOI
2014	M. Cancela L, Laizé V, Conceição N. Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization. Arch Biochem Biophys. 2014;561:56-63. doi:10.1016/j.abb.2014.07.020 Ler mais acerca de Matrix Gla protein and osteocalcin: from gene duplication to neofunctionalization. Google Scholar PubMed DOI
2014	Laizé V, Gavaia P, M. Cancela L. Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities. Drug Discovery Today: Disease Models. 2014;13:29-37. doi:10.1016/j.ddmod.2014.08.001 Ler mais acerca de Fish: a suitable system to model human bone disorders and discover drugs with osteogenic or osteotoxic activities Google Scholar DOI
2014	Simões B, Conceição N, Kelsh RN, M. Cancela L. Identification of cis -regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: implications for function. Journal of Applied Ichthyology. 2014;30(4):661 - 670. doi:10.1111/jai.2014.30.issue-410.1111/jai.12536 Ler mais acerca de Identification of cis -regulatory elements in the upstream regions of zebrafish runx3 through in silico analysis: implications for function Google Scholar DOI
2014	Silva IAL, Conceição N, Michou L, M. Cancela L. Can zebrafish be a valid model to study Paget's disease of bone?. Journal of Applied Ichthyology. 2014;30(4):678 - 688. doi:10.1111/jai.2014.30.issue-410.1111/jai.12523 Ler mais acerca de Can zebrafish be a valid model to study Paget's disease of bone? Google Scholar DOI
2013	Simão M, Gavaia P, Pinto J, Korng E, M. Cancela L. Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism. Bone Abstracts. 2013. doi:10.1530/boneabs.1.PP262 Ler mais acerca de Establishing an in vitro system to study chondrocyte phenotypes associated to human hereditary hemochromatosis and identify molecular players involved in chondrocyte related iron metabolism Google Scholar DOI
2013	Leite RB, Milan M, Coppe A, et al. mRNA-Seq and microarray development for the Grooved Carpet shell clam, Ruditapes decussatus: a functional approach to unravel host-parasite interaction. BMC Genomics. 2013;14:741. doi:10.1186/1471-2164-14-741 Ler mais acerca de mRNA-Seq and microarray development for the Grooved Carpet shell clam, Ruditapes decussatus: a functional approach to unravel host-parasite interaction. Google Scholar PubMed DOI
2013	Vijayakumar P, Laizé V, Cardeira J, Trindade M, M. Cancela L. Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization. Zebrafish. 2013;10(4):500-9. doi:10.1089/zeb.2012.0833 Ler mais acerca de Development of an in vitro cell system from zebrafish suitable to study bone cell differentiation and extracellular matrix mineralization. Google Scholar PubMed DOI
2013	Viegas CSB, Simes DC, Williamson MK, et al. Sturgeon osteocalcin shares structural features with matrix Gla protein: evolutionary relationship and functional implications. J Biol Chem. 2013;288(39):27801-11. doi:10.1074/jbc.M113.450213 Ler mais acerca de Sturgeon osteocalcin shares structural features with matrix Gla protein: evolutionary relationship and functional implications. Google Scholar PubMed DOI
2013	Adrião A, Conceicão N, Gavaia P, M. Cancela L. Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations. European Journal of Clinical Investigation. 2013;43:97 - 106. doi:10.1111/eci.2013.43.issue-s110.1111/eci.12088 Ler mais acerca de Zebrafish as a model to study craniofacial phenotypes related to human MEF2C mutations Google Scholar DOI
2013	Araujo NCP, Afonso R, Bringela A, M. Cancela L, Cristiano MLS, Leite RB. Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves. Parasitol Int. 2013;62(6):575-82. doi:10.1016/j.parint.2013.06.010 Ler mais acerca de Peroxides with antiplasmodial activity inhibit proliferation of Perkinsus olseni, the causative agent of Perkinsosis in bivalves. Google Scholar PubMed DOI
2013	Conceição N, Viegas M, Fidalgo J, M. Cancela L. Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture. Mol Cell Biochem. 2013;373(1-2):41-51. doi:10.1007/s11010-012-1473-x Ler mais acerca de Development and characterization of Xl1, a Xenopus laevis chondrocyte-like cell culture. Google Scholar PubMed DOI
2012	Michou L, Conceição N, Morissette J, et al. Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone. Bone. 2012;51(4):720-8. doi:10.1016/j.bone.2012.06.028 Ler mais acerca de Genetic association study of UCMA/GRP and OPTN genes (PDB6 locus) with Paget's disease of bone. Google Scholar PubMed DOI
2012	M. Cancela L, Conceição N, Laizé V. Gla-rich protein, a new player in tissue calcification?. Adv Nutr. 2012;3(2):174-81. doi:10.3945/an.111.001685 Ler mais acerca de Gla-rich protein, a new player in tissue calcification? Google Scholar PubMed DOI
2012	Rafael MS, Laizé V, Florindo C, Ferraresso S, Bargelloni L, M. Cancela L. Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts. Biochimie. 2012;94(5):1128-34. doi:10.1016/j.biochi.2012.01.013 Ler mais acerca de Overexpression of four and a half LIM domains protein 2 promotes epithelial-mesenchymal transition-like phenotype in fish pre-osteoblasts. Google Scholar PubMed DOI
