Comparative, Adaptive and Functional Skeletal Biology | - CCMAR -

Comparative, Adaptive and Functional Skeletal Biology

Short Title 
BIOSKEL
Descrição 

Molecular determinants and regulatory mechanisms (transcription and post transcription regulation, alternative and trans-splicing events, RNA editing, epigenetics) affecting gene expression during onset of skeletogenesis and maintenance of bone and cartilage integrity throughout life.
 

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Main interests

Molecular determinants and regulatory mechanisms (transcription and post transcription regulation, alternative and trans-splicing events, RNA editing, epigenetics) affecting gene expression during onset of skeletogenesis and maintenance of bone and cartilage integrity throughout life.

Special interests

Skeleton-associated vitamin K-dependent proteins (osteocalcin, matrix Gla protein, Gla-rich protein/UCMA) known to affect tissue mineralization in normal and pathological conditions, and also involved in cell differentiation, transformation and tissue integrity; Vitamin K metabolism and its recently identified transcription network of target genes and novel functions; Use of fish as models for human diseases with skeletal phenotype.

Others

Molecular evolution of skeletal proteins; Osteo-adaptation and osteotoxicity associated with environmental conditions; Regeneration of calcified tissues; Nutritional requirements associated to normal and pathological skeletal development; Identification of molecules of marine origin with pro/anti-osteogenic properties; Osteo-immunology and musculoskeletal crosstalk.

SEE ALSO THE BIOSKEL WEBPAGE AT http://bioskel.ccmar.ualg.pt

 

 

 

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Coordenador Posição
Leonor Cancela Senior Researcher
Natércia Conceição Investigador
Paulo Jorge Travessa Gavaia Senior Researcher
Vincent Laizé Senior Researcher
Nome Posição
Alessio Carletti PhD Student
Débora Varela PhD Student
Gil Sales Marques Martins PhD Student
Helena Isabel Rosa Pinto Caiado PhD Student
Joana T. Rosa Postdoc
Leonor Cancela Senior Researcher
Márcio Alexandre Filipe Simão PhD Student
Marco Tarasco PhD Student
Natércia Conceição Investigador
Paulo Jorge Travessa Gavaia Senior Researcher
Sunil Poudel PhD Student
Tatiana Varela Investigador
Vânia P. Roberto Postdoc
Vincent Laizé Senior Researcher
Ver em grelha
Retrato de Alessio Carletti
Posição:
PhD Student
Retrato de Débora Varela
Posição:
PhD Student
Retrato de Gil Sales Marques Martins
Posição:
PhD Student
Retrato de Helena Isabel Rosa Pinto Caiado
Posição:
PhD Student
Retrato de Joana T. Rosa
Posição:
Postdoc
Retrato de Leonor Cancela
Posição:
Senior Researcher
Retrato de Márcio Alexandre Filipe Simão
Posição:
PhD Student
Retrato de Marco Tarasco
Posição:
PhD Student
Retrato de Natércia Conceição
Posição:
Investigador
Retrato de Paulo Jorge Travessa Gavaia
Posição:
Senior Researcher
Retrato de Sunil Poudel
Posição:
PhD Student
Retrato de Tatiana Varela
Posição:
Investigador
Retrato de Vânia P. Roberto
Posição:
Postdoc
Retrato de Vincent Laizé
Posição:
Senior Researcher
Antigos Membros
Other Past Members 
António Camacho
Filipe Carvalho
Cátia Marques
Cindy Fazenda
Michael Viegas
Marcelo Livramento
Anabela Bensimon-Brito
Gisela Dionisio
Sara Mira
Marta Rafael
João Fidalgo
Jorge Pinto
Ricardo Afonso
Ricardo Leite
Vijayakumar Parameswaran
Brigite Simões
Joana Rosa
Andreia Adrião
Iris Silva
Marta Vitorino
Mariana Santos
Inês Silva
Vânia Roberto
Luis Granadeiro
Daniel António Martins Tiago
João Cardeira
Tatiana Authier
Patricia Diogo
Ignacio Valentin Fernandez Monzon
Ana Alfaia
Michele Loiodice
Matthew Castaldi
Galeria
Publicações
Todas publicações
Santos JMA, Laizé V, Gavaia PJ, Conceição N, M. Cancela L. Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies. International Journal of Molecular Sciences. 2023;24(4):3366. doi:10.3390/ijms24043366
Soares F, Costas B, Lourenço-Marques C, Fernández I, Gavaia P. Climate Change On Diseases And Disorders Of Finfish In Cage Culture. Chapter 7- Non-Infectious Disorders Of Warmwater Fish. 3rd ed. (Woo PTK, Subasinghe RP, eds.). GB: CABI; 2023:278 - 314. doi:10.1079/9781800621640.0007
Adrião A, Mariano S, Mariano J, et al. mef2ca and mef2cb Double Mutant Zebrafish Show Altered Craniofacial Phenotype and Motor Behaviour. Biomolecules. 2023;13(5):805. doi:10.3390/biom13050805
Berntssen MHG, Fjeldal PG, Gavaia PJ, et al. Dietary beauvericin and enniatin B exposure cause different adverse health effects in farmed Atlantic salmon. Food and Chemical Toxicology. 2023;174:113648. doi:10.1016/j.fct.2023.113648
Dellacqua Z, Di Biagio C, Costa C, et al. Distinguishing the Effects of Water Volumes versus Stocking Densities on the Skeletal Quality during the Pre-Ongrowing Phase of Gilthead Seabream (Sparus aurata). Animals. 2023;13(4):557. doi:10.3390/ani13040557
Diogo P, Martins G, Simão M, et al. Type I Diabetes in Zebrafish Reduces Sperm Quality and Increases Insulin and Glucose Transporter Transcripts. International Journal of Molecular Sciences. 2023;24(8):7035. doi:10.3390/ijms24087035
Carletti A, Rosa JT, Pes K, et al. The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and Molecular Life Sciences. 2023;80(10). doi:10.1007/s00018-023-04953-y
Fernandes JMO, Nedoluzhko AV, Konstantinidis I, Gavaia P. Epigenetics In Fish Growth Chpt. 9. 1st ed. (Piferrer F, Wang H‐P, eds.). Wiley; 2023:209 - 230. doi:10.1002/978111982194610.1002/9781119821946.ch9
Varela D, Varela T, Conceição N, M. Cancela L. Regulation of human ZNF687, a gene associated with Paget's disease of bone. The International Journal of Biochemistry & Cell Biology. 2023;154:106332. doi:10.1016/j.biocel.2022.106332
Varela T, Varela D, Martins G, Conceição N, M. Cancela L. Cdkl5 mutant zebrafish shows skeletal and neuronal alterations mimicking human CDKL5 deficiency disorder. Scientific Reports. 2022;12(1). doi:10.1038/s41598-022-13364-1
Acosta M, Quiroz E, Tovar-Ramírez D, et al. Fish Microbiome Modulation and Convenient Storage of Aquafeeds When Supplemented with Vitamin K1. Animals. 2022;12(23):3248. doi:10.3390/ani12233248
Poudel S, Martins G, M. Cancela L, Gavaia PJ. Regular Supplementation with Antioxidants Rescues Doxorubicin-Induced Bone Deformities and Mineralization Delay in Zebrafish. Nutrients. 2022;14(23):4959. doi:10.3390/nu14234959
Poudel S, Martins G, Cancela LM, Gavaia P. Resveratrol-mediated reversal of Doxorubicin-induced osteoclast differentiation alleviates oxidative stress via FoxM1 expression. Bone Reports. 2022;16:101396. doi:10.1016/j.bonr.2022.101396
Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. Effects of pristine or contaminated polyethylene microplastics on zebrafish development. Chemosphere. 2022;303:135198. doi:10.1016/j.chemosphere.2022.135198
Rosa JT, Tarasco M, Gavaia PJ, M. Cancela L, Laizé V. Screening of Mineralogenic and Osteogenic Compounds in Zebrafish—Tools to Improve Assay Throughput and Data Accuracy. Pharmaceuticals. 2022;15(8):983. doi:10.3390/ph15080983
Cardeira-da-Silva J, Bensimon-Brito A, Tarasco M, et al. Fin ray branching is defined by TRAP+ osteolytic tubules in zebrafish. Proceedings of the National Academy of Sciences. 2022;119(48). doi:10.1073/pnas.2209231119
Poudel S, Izquierdo M, Cancela MLeonor, Gavaia PJ. Reversal of Doxorubicin-Induced Bone Loss and Mineralization by Supplementation of Resveratrol and MitoTEMPO in the Early Development of Sparus aurata. Nutrients. 2022;14(6):1154. doi:10.3390/nu14061154
Laizé V, Rosa JT, Tarasco M, M. Cancela L. Status, challenges, and perspectives of fish cell culture - Focus on cell lines capable of in vitro mineralization. In: Elsevier; 2022:381 - 404. doi:10.1016/B978-0-12-822273-7.00004-5
Sojan JMaria, Gundappa MKumar, Carletti A, et al. Zebrafish as a Model to Unveil the Pro-Osteogenic Effects of Boron-Vitamin D3 Synergism. Frontiers in Nutrition. 2022;9. doi:10.3389/fnut.2022.868805
Adrião A, Santana I, Ribeiro C, M. Cancela L, Conceição N, Grazina M. Identification of a novel mutation in MEF2C gene in an atypical patient with frontotemporal lobar degeneration. Neurological Sciences. 2022;43(1):319 - 326. doi:10.1007/s10072-021-05269-0