2012	Cardeira J, Vallés R, Dionísio G, et al. Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities. Journal of Applied Ichthyology. 2012;28(3):464 - 470. doi:10.1111/j.1439-0426.2012.01979.x Ler mais acerca de Osteology of the axial and appendicular skeletons of the meagre Argyrosomus regius (Sciaenidae) and early skeletal development at two rearing facilities Google Scholar DOI
2012	Viegas MN, Dias J, M. Cancela L, Laizé V. Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line. Journal of Applied Ichthyology. 2012;28(3):427-432. doi:10.1111/j.1439-0426.2012.01994.x Ler mais acerca de Polyunsaturated fatty acids regulate cell proliferation, extracellular matrix mineralization and gene expression in a gilthead seabream skeletal cell line Google Scholar DOI
2012	Silva IAL, M. Cancela L, Conceição N. Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). Mol Biol Rep. 2012;39(5):5339-48. doi:10.1007/s11033-011-1333-x Ler mais acerca de Molecular cloning and expression analysis of xpd from zebrafish (Danio rerio). Google Scholar PubMed DOI
2012	Cardeira J, Bensimon-Brito A, Pousão-Ferreira P, M. Cancela L, Gavaia P. Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis). Journal of Applied Ichthyology. 2012;28(3):460 - 463. doi:10.1111/j.1439-0426.2012.01978.x Ler mais acerca de Lordotic-kyphotic vertebrae develop ectopic cartilage-like tissue in Senegalese sole (Solea senegalensis) Google Scholar DOI
2012	Rafael MS, Laizé V, Bensimon-Brito A, Leite RB, Schüle R, M. Cancela L. Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Cell Mol Life Sci. 2012;69(3):423-34. doi:10.1007/s00018-011-0754-y Ler mais acerca de Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Google Scholar PubMed DOI
2012	Dionísio G, Campos C, Valente LMP, Conceição LEC, M. Cancela L, Gavaia P. Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis. Journal of Applied Ichthyology. 2012;28(3):471 - 476. doi:10.1111/j.1439-0426.2012.01996.x Ler mais acerca de Effect of egg incubation temperature on the occurrence of skeletal deformities in Solea senegalensis Google Scholar DOI
2012	Parameswaran V, Laizé V, Gavaia P, M. Cancela L. ESSA1 embryonic stem like cells from gilthead seabream: a new tool to study mesenchymal cell lineage differentiation in fish. Differentiation. 2012;84(3):240-51. doi:10.1016/j.diff.2012.07.004 Ler mais acerca de ESSA1 embryonic stem like cells from gilthead seabream: a new tool to study mesenchymal cell lineage differentiation in fish. Google Scholar PubMed DOI
2012	Bensimon-Brito A, Cardeira J, M. Cancela L, Huysseune A, Witten PEckhard. Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation. BMC Dev Biol. 2012;12:28. doi:10.1186/1471-213X-12-28 Ler mais acerca de Distinct patterns of notochord mineralization in zebrafish coincide with the localization of Osteocalcin isoform 1 during early vertebral centra formation. Google Scholar PubMed DOI
2012	Conceição N, Fazenda C, M. Cancela L. Comparative gene promoter analysis: an in silico strategy to identify candidate regulatory factors for Gla Rich Protein. Journal of Applied Ichthyology. 2012;28(3):372 - 376. doi:10.1111/j.1439-0426.2012.02001.x Ler mais acerca de Comparative gene promoter analysis: an in silico strategy to identify candidate regulatory factors for Gla Rich Protein Google Scholar DOI
2012	Bensimon-Brito A, M. Cancela L, Huysseune A, Witten PEckhard. Vestiges, rudiments and fusion events: the zebrafish caudal fin endoskeleton in an evo-devo perspective. Evol Dev. 2012;14(1):116-27. doi:10.1111/j.1525-142X.2011.00526.x Ler mais acerca de Vestiges, rudiments and fusion events: the zebrafish caudal fin endoskeleton in an evo-devo perspective. Google Scholar PubMed DOI
2012	Fazenda C, Silva IAL, M. Cancela L, Conceição N. Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish. Journal of Applied Ichthyology. 2012;28(3):377 - 381. doi:10.1111/j.1439-0426.2012.02004.x Ler mais acerca de Molecular characterization of two paralog genes encoding Gla-rich protein (Grp) in zebrafish Google Scholar DOI
2011	Sousa S, Afonso N, Bensimon-Brito A, et al. Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development. 2011;138(18):3897-905. doi:10.1242/dev.064717 Ler mais acerca de Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Google Scholar PubMed DOI
2011	Tiago DM, Laizé V, Bargelloni L, Ferraresso S, Romualdi C, M. Cancela L. Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate. BMC Genomics. 2011;12:310. doi:10.1186/1471-2164-12-310 Ler mais acerca de Global analysis of gene expression in mineralizing fish vertebra-derived cell lines: new insights into anti-mineralogenic effect of vanadate. Google Scholar PubMed DOI
2011	Tiago DM, M. Cancela L, Laizé V. Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells. J Bone Miner Metab. 2011;29(3):377-82. doi:10.1007/s00774-010-0243-7 Ler mais acerca de Proliferative and mineralogenic effects of insulin, IGF-1, and vanadate in fish osteoblast-like cells. Google Scholar PubMed DOI
2011	Fonseca VG, Rosa J, Laizé V, Gavaia P, M. Cancela L. Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream. Gene Expr Patterns. 2011;11(7):448-55. doi:10.1016/j.gep.2011.07.003 Ler mais acerca de Identification of a new cartilage-specific S100-like protein up-regulated during endo/perichondral mineralization in gilthead seabream. Google Scholar PubMed DOI