Silva IAL, Varela D, M. Cancela L, Conceição N. Zebrafish optineurin: genomic organization and transcription regulation. Genome. 2022;65(10):513 - 523. doi:10.1139/gen-2022-0019
Simão M, Conceição N, Imaginário S, Amaro J, Cancela MLeonor. Lab-it is taking molecular genetics to school. BioChem. 2022;2(2):160 - 170. doi:10.3390/biochem2020011
Pes K, Ortiz-Delgado JB, Sarasquete C, Laizé V, Fernández I. Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: Histological, biochemical and molecular clues for an integrated ecosystem risk assessment. Environmental Toxicology and Pharmacology. 2022;90:103822. doi:10.1016/j.etap.2022.103822
Carletti A, Cardoso C, Lobo-Arteaga J, et al. Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae. Frontiers in Nutrition. 2022;9. doi:10.3389/fnut.2022.888360
Moreira M, Soliño L, Marques CL, et al. Cytotoxic and hemolytic activities of extracts of the fish parasite dinoflagellate Amyloodinium ocellatum. Toxins. 2022;14(7):467. doi:10.3390/toxins14070467
Poudel S, Martins G, M. Cancela L, Gavaia PJ. Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation. International Journal of Molecular Sciences. 2022;23(23):15160. doi:10.3390/ijms232315160
Varela D, Varela T, Conceição N, et al. Functional analysis of two novel TBX5 variants present in individuals with Holt–Oram syndrome with different clinical manifestations. Molecular Genetics and Genomics. 2021;296(4):809 - 821. doi:10.1007/s00438-021-01781-2
Varela D, Conceição N, M. Cancela L. Transcriptional regulation of human T-box 5 gene (TBX5) by bone- and cardiac-related transcription factors. Gene. 2021;768:145322. doi:10.1016/j.gene.2020.145322
Cancela ML, Laizé V, Conceição N, Kempf H, Murshed M. Keutel syndrome, a review of 50 years of literature. Frontiers in Cell and Developmental Biology. 2021;9:642136. doi:10.3389/fcell.2021.642136
Kumar N, Carletti A, Gavaia PJ, et al. Lecture Notes In Computer Science- Computer Analysis Of Images And Patterns: Deep Learning Approaches For Head And Operculum Segmentation In Zebrafish Microscopy Images. Vol. 13052. (Tsapatsoulis N, Panayides A, Theocharides T, Lanitis A, Pattichis C, Vento M, eds.). Cham: Springer International Publishing; 2021:154 - 164. doi:10.1007/978-3-030-89128-2_15
Varela T, Conceição N, Laizé V, Cancela ML. Transcriptional regulation of human DUSP4 gene by cancer‐related transcription factors. Journal of Cellular Biochemistry. 2021;122(10):1556 - 1566. doi:10.1002/jcb.v122.1010.1002/jcb.30078
Roberto VP, Surget G, Le Lann K, et al. Antioxidant, mineralogenic and osteogenic activities of Spartina alterniflora and Salicornia fragilis extracts rich in polyphenols. Frontiers in Nutrition. 2021;8:719438. doi:10.3389/fnut.2021.71943810.3389/fnut.2021.719438.s001
Tarasco M, Gavaia PJ, Bensimon-Brito A, et al. New insights into benzo[⍺]pyrene osteotoxicity in zebrafish. Ecotoxicology and Environmental Safety. 2021;226:112838. doi:10.1016/j.ecoenv.2021.112838
Pes K, Friese A, Cox CJ, Laizé V, Fernández I. Biochemical and molecular responses of the Mediterranean mussel (Mytilus galloprovincialis) to short-term exposure to three commonly prescribed drugs. Marine Environmental Research. 2021;168:105309. doi:10.1016/j.marenvres.2021.105309
Rosa J, Carletti A, Varela T, Gavaia PJ, M. Cancela L, Laizé V. Identification of bone anabolic compounds of marine origin using a zebrafish pipeline. Bone Reports. 2021;14:100985. doi:10.1016/j.bonr.2021.100985
Rosa JT, Laizé V, Gavaia PJ, Cancela ML. Fish models of induced osteoporosis. Frontiers in Cell and Developmental Biology. 2021;9:672424. doi:10.3389/fcell.2021.672424
Poudel S, Izquierdo M, M. Cancela L, Gavaia PJ. Reversal of Doxorubicin-induced bone loss by antioxidant supplement. Bone Reports. 2021;14:100984. doi:10.1016/j.bonr.2021.100984
Caiado H, Conceição N, Tiago D, et al. Evaluation of MGP gene expression in colorectal cancer. Gene. 2020;723:144120. doi:10.1016/j.gene.2019.144120
Caiado H, Conceição N, Tiago D, et al. Data on the evaluation of FGF2 gene expression in Colorectal Cancer. Data in Brief. 2020;31:105765. doi:10.1016/j.dib.2020.105765
Varela T, Laizé V, Conceição N, et al. Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer. Biomarkers in Medicine. 2020;14(8):639 - 650. doi:10.2217/bmm-2019-0369
Martins G, Diogo P, Santos T, et al. Microdiet Formulation with Phospholipid Modulate Zebrafish Skeletal Development and Reproduction. Zebrafish. 2020. doi:10.1089/zeb.2019.1794
Beato S, Marques C, Laizé V, Gavaia PJ, Fernández I. New Insights on Vitamin K Metabolism in Senegalese sole (Solea senegalensis) Based on Ontogenetic and Tissue-Specific Vitamin K Epoxide Reductase Molecular Data. International Journal of Molecular Sciences. 2020;21(10):3489. doi:10.3390/ijms21103489
Viegas MN, Salgado MAntonia, Aguiar C, Almeida A, Gavaia P, Dias J. Effect of Dietary Manganese and Zinc Levels on Growth and Bone Status of Senegalese Sole (Solea senegalensis) Post-Larvae. Biological Trace Element Research. 2020. doi:10.1007/s12011-020-02307-4
Vijayakumar P, Cardeira J, Laizé V, Gavaia PJ, M. Cancela L. Cells Isolated from Regenerating Caudal Fin of Sparus aurata Can Differentiate into Distinct Bone Cell Lineages. Marine Biotechnology. 2020;22(3):333 - 347. doi:10.1007/s10126-019-09937-3
Carletti A, Cardoso C, Juliao D, et al. Biopotential of Sea Cucumbers (Echinodermata) and Tunicates (Chordata) from the Western Coast of Portugal for the Prevention and Treatment of Chronic Illnesses. Proceedings. 2020;61(1):13. doi:10.3390/IECN2020-06994
Viegas MN, Laizé V, Salgado MA, Aguiar C, Dias J. Effect of Trace Minerals and B Vitamins on the Proliferation/Cytotoxicity and Mineralization of a Gilthead Seabream Bone–Derived Cell Line. Biological Trace Element Research. 2020;196(2):629 - 638. doi:10.1007/s12011-019-01939-5
Vijayakumar P, M. Cancela L, Laizé V. Isolation, Culture, and Differentiation of Blastema Cells from the Regenerating Caudal Fin of Zebrafish. Fishes. 2020;5(1):6. doi:10.3390/fishes5010006
Tarasco M, Martins G, Gavaia PJ, Bebianno MJ, M. Cancela L, Laizé V. ZEB316: A Small Stand-Alone Housing System to Study Microplastics in Small Teleosts. Zebrafish. 2020;17(1):18-26. doi:10.1089/zeb.2019.1801
Tarasco M, Cordelières FP, M. Cancela L, Laizé V. ZFBONE: An ImageJ toolset for semi-automatic analysis of zebrafish bone structures. Bone. 2020;138:115480. doi:10.1016/j.bone.2020.115480
Bäck M, Aranyi T, M. Cancela L, et al. Endogenous Calcification Inhibitors in the Prevention of Vascular Calcification: A Consensus Statement From the COST Action EuroSoftCalcNet. Frontiers in Cardiovascular Medicine. 2019;5. doi:10.3389/fcvm.2018.00196
Diogo P, Martins G, Eufrásio A, Silva T, Cabrita E, Gavaia P. Selection Criteria of Zebrafish Male Donors for Sperm Cryopreservation. Zebrafish. 2019;16(2):189-196. doi:10.1089/zeb.2018.1660
Martins G, Diogo P, Pinto W, Gavaia PJ. Early Transition to Microdiets Improves Growth, Reproductive Performance and Reduces Skeletal Anomalies in Zebrafish ( Danio rerio ). Zebrafish. 2019;16(3):300-307. doi:10.1089/zeb.2018.1691
Carson MA, Nelson J, M. Cancela L, et al. Correction: Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. PLOS ONE. 2019;14(1):e0211395. doi:10.1371/journal.pone.0211395
Santos JMA, Mendes-Silva L, Afonso V, et al. Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants. Cell Death & Disease. 2019;10(8). doi:10.1038/s41419-019-1816-6
Martins G, Ribeiro L, Candeias‐Mendes A, et al. Reduction of skeletal anomalies in meagre ( Argyrosomus regius , Asso, 1801) through early introduction of inert diet. Aquaculture Research. 2019;50(10):2782 - 2792. doi:10.1111/are.v50.1010.1111/are.14230
Simão M, Gavaia PJ, Camacho A, et al. Intracellular iron uptake is favored in Hfe ‐KO mouse primary chondrocytes mimicking an osteoarthritis‐related phenotype. BioFactors. 2019. doi:10.1002/biof.1520
Navarro-Guillén C, Dias J, Rocha F, et al. Does a ghrelin stimulus during zebrafish embryonic stage modulate its performance on the long-term?. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 2019;228:1 - 8. doi:10.1016/j.cbpa.2018.10.019
Diogo P, Martins G, Nogueira R, Marreiros A, Gavaia PJ, Cabrita E. Cryoprotectants synergy improve zebrafish sperm cryopreservation and offspring skeletogenesis. Cryobiology. 2019. doi:10.1016/j.cryobiol.2019.10.001