2011	Milan M, Coppe A, Reinhardt R, et al. Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring. BMC Genomics. 2011;12:234. doi:10.1186/1471-2164-12-234 Ler mais acerca de Transcriptome sequencing and microarray development for the Manila clam, Ruditapes philippinarum: genomic tools for environmental monitoring. Google Scholar PubMed DOI
2010	Viegas CSB, Conceição N, Fazenda C, Simes DC, M. Cancela L. Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon ( Acipenser naccarii ). Journal of Applied Ichthyology. 2010;26(2):214 - 218. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01408.x Ler mais acerca de Expression of Gla-rich protein (GRP) in newly developed cartilage-derived cell cultures from sturgeon ( Acipenser naccarii ) Google Scholar DOI
2010	Rafael MS, Marques CL, Parameswaran V, M. Cancela L, Laizé V. Fish bone-derived cell lines: an alternative in vitro cell system to study bone biology. Journal of Applied Ichthyology. 2010;26(2):230-234. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01411.x Ler mais acerca de Fish bone-derived cell lines: an alternative in vitro cell system to study bone biology Google Scholar DOI
2010	M. Cancela L, Bargelloni L, Boudry P, et al. Genomic approaches in aquaculture and fisheries. In: J. Cock M, Tessmar-Raible K, Boyen C, Viard F, eds. Introduction To Marine Genomics. Introduction to marine genomics. Dordrecht: Springer Netherlands; 2010:213-286. doi:10.1007/978-90-481-8639-610.1007/978-90-481-8639-6_7 Ler mais acerca de Genomic approaches in aquaculture and fisheries Google Scholar DOI
2010	Simão MF, Leite RB, Rocha C, M. Cancela L. Changes in bioturbation of iron biogeochemistry and in molecular response of the clam Ruditapes decussates upon Perkinsus olseni infection. Arch Environ Contam Toxicol. 2010;59(3):433-43. doi:10.1007/s00244-010-9490-9 Ler mais acerca de Changes in bioturbation of iron biogeochemistry and in molecular response of the clam Ruditapes decussates upon Perkinsus olseni infection. Google Scholar PubMed DOI
2010	Conceição N, Cox CJ, Simões B, Viegas M, M. Cancela L. Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes. Journal of Applied Ichthyology. 2010;26(2):245 - 250. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01415.x Ler mais acerca de Comparative promoter analysis and its application to the identification of candidate regulatory factors of cartilage-expressed genes Google Scholar DOI
2010	Fazenda C, Simões B, Kelsh RN, M. Cancela L, Conceição N. Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis. Gene. 2010;450(1-2):94-102. doi:10.1016/j.gene.2009.10.007 Ler mais acerca de Dual transcriptional regulation by runx2 of matrix Gla protein in Xenopus laevis. Google Scholar PubMed DOI
2010	Louro B, Passos ALúcia, Souche EL, et al. Gilthead sea bream (Sparus auratus) and European sea bass (Dicentrarchus labrax) expressed sequence tags: Characterization, tissue-specific expression and gene markers. Mar Genomics. 2010;3(3-4):179-91. doi:10.1016/j.margen.2010.09.005 Ler mais acerca de Gilthead sea bream (Sparus auratus) and European sea bass (Dicentrarchus labrax) expressed sequence tags: Characterization, tissue-specific expression and gene markers. Google Scholar PubMed DOI
2010	Rosa J, Tiago DM, Dias J, M. Cancela L, Laizé V. Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells. Journal of Applied Ichthyology. 2010;26(2):251 - 256. doi:10.1111/jai.2010.26.issue-210.1111/j.1439-0426.2010.01414.x Ler mais acerca de Serum-specific stimulation of proliferation and mineralization of fish bone-derived cells Google Scholar DOI
2009	Roberto VP, Cavaco S, Viegas CSB, et al. Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation. Aquaculture. 2009;294(3-4):202 - 211. doi:10.1016/j.aquaculture.2009.06.020 Ler mais acerca de Matrix Gla protein in turbot (Scophthalmus maximus): Gene expression analysis and identification of sites of protein accumulation Google Scholar DOI
2009	Laizé V, Tiago DM, Aureliano M, M. Cancela L. New insights into mineralogenic effects of vanadate. Cell Mol Life Sci. 2009;66(24):3831-6. doi:10.1007/s00018-009-0137-9 Ler mais acerca de New insights into mineralogenic effects of vanadate. Google Scholar PubMed DOI
2009	Gavaia P, Domingues S, Engrola S, et al. Comparing skeletal development of wild and hatchery-reared Senegalese sole ( Solea senegalensis , Kaup 1858): evaluation in larval and postlarval stages. Aquaculture Research. 2009;40(14):1585 - 1593. doi:10.1111/are.2009.40.issue-1410.1111/j.1365-2109.2009.02258.x Ler mais acerca de Comparing skeletal development of wild and hatchery-reared Senegalese sole ( Solea senegalensis , Kaup 1858): evaluation in larval and postlarval stages Google Scholar DOI
2009	Viegas CSB, Cavaco S, Neves PL, et al. Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Am J Pathol. 2009;175(6):2288-98. doi:10.2353/ajpath.2009.090474 Ler mais acerca de Gla-rich protein is a novel vitamin K-dependent protein present in serum that accumulates at sites of pathological calcifications. Google Scholar PubMed DOI