Granadeiro L, Dirks RP, Ortiz-Delgado JB, et al. Warfarin-exposed zebrafish embryos resembles human warfarin embryopathy in a dose and developmental-time dependent manner – From molecular mechanisms to environmental concerns. Ecotoxicology and Environmental Safety. 2019;181:559 - 571. doi:10.1016/j.ecoenv.2019.06.042
Fernández I, Fernandes JMO, Roberto VP, et al. Circulating small non-coding RNAs provide new insights into vitamin K nutrition and reproductive physiology in teleost fish. Biochimica et Biophysica Acta (BBA) - General Subjects. 2019;1863(1):39-51. doi:10.1016/j.bbagen.2018.09.017
Oralová V, Rosa JT, Soenens M, et al. Beyond the whole-mount phenotype: high-resolution imaging in fluorescence-based applications on zebrafish. Biology Open. 2019;8(5):bio042374. doi:10.1242/bio.042374
Carvalho FR, Calado SM, Silva GA, et al. Altered bone microarchitecture in a type 1 diabetes mouse model Ins2 Akita . Journal of Cellular Physiology. 2019;234(6):9338-9350 . doi:10.1002/jcp.27617
Rosa JT, Oralová V, Larionova D, Eisenhoffer GT, P. Witten E, Huysseune A. Periderm invasion contributes to epithelial formation in the teleost pharynx. Scientific Reports. 2019;9(1). doi:10.1038/s41598-019-46040-y
Tarasco M, Cardeira J, Viegas M, et al. Anti-osteogenic activity of cadmium in zebrafish. Fishes. 2019;4(1):11. doi:10.3390/fishes4010011
Fazenda C, Martins G, Gavaia P, M. Cancela L, Conceição N. Generation of zebrafish Danio rerio (Hamilton, 1822) transgenic lines overexpressing a heat-shock mediated Gla-rich protein. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13662
Cardeira J, Laizé V, Martins G, M. Cancela L, Gavaia P. An overview on the teleost bone mechanophysiology. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13661
Ferreira-Rodríguez N, Fernández I, M. Cancela L, Pardo I. Multibiomarker response shows how native and non-native freshwater bivalves differentially cope with heat-wave events. Aquatic Conservation: Marine and Freshwater Ecosystems. 2018. doi:10.1002/aqc.2884
Diogo P, Martins G, Quinzico I, Nogueira R, Gavaia P, Cabrita E. Electric ultrafreezer (− 150 °C) as an alternative for zebrafish sperm cryopreservation and storage. Fish Physiology and Biochemistry. 2018. doi:10.1007/s10695-018-0500-6
Carson MA, Nelson J, M. Cancela L, et al. Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-26024-0
Laizé V, Gavaia P, Tarasco M, et al. Osteotoxicity of 3-methylcholanthrene in fish. Ecotoxicology and Environmental Safety. 2018;161:721 - 728. doi:10.1016/j.ecoenv.2018.06.035
Carson MA, Nelson J, M. Cancela L, et al. Screening for osteogenic activity in extracts from Irish marine organisms: The potential of Ceramium pallidum. Cray JJ, ed. PLOS ONE. 2018;13(11):e0207303. doi:10.1371/journal.pone.0207303.s008
Silva IAL, Conceição N, Gagnon E, Brown JP, M. Cancela L, Michou L. Molecular effect of an OPTN common variant associated to Paget's disease of bone. PLOS ONE. 2018;13(5):e0197543. doi:10.1371/journal.pone.0197543.s007
Vitorino M, Cunha N, Conceição N, M. Cancela L. Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome. Molecular Biology Reports. 2018. doi:10.1007/s11033-018-4180-1
Vitorino M, Conceição N, M. Cancela L. Zebrafish (Danio rerio, Hamilton-Buchanan, 1822) as a model to study bone diseases associated with Rett syndrome. Journal of Applied Ichthyology. 2018;34(2):489 - 500. doi:10.1111/jai.13667
Fernández I, Gavaia P, Laizé V, M. Cancela L. Fish as a model to assess chemical toxicity in bone. Aquatic Toxicology. 2018;194:208 - 226. doi:10.1016/j.aquatox.2017.11.015
Silva IAL, Conceição N, Gagnon E, et al. Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018;1864(1):143 - 151. doi:10.1016/j.bbadis.2017.10.008
Fernandez I, Gavaia P, Darias M, Gisbert E. Fat-soluble vitamins in fish: A transcriptional tissue-specific crosstalk that remains to be unveiled and characterized. In: Emerging Issues In Fish Larvae Research. Emerging issues in fish larvae research. Springer International Publishing AG; 2018.
Fernández I, Granadeiro L, Darias MJ, Gavaia P, Andree KB, Gisbert E. Solea senegalensis skeletal ossification and gene expression patterns during metamorphosis: New clues on the onset of skeletal deformities during larval to juvenile transition. Aquaculture. 2018;496:153 - 165. doi:10.1016/j.aquaculture.2018.07.022
Gonçalves R, Tarasco M, Schatzmayr D, Gavaia P. Preliminary Evaluation of Moniliformin as a Potential Threat for Teleosts. Fishes. 2018;3(1):4. doi:10.3390/fishes3010004
Rosa J, Cox CJ, M. Cancela L, Laizé V. Identification of a fish short-chain dehydrogenase/reductase associated with bone metabolism. Gene. 2018;645:137 - 145. doi:10.1016/j.gene.2017.12.021
Soares F, Roque A, Gavaia P. Review of the principal diseases affecting cultured meagre ( Argyrosomus regius). Aquaculture Research. 2018. doi:10.1111/are.13613
Roberto VP, Gavaia P, Nunes MJ, Rodrigues E, M. Cancela L, Tiago DM. Evidences for a New Role of miR-214 in Chondrogenesis. Scientific Reports. 2018;8(1). doi:10.1038/s41598-018-21735-w
Roberto VP, Martins G, Pereira A, et al. Insights from dietary supplementation with zinc and strontium on the skeleton of zebrafish, Danio rerio (Hamilton, 1822) larvae: From morphological analysis to osteogenic markers. Journal of Applied Ichthyology. 2018. doi:10.1111/jai.13664
Carvalho FR, Fernandes AR, M. Cancela L, Gavaia P. Improved regeneration and de novo bone formation in a diabetic zebrafish model treated with Paricalcitol and Cinacalcet. Wound Repair and Regeneration. 2017;86(6):1796–1810. doi:10.1111/wrr.12536
Tarasco M, Laizé V, Cardeira J, M. Cancela L, Gavaia P. The zebrafish operculum: A powerful system to assess osteogenic bioactivities of molecules with pharmacological and toxicological relevance. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2017;197:45 - 52. doi:10.1016/j.cbpc.2017.04.006
Marques C, Roberto VP, Granadeiro L, et al. The xenobiotic sensor PXR in a marine flatfish species ( Solea senegalensis ): Gene expression patterns and its regulation under different physiological conditions. Marine Environmental Research. 2017;130:187-199. doi:10.1016/j.marenvres.2017.07.021
Boglione C, Gavaia P, Koumoundouros G, et al. Skeletal Anomalies in Reared European Fish Larvae and Juveniles. Part 1: Normal and Anomalous Skeletogenic Processes. In: Conceição LEC, Tandler A, eds. Success Factors For Fish Larval Production. Success Factors for Fish Larval Production. Wiley; 2017:219-254. https://books.google.pt/books?id=xV_HrQEACAAJ.
Boglione C, Gisbert E, Gavaia P, et al. Skeletal Anomalies in Reared European Fish Larvae and Juveniles. Part 2:Main Typologies, Occurrences and Causative Factors. In: Conceição LEC, Tandler A, eds. Success Factors For Fish Larval Production. Success Factors for Fish Larval Production. Wiley; 2017:255-330. https://books.google.pt/books?id=xV_HrQEACAAJ.
Riesco MF, Oliveira C, Soares F, Gavaia P, Dinis MT, Cabrita E. Solea senegalensis sperm cryopreservation: New insights on sperm quality. Prunet P, ed. PLOS ONE. 2017;12(10):e0186542. doi:10.1371/journal.pone.0186542.s003
Surget G, Roberto VP, Le Lann K, et al. Marine green macroalgae: a source of natural compounds with mineralogenic and antioxidant activities. Journal of Applied Phycology. 2017;29:575-584. doi:10.1007/s10811-016-0968-3
Medeiros MCR, Mestre A, Inácio P, et al. An electrical method to measure low-frequency collective and synchronized cell activity using extracellular electrodes. Sensing and Bio-Sensing Research. 2016;10:1 - 8. doi:10.1016/j.sbsr.2016.06.002
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Fernández I, Vijayakumar P, Marques C, M. Cancela L, Gavaia P, Laizé V. Zebrafish vitamin K epoxide reductases: expression in vivo, along extracellular matrix mineralization and under phylloquinone and warfarin in vitro exposure. Fish Physiology and Biochemistry. 2015;41(3):745-759. doi:10.1007/s10695-015-0043-z
Rodrigues ET, Pardal MÂ, Laizé V, M. Cancela L, Oliveira PJ, Serafim TL. Cardiomyocyte H9c2 cells present a valuable alternative to fish lethal testing for azoxystrobin. Environ Pollut. 2015;206:619-26. doi:10.1016/j.envpol.2015.08.026
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Marques CL, Fernández I, Rosa J, Viegas MN, M. Cancela L, Laizé V. Spatiotemporal expression and retinoic acid regulation of bone morphogenetic proteins 2, 4 and 16 in Senegalese sole. Journal of Applied Ichthyology. 2014;30(4):713-720. doi:10.1111/jai.2014.30.issue-410.1111/jai.12539