2009	Ascenso RMT, Leite RB, Afonso R, M. Cancela L. Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis. J Fish Dis. 2009;32(7):633-6. doi:10.1111/j.1365-2761.2009.01039.x Ler mais acerca de Expression pattern of Perkinsus olseni genes in response to bivalves with different susceptibility to perkinsosis. Google Scholar PubMed DOI
2008	Conceição N, Laizé V, Simões B, Pombinho AR, M. Cancela L. Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata. Biochim Biophys Acta. 2008;1779(1):28-39. doi:10.1016/j.bbagrm.2007.11.003 Ler mais acerca de Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata. Google Scholar PubMed DOI
2008	Tiago DM, M. Cancela L, Aureliano M, Laizé V. Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line. FEBS Lett. 2008;582(9):1381-5. doi:10.1016/j.febslet.2008.03.025 Ler mais acerca de Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line. Google Scholar PubMed DOI
2008	Tiago DM, Laizé V, M. Cancela L. Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development. Gen Comp Endocrinol. 2008;157(2):107-15. doi:10.1016/j.ygcen.2008.04.006 Ler mais acerca de Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development. Google Scholar PubMed DOI
2008	Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, M. Cancela L. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 2008;283(52):36655-64. doi:10.1074/jbc.M802761200 Ler mais acerca de Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. Google Scholar PubMed DOI
2008	Leite RB, Brito AB, M. Cancela L. An oxygen molecular sensor, the HIF prolyl 4-hydroxylase, in the marine protist Perkinsus olseni. Protist. 2008;159(3):355-68. doi:10.1016/j.protis.2008.03.002 Ler mais acerca de An oxygen molecular sensor, the HIF prolyl 4-hydroxylase, in the marine protist Perkinsus olseni. Google Scholar PubMed DOI
2008	Elandalloussi LM, Leite RB, Rodrigues PM, Afonso R, M. Cancela L. Effect of the herbicide Roundup on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus. Bull Environ Contam Toxicol. 2008;80(6):512-5. doi:10.1007/s00128-008-9412-y Ler mais acerca de Effect of the herbicide Roundup on Perkinsus olseni in vitro proliferation and in vivo survival when infecting a permissive host, the clam Ruditapes decussatus. Google Scholar PubMed DOI
2008	Coesel SNicole, Baumgartner ACordeiro, Teles LMarlene, et al. Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress. Mar Biotechnol (NY). 2008;10(5):602-11. doi:10.1007/s10126-008-9100-2 Ler mais acerca de Nutrient limitation is the main regulatory factor for carotenoid accumulation and for Psy and Pds steady state transcript levels in Dunaliella salina (Chlorophyta) exposed to high light and salt stress. Google Scholar PubMed DOI
2008	Tanguy A, Bierne N, Saavedra C, et al. Increasing genomic information in bivalves through new EST collections in four species: development of new genetic markers for environmental studies and genome evolution. Gene. 2008;408(1-2):27-36. doi:10.1016/j.gene.2007.10.021 Ler mais acerca de Increasing genomic information in bivalves through new EST collections in four species: development of new genetic markers for environmental studies and genome evolution. Google Scholar PubMed DOI
2008	Tiago DM, Laizé V, M. Cancela L, Aureliano M. Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line. Cell Biol Toxicol. 2008;24(3):253-63. doi:10.1007/s10565-007-9034-x Ler mais acerca de Impairment of mineralization by metavanadate and decavanadate solutions in a fish bone-derived cell line. Google Scholar PubMed DOI
2007	Pittman K, Rønnestad I, Gavaia P, et al. Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms. Aquaculture Europe . 2007;32(5). Ler mais acerca de Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms Google Scholar
2007	Marques CL, Rafael MS, M. Cancela L, Laizé V. Establishment of primary cell cultures from fish calcified tissues. Cytotechnology. 2007;55(1):9-13. doi:10.1007/s10616-007-9098-8 Ler mais acerca de Establishment of primary cell cultures from fish calcified tissues. Google Scholar PubMed DOI
2007	Brito ABB, M. Cancela L, Gavaia P. Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio). FEBS Journal. 2007;274:265 - 306. doi:10.1111/ejb.2007.274.issue-s110.1111/j.0014-2956.2007.05861_6.x Ler mais acerca de Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio) Google Scholar DOI
2007	Rønnestad I, Gavaia P, Viegas CSB, et al. Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. J Exp Biol. 2007;210(Pt 22):3883-96. doi:10.1242/jeb.007898 Ler mais acerca de Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. Google Scholar PubMed DOI
2007	Kohli V, Robles V, M. Cancela L, Acker JP, Waskiewicz AJ, Elezzabi AY. An alternative method for delivering exogenous material into developing zebrafish embryos. Biotechnol Bioeng. 2007;98(6):1230-41. doi:10.1002/bit.21564 Ler mais acerca de An alternative method for delivering exogenous material into developing zebrafish embryos. Google Scholar PubMed DOI