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Conceição N, Laizé V, Simões B, Pombinho AR, M. Cancela L. Retinoic acid is a negative regulator of matrix Gla protein gene expression in teleost fish Sparus aurata. Biochim Biophys Acta. 2008;1779(1):28-39. doi:10.1016/j.bbagrm.2007.11.003
Tiago DM, M. Cancela L, Aureliano M, Laizé V. Vanadate proliferative and anti-mineralogenic effects are mediated by MAPK and PI-3K/Ras/Erk pathways in a fish chondrocyte cell line. FEBS Lett. 2008;582(9):1381-5. doi:10.1016/j.febslet.2008.03.025
Tiago DM, Laizé V, M. Cancela L. Alternatively spliced transcripts of Sparus aurata insulin-like growth factor 1 are differentially expressed in adult tissues and during early development. Gen Comp Endocrinol. 2008;157(2):107-15. doi:10.1016/j.ygcen.2008.04.006
Viegas CSB, Simes DC, Laizé V, Williamson MK, Price PA, M. Cancela L. Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates. J Biol Chem. 2008;283(52):36655-64. doi:10.1074/jbc.M802761200
Brito ABB, M. Cancela L, Gavaia P. Expression of osteonectin correlates with levels of fin regeneration in zebrafish (Danio rerio). FEBS Journal. 2007;274:265 - 306. doi:10.1111/ejb.2007.274.issue-s110.1111/j.0014-2956.2007.05861_6.x
Stefanni S, Porteiro FM, Bettencourt R, Gavaia P, Santos RS. Molecular insights indicate that Pachycara thermophilum (Geistdoerfer, 1994) and P. saldanhai (Biscoito and Almeida, 2004) (Perciformes: Zoarcidae) from the Mid-Atlantic Ridge are synonymous species. Molecular Phylogenetics and Evolution. 2007;45(1):423 - 426. doi:10.1016/j.ympev.2007.02.001
Marques CL, Rafael MS, M. Cancela L, Laizé V. Establishment of primary cell cultures from fish calcified tissues. Cytotechnology. 2007;55(1):9-13. doi:10.1007/s10616-007-9098-8
Rønnestad I, Gavaia P, Viegas CSB, et al. Oligopeptide transporter PepT1 in Atlantic cod (Gadus morhua L.): cloning, tissue expression and comparative aspects. J Exp Biol. 2007;210(Pt 22):3883-96. doi:10.1242/jeb.007898
Stefanni S, Porteiro FM, Bettencourt R, Gavaia P, Santos RS. Molecular insights indicate that Pachycara thermophilum () and P. saldanhai () (Perciformes: Zoarcidae) from the Mid-Atlantic Ridge are synonymous species. Mol Phylogenet Evol. 2007;45(1):423-6. doi:10.1016/j.ympev.2007.02.001
Kohli V, Robles V, M. Cancela L, Acker JP, Waskiewicz AJ, Elezzabi AY. An alternative method for delivering exogenous material into developing zebrafish embryos. Biotechnol Bioeng. 2007;98(6):1230-41. doi:10.1002/bit.21564
Fonseca VG, Laizé V, Valente M, M. Cancela L. Identification of an osteopontin-like protein in fish associated with mineral formation. FEBS J. 2007;274(17):4428-39. doi:10.1111/j.1742-4658.2007.05972.x
Robles V, Barbosa V, Herráez MP, Martínez-Páramo S, M. Cancela L. The antifreeze protein type I (AFP I) increases seabream (Sparus aurata) embryos tolerance to low temperatures. Theriogenology. 2007;68(2):284-9. doi:10.1016/j.theriogenology.2007.05.003
Pittman K, Rønnestad I, Gavaia P, et al. Fish Larval Research: a tool for sustainable food production and understanding environmental impacts on developing organisms. Aquaculture Europe . 2007;32(5).
Laizé V, Viegas CSB, Price PA, M. Cancela L. Identification of an osteocalcin isoform in fish with a large acidic prodomain. Journal of Biological Chemistry. 2006;281(22):15037-15043. doi:10.1074/jbc.M600373200
Braga D, Laizé V, Tiago DM, M. Cancela L. Enhanced DNA transfer into fish bone cells using polyethylenimine. Molecular Biotechnology. 2006;34(1):51-54. doi:10.1385/MB:34:110.1385/MB:34:1:51
Simões B, Conceição N, Viegas CSB, et al. Identification of a promoter element within the zebrafish colXalpha1 gene responsive to runx2 isoforms Osf2/Cbfa1 and til-1 but not to pebp2alphaA2. Calcif Tissue Int. 2006;79(4):230-44. doi:10.1007/s00223-006-0111-6
Rafael MS, Laizé V, M. Cancela L. Identification of Sparus aurata bone morphogenetic protein 2: molecular cloning, gene expression and in silico analysis of protein conserved features in vertebrates. Bone. 2006;39(6):1373-81. doi:10.1016/j.bone.2006.06.021
Gavaia P, Simes DC, Ortiz-Delgado JB, et al. Osteocalcin and matrix Gla protein in zebrafish (Danio rerio) and Senegal sole (Solea senegalensis): comparative gene and protein expression during larval development through adulthood. Gene Expr Patterns. 2006;6(6):637-52. doi:10.1016/j.modgep.2005.11.010