2007	Fonseca VG, Laizé V, Valente M, M. Cancela L. Identification of an osteopontin-like protein in fish associated with mineral formation. FEBS J. 2007;274(17):4428-39. doi:10.1111/j.1742-4658.2007.05972.x Ler mais acerca de Identification of an osteopontin-like protein in fish associated with mineral formation. Google Scholar PubMed DOI
2007	Robles V, Barbosa V, Herráez MP, Martínez-Páramo S, M. Cancela L. The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures. Theriogenology. 2007;68(2):284-9. doi:10.1016/j.theriogenology.2007.05.003 Ler mais acerca de The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures. Google Scholar PubMed DOI
2006	Simões B, Conceição N, Viegas CSB, et al. Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Calcif Tissue Int. 2006;79(4):230-44. doi:10.1007/s00223-006-0111-6 Ler mais acerca de Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Google Scholar PubMed DOI
2006	Braga D, Laizé V, Tiago DM, M. Cancela L. Enhanced DNA transfer into fish bone cells using polyethylenimine. Molecular Biotechnology. 2006;34(1):51-54. doi:10.1385/MB:34:110.1385/MB:34:1:51 Ler mais acerca de Enhanced DNA transfer into fish bone cells using polyethylenimine Google Scholar DOI
2006	Rafael MS, Laizé V, M. Cancela L. Identification of Sparus aurata bone morphogenetic protein 2: molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates. Bone. 2006;39(6):1373-81. doi:10.1016/j.bone.2006.06.021 Ler mais acerca de Identification of Sparus aurata bone morphogenetic protein 2: molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates. Google Scholar PubMed DOI
2006	Gavaia P, Simes DC, Ortiz-Delgado JB, et al. Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Gene Expr Patterns. 2006;6(6):637-52. doi:10.1016/j.modgep.2005.11.010 Ler mais acerca de Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Google Scholar PubMed DOI
2006	Ortiz-Delgado JB, Simes DC, Viegas CSB, Schaff BJ, Sarasquete C, M. Cancela L. Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal and vascular systems. Histochem Cell Biol. 2006;126(1):89-101. doi:10.1007/s00418-005-0125-6 Ler mais acerca de Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal and vascular systems. Google Scholar PubMed DOI
2006	Laizé V, Viegas CSB, Price PA, M. Cancela L. Identification of an osteocalcin isoform in fish with a large acidic prodomain. Journal of Biological Chemistry. 2006;281(22):15037-15043. doi:10.1074/jbc.M600373200 Ler mais acerca de Identification of an osteocalcin isoform in fish with a large acidic prodomain Google Scholar DOI
2005	Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a New pebp2αA2 Isoform From Zebrafish runx2 Capable of Inducing Osteocalcin Gene Expression In Vitro. Journal of Bone and Mineral Research. 2005;20(8):1440 - 1453. doi:10.1359/JBMR.050318 Ler mais acerca de Identification of a New pebp2αA2 Isoform From Zebrafish runx2 Capable of Inducing Osteocalcin Gene Expression In Vitro Google Scholar DOI
2005	Ortiz-Delgado JB, Simes DC, Gavaia P, Sarasquete C, M. Cancela L. Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution. Histochem Cell Biol. 2005;124(2):123-30. doi:10.1007/s00418-005-0015-y Ler mais acerca de Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution. Google Scholar PubMed DOI
2005	Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. J Bone Miner Res. 2005;20(8):1440-53. doi:10.1359/JBMR.050318 Ler mais acerca de Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. Google Scholar PubMed DOI
2005	Elandalloussi LM, Rodrigues PM, Afonso R, Leite RB, Nunes PA, M. Cancela L. Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni. Mol Biochem Parasitol. 2005;142(1):106-9. doi:10.1016/j.molbiopara.2005.03.014 Ler mais acerca de Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni. Google Scholar PubMed DOI
2005	Engrola S, Conceição LEC, Gavaia P, M. Cancela L, Dinis MTeresa. Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858). Israeli Journal of Aquaculture . 2005;57(1). Ler mais acerca de Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858) Google Scholar
2005	Elworthy S, Pinto JP, Pettifer A, M. Cancela L, Kelsh RN. Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mech Dev. 2005;122(5):659-69. doi:10.1016/j.mod.2004.12.008 Ler mais acerca de Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Google Scholar PubMed DOI
2005	Conceição N, Silva AC, Fidalgo J, Belo JA, M. Cancela L. Identification of alternative promoter usage for the matrix Gla protein gene. Evidence for differential expression during early development in Xenopus laevis. FEBS J. 2005;272(6):1501-10. doi:10.1111/j.1742-4658.2005.04590.x Ler mais acerca de Identification of alternative promoter usage for the matrix Gla protein gene. Evidence for differential expression during early development in Xenopus laevis. Google Scholar PubMed DOI
2005	Frazão C, Simes DC, Coelho R, et al. Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications. Biochemistry. 2005;44(4):1234-42. doi:10.1021/bi048336z Ler mais acerca de Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications. Google Scholar PubMed DOI
2005	Laizé V, Pombinho AR, M. Cancela L. Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: evidence for more than one osteonectin in Salmonidae. Biochimie. 2005;87(5):411-20. doi:10.1016/j.biochi.2005.01.008 Ler mais acerca de Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: evidence for more than one osteonectin in Salmonidae. Google Scholar PubMed DOI
2005	Fonseca VG, Lago-Lestón A, Laizé V, M. Cancela L. Rapid identification of differentially expressed genes by in situ screening of bacteria. Molecular Biotechnology. 2005;30(2):163-166. doi:10.1385/MB:30:210.1385/MB:30:2:163 Ler mais acerca de Rapid identification of differentially expressed genes by in situ screening of bacteria Google Scholar DOI
2005	Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280(29):26659-68. doi:10.1074/jbc.M500257200 Ler mais acerca de Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. Google Scholar PubMed DOI
2005	Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. Journal of Biological Chemistry. 2005;280(29):26659-26668. doi:10.1074/jbc.M500257200 Ler mais acerca de Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates Google Scholar DOI
2004	Elandalloussi LM, Leite RM, Afonso R, et al. Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs. Mol Cell Probes. 2004;18(2):89-96. doi:10.1016/j.mcp.2003.09.008 Ler mais acerca de Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs. Google Scholar PubMed DOI
2004	Simes DC, Williamson MK, Schaff BJ, et al. Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Calcif Tissue Int. 2004;74(2):170-80. doi:10.1007/s00223-003-0079-4 Ler mais acerca de Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Google Scholar PubMed DOI
2004	Pombinho AR, Laizé V, Molha DM, Marques SMP, M. Cancela L. Development of two bone-derived cell lines from the marine teleost Sparus aurata; evidence for extracellular matrix mineralization and cell-type-specific expression of matrix Gla protein and osteocalcin. Cell Tissue Res. 2004;315(3):393-406. doi:10.1007/s00441-003-0830-1 Ler mais acerca de Development of two bone-derived cell lines from the marine teleost Sparus aurata; evidence for extracellular matrix mineralization and cell-type-specific expression of matrix Gla protein and osteocalcin. Google Scholar PubMed DOI
2004	Streiff R, Mira S, Castro M, M. Cancela L. Multiple paternity in Norway lobster (Nephrops norvegicus L.) assessed with microsatellite markers. Mar Biotechnol (NY). 2004;6(1):60-6. doi:10.1007/s10126-003-0015-7 Ler mais acerca de Multiple paternity in Norway lobster (Nephrops norvegicus L.) assessed with microsatellite markers. Google Scholar PubMed DOI
2003	Simes DC, Williamson MK, Ortiz-Delgado JB, Viegas CSB, Price PA, M. Cancela L. Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. J Bone Miner Res. 2003;18(2):244-59. doi:10.1359/jbmr.2003.18.2.244 Ler mais acerca de Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. Google Scholar PubMed DOI
2003	Gavaia P, Ortiz JB, Simes DC, Sarasquete MC, M. Cancela L. SIMULTANEOUS DETECTION OF OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPMENTAL STAGES OF ZEBRA FISH (DANIO RERIO). Calcified Tissue International. 2003;72:314 - 468. doi:10.1007/s00223-003-5002-5 Ler mais acerca de SIMULTANEOUS DETECTION OF OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPMENTAL STAGES OF ZEBRA FISH (DANIO RERIO) Google Scholar DOI
2003	Aurelle D, Guillemaud T, Afonso P, et al. Genetic study of Coris julis (Osteichthyes, Perciformes, Labridae) evolutionary history and dispersal abilities. C R Biol. 2003;326(8):771-85. Ler mais acerca de Genetic study of Coris julis (Osteichthyes, Perciformes, Labridae) evolutionary history and dispersal abilities. Google Scholar PubMed
2003	Elandalloussi LM, Afonso R, Nunes PA, M. Cancela L. Effect of desferrioxamine and 2,2'-bipyridyl on the proliferation of Perkinsus atlanticus. Biomol Eng. 2003;20(4-6):349-54. Ler mais acerca de Effect of desferrioxamine and 2,2'-bipyridyl on the proliferation of Perkinsus atlanticus. Google Scholar PubMed
2003	Pinto JP, Conceição N, Gavaia P, M. Cancela L. Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata. Bone. 2003;32(3):201-10. Ler mais acerca de Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata. Google Scholar PubMed
2002	Robledo JAF, Nunes PA, M. Cancela L, Vasta GR. Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus. J Eukaryot Microbiol. 2002;49(5):414-22. Ler mais acerca de Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus. Google Scholar PubMed
2002	Viegas CSB, Pinto JP, Conceição N, Simes DC, M. Cancela L. Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin. Gene. 2002;289(1-2):97-107. Ler mais acerca de Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin. Google Scholar PubMed
2002	Conceição N, Henriques NM, Ohresser MCP, Hublitz P, Schüle R, M. Cancela L. Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity. Eur J Biochem. 2002;269(7):1947-56. Ler mais acerca de Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity. Google Scholar PubMed
2002	Gavaia P, Dinis MT, M. Cancela L. Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis). Aquaculture. 2002;211(1-4):305 - 323. doi:10.1016/S0044-8486(02)00167-9 Ler mais acerca de Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis) Google Scholar DOI
2001	M. Cancela L, Ohresser MC, Reia JP, Viegas CSB, Williamson MK, Price PA. Matrix Gla protein in Xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations. J Bone Miner Res. 2001;16(9):1611-21. doi:10.1359/jbmr.2001.16.9.1611 Ler mais acerca de Matrix Gla protein in Xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations. Google Scholar PubMed DOI
2001	Pinto JP, Ohresser MC, M. Cancela L. Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man. Gene. 2001;270(1-2):77-91. Ler mais acerca de Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man. Google Scholar PubMed
2001	Gavaia P, Viegas CSB, Pinto JP, Sarasquete MC, M. Cancela L. DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY. Bone. 2001;28:S101 - S248. doi:10.1016/S8756-3282(01)00454-9 Ler mais acerca de DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY Google Scholar DOI
2000	Gavaia P, Sarasquete C, M. Cancela L. Detection of Mineralized Structures in Early Stages of Development of Marine Teleostei Using a Modified Alcian Blue-Alizarin Red Double Staining Technique for Bone and Cartilage. Biotechnic & Histochemistry. 2000;75(2):79 - 84. doi:10.3109/10520290009064151 Ler mais acerca de Detection of Mineralized Structures in Early Stages of Development of Marine Teleostei Using a Modified Alcian Blue-Alizarin Red Double Staining Technique for Bone and Cartilage Google Scholar DOI
2000	Carvalho MC, Streiff R, Guillemaud T, Afonso P, Santos RS, M. Cancela L. Isolation and characterization of polymorphic microsatellite markers in Abudefduf luridus (Pisces: Pomacentridae). Mol Ecol. 2000;9(7):993-4. Ler mais acerca de Isolation and characterization of polymorphic microsatellite markers in Abudefduf luridus (Pisces: Pomacentridae). Google Scholar PubMed
2000	Guillemaud T, Almada F, M. Cancela L. Interspecific Utility of Microsatellites in Fish: A Case Study of (CT)(n) and (GT)(n) Markers in the Shanny Lipophrys pholis (Pisces: Blenniidae) and Their Use in Other Blennioidei. Mar Biotechnol (NY). 2000;2(3):248-253. Ler mais acerca de Interspecific Utility of Microsatellites in Fish: A Case Study of (CT)(n) and (GT)(n) Markers in the Shanny Lipophrys pholis (Pisces: Blenniidae) and Their Use in Other Blennioidei. Google Scholar PubMed
2000	Guillemaud T, Streiff R, R Santos S, Afonso P, Morato T, M. Cancela L. Microsatellite characterization in the rainbow wrasse Coris julis (Pisces: labridae). Mol Ecol. 2000;9(5):631-2. Ler mais acerca de Microsatellite characterization in the rainbow wrasse Coris julis (Pisces: labridae). Google Scholar PubMed
1997	Kirfel J, Kelter M, M. Cancela L, Price PA, Schüle R. Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene. Proc Natl Acad Sci U S A. 1997;94(6):2227-32. Ler mais acerca de Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene. Google Scholar PubMed
1997	M. Cancela L, Hu B, Price PA. Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells. J Cell Physiol. 1997;171(2):125-34. doi:10.1002/(SICI)1097-4652(199705)171:2<125::AID-JCP2>3.0.CO;2-Q Ler mais acerca de Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells. Google Scholar PubMed DOI
1995	M. Cancela L, Williamson MK, Price PA. Amino-acid sequence of bone Gla protein from the African clawed toad Xenopus laevis and the fish Sparus aurata. Int J Pept Protein Res. 1995;46(5):419-23. Ler mais acerca de Amino-acid sequence of bone Gla protein from the African clawed toad Xenopus laevis and the fish Sparus aurata. Google Scholar PubMed
1994	M. Cancela L, Williamson MK, Price PA. The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants. J Biol Chem. 1994;269(16):12185-9. Ler mais acerca de The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants. Google Scholar PubMed
1993	Rannels SR, M. Cancela L, Wolpert EB, Price PA. Matrix Gla protein mRNA expression in cultured type II pneumocytes. Am J Physiol. 1993;265(3 Pt 1):L270-8. Ler mais acerca de Matrix Gla protein mRNA expression in cultured type II pneumocytes. Google Scholar PubMed
1992	M. Cancela L, Price PA. Retinoic acid induces matrix Gla protein gene expression in human cells. Endocrinology. 1992;130(1):102-8. doi:10.1210/endo.130.1.1727694 Ler mais acerca de Retinoic acid induces matrix Gla protein gene expression in human cells. Google Scholar PubMed DOI
1992	M. Cancela L, Ishida H, Bishop JE, Norman AW. Local chromatin changes accompany the expression of the calbindin-D28K gene: tissue specificity and effect of vitamin D activation. Mol Endocrinol. 1992;6(3):468-75. doi:10.1210/mend.6.3.1584219 Ler mais acerca de Local chromatin changes accompany the expression of the calbindin-D28K gene: tissue specificity and effect of vitamin D activation. Google Scholar PubMed DOI
1990	M. Cancela L, Hsieh CL, Francke U, Price PA. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J Biol Chem. 1990;265(25):15040-8. Ler mais acerca de Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. Google Scholar PubMed
1988	Rebut-Bonneton C, Ly SY, M. Cancela L. Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement. Horm Metab Res. 1988;20(6):339-43. doi:10.1055/s-2007-1010831 Ler mais acerca de Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement. Google Scholar PubMed DOI
1988	de Vernejoul MC, Benamout MP, M. Cancela L, et al. [Primary hyperparathyroidism seen in rheumatology. Clinical symptoms and the relation between bone histologic signs and biological parameters]. Rev Rhum Mal Osteoartic. 1988;55(7):489-94. Ler mais acerca de [Primary hyperparathyroidism seen in rheumatology. Clinical symptoms and the relation between bone histologic signs and biological parameters]. Google Scholar PubMed
1988	Minghetti PP, M. Cancela L, Fujisawa Y, Theofan G, Norman AW. Molecular structure of the chicken vitamin D-induced calbindin-D28K gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements. Mol Endocrinol. 1988;2(4):355-67. doi:10.1210/mend-2-4-355 Ler mais acerca de Molecular structure of the chicken vitamin D-induced calbindin-D28K gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements. Google Scholar PubMed DOI
1988	Parisi M, M. Cancela L. Time course studies on phosphate transfer in frog urinary bladder. Kidney Int. 1988;33(1):58-63. Ler mais acerca de Time course studies on phosphate transfer in frog urinary bladder. Google Scholar PubMed
1988	M. Cancela L, Nemere I, Norman AW. 1 alpha,25(OH)2 vitamin D3: a steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms. J Steroid Biochem. 1988;30(1-6):33-9. Ler mais acerca de 1 alpha,25(OH)2 vitamin D3: a steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms. Google Scholar PubMed
1987	M. Cancela L, Rebut-Bonneton C. Regulation of 24-hydroxylase activity in mouse skin fibroblast by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine. J Steroid Biochem. 1987;28(5):479-84. Ler mais acerca de Regulation of 24-hydroxylase activity in mouse skin fibroblast by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine. Google Scholar PubMed
1987	M. Cancela L, Marie PJ, Le Boulch N, Miravet L. Lack of biological activity of vitamin D3-3 beta sulfate during lactation in vitamin D-deficient rats. Reprod Nutr Dev. 1987;27(6):979-97. Ler mais acerca de Lack of biological activity of vitamin D3-3 beta sulfate during lactation in vitamin D-deficient rats. Google Scholar PubMed
1986	Marie PJ, M. Cancela L, Le Boulch N, Miravet L. Bone changes due to pregnancy and lactation: influence of vitamin D status. Am J Physiol. 1986;251(4 Pt 1):E400-6. Ler mais acerca de Bone changes due to pregnancy and lactation: influence of vitamin D status. Google Scholar PubMed
1986	Gruson M, M. Cancela L, Denne MA, Miravet L. Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants. Endocrinol Exp. 1986;20(2-3):329-34. Ler mais acerca de Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants. Google Scholar PubMed
1986	Le Boulch N, M. Cancela L, Miravet L. Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants. Endocrinol Exp. 1986;20(2-3):325-8. Ler mais acerca de Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants. Google Scholar PubMed
1986	M. Cancela L, Le Boulch N, Miravet L. Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants. J Endocrinol. 1986;110(1):43-50. Ler mais acerca de Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants. Google Scholar PubMed
1986	Le Boulch N, M. Cancela L, Miravet L, Lange C. Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry. Biomed Environ Mass Spectrom. 1986;13(2):53-6. Ler mais acerca de Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry. Google Scholar PubMed
1985	M. Cancela L, Marie PJ, Le Boulch N, Miravet L. Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups. J Endocrinol. 1985;105(3):303-9. Ler mais acerca de Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups. Google Scholar PubMed
1985	Rebut-Bonneton C, Demignon J, M. Cancela L, Miravet L. Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat. Reprod Nutr Dev. 1985;25(3):583-90. Ler mais acerca de Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat. Google Scholar PubMed
1985	M. Cancela L, Marie PJ, Le Boulch N, Miravet L. Vitamin D3 3 beta sulfate has less biological activity than free vitamin D3 during pregnancy in rats. Biol Neonate. 1985;48(5):274-84. Ler mais acerca de Vitamin D3 3 beta sulfate has less biological activity than free vitamin D3 during pregnancy in rats. Google Scholar PubMed
1984	M. Cancela L, Le Boulch N, Miravet L. Action of vitamin D3-3 beta-sulfate during lactation in the rat. World Rev Nutr Diet. 1984;43:153-7. Ler mais acerca de Action of vitamin D3-3 beta-sulfate during lactation in the rat. Google Scholar PubMed
1982	Boulch NL, M. Cancela L, Miravet L. Cholecalciferol sulfate identification in human milk by HPLC. Steroids. 1982;39(4):391-8. Ler mais acerca de Cholecalciferol sulfate identification in human milk by HPLC. Google Scholar PubMed
1982	de Vernejoul MC, Girot R, Gueris J, et al. Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia. J Clin Endocrinol Metab. 1982;54(2):276-81. doi:10.1210/jcem-54-2-276 Ler mais acerca de Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia. Google Scholar PubMed DOI