Ortiz-Delgado JB, Simes DC, Viegas CSB, Schaff BJ, Sarasquete C, M. Cancela L. Cloning of matrix Gla protein in a marine cartilaginous fish, Prionace glauca: preferential protein accumulation in skeletal and vascular systems. Histochem Cell Biol. 2006;126(1):89-101. doi:10.1007/s00418-005-0125-6
Elandalloussi LM, Rodrigues PM, Afonso R, Leite RB, Nunes PA, M. Cancela L. Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni. Mol Biochem Parasitol. 2005;142(1):106-9. doi:10.1016/j.molbiopara.2005.03.014
Elworthy S, Pinto JP, Pettifer A, M. Cancela L, Kelsh RN. Phox2b function in the enteric nervous system is conserved in zebrafish and is sox10-dependent. Mech Dev. 2005;122(5):659-69. doi:10.1016/j.mod.2004.12.008
Conceição N, Silva AC, Fidalgo J, Belo JA, M. Cancela L. Identification of alternative promoter usage for the matrix Gla protein gene. Evidence for differential expression during early development in Xenopus laevis. FEBS J. 2005;272(6):1501-10. doi:10.1111/j.1742-4658.2005.04590.x
Fonseca VG, Lago-Lestón A, Laizé V, M. Cancela L. Rapid identification of differentially expressed genes by in situ screening of bacteria. Molecular Biotechnology. 2005;30(2):163-166. doi:10.1385/MB:30:210.1385/MB:30:2:163
Frazão C, Simes DC, Coelho R, et al. Structural evidence of a fourth Gla residue in fish osteocalcin: biological implications. Biochemistry. 2005;44(4):1234-42. doi:10.1021/bi048336z
Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone  gamma-carboxyglutamic acid proteins in vertebrates. Journal of Biological Chemistry. 2005;280(29):26659-26668. doi:10.1074/jbc.M500257200
Laizé V, Pombinho AR, M. Cancela L. Characterization of Sparus aurata osteonectin cDNA and in silico analysis of protein conserved features: evidence for more than one osteonectin in Salmonidae. Biochimie. 2005;87(5):411-20. doi:10.1016/j.biochi.2005.01.008
Laizé V, Martel P, Viegas CSB, Price PA, M. Cancela L. Evolution of matrix and bone gamma-carboxyglutamic acid proteins in vertebrates. J Biol Chem. 2005;280(29):26659-68. doi:10.1074/jbc.M500257200
Engrola S, Conceição LEC, Gavaia P, M. Cancela L, Dinis MTeresa. Effect of pre-weaning feeding regime on weaning performance of Senegalese sole, Solea senegalensis (Kaup, 1858). Israeli Journal of Aquaculture . 2005;57(1).
Ortiz-Delgado JB, Simes DC, Gavaia P, Sarasquete C, M. Cancela L. Osteocalcin and matrix GLA protein in developing teleost teeth: identification of sites of mRNA and protein accumulation at single cell resolution. Histochem Cell Biol. 2005;124(2):123-30. doi:10.1007/s00418-005-0015-y
Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro. J Bone Miner Res. 2005;20(8):1440-53. doi:10.1359/JBMR.050318
Pinto JP, Conceição NM, Viegas CSB, et al. Identification of a New pebp2αA2 Isoform From Zebrafish runx2 Capable of Inducing Osteocalcin Gene Expression In Vitro. Journal of Bone and Mineral Research. 2005;20(8):1440 - 1453. doi:10.1359/JBMR.050318
Elandalloussi LM, Leite RM, Afonso R, et al. Development of a PCR-ELISA assay for diagnosis of Perkinsus marinus and Perkinsus atlanticus infections in bivalve molluscs. Mol Cell Probes. 2004;18(2):89-96. doi:10.1016/j.mcp.2003.09.008
Pombinho AR, Laizé V, Molha DM, Marques SMP, M. Cancela L. Development of two bone-derived cell lines from the marine teleost Sparus aurata; evidence for extracellular matrix mineralization and cell-type-specific expression of matrix Gla protein and osteocalcin. Cell Tissue Res. 2004;315(3):393-406. doi:10.1007/s00441-003-0830-1
Simes DC, Williamson MK, Schaff BJ, et al. Characterization of osteocalcin (BGP) and matrix Gla protein (MGP) fish specific antibodies: validation for immunodetection studies in lower vertebrates. Calcif Tissue Int. 2004;74(2):170-80. doi:10.1007/s00223-003-0079-4
Streiff R, Mira S, Castro M, M. Cancela L. Multiple paternity in Norway lobster (Nephrops norvegicus L.) assessed with microsatellite markers. Mar Biotechnol (NY). 2004;6(1):60-6. doi:10.1007/s10126-003-0015-7
Gavaia P, Ortiz JB, Simes DC, Sarasquete MC, M. Cancela L. SIMULTANEOUS DETECTION OF OSTEOCALCIN AND MATRIX GLA PROTEIN IN DEVELOPMENTAL STAGES OF ZEBRA FISH (DANIO RERIO). Calcified Tissue International. 2003;72:314 - 468. doi:10.1007/s00223-003-5002-5
Aurelle D, Guillemaud T, Afonso P, et al. Genetic study of Coris julis (Osteichthyes, Perciformes, Labridae) evolutionary history and dispersal abilities. C R Biol. 2003;326(8):771-85.
Elandalloussi LM, Afonso R, Nunes PA, M. Cancela L. Effect of desferrioxamine and 2,2'-bipyridyl on the proliferation of Perkinsus atlanticus. Biomol Eng. 2003;20(4-6):349-54.
Pinto JP, Conceição N, Gavaia P, M. Cancela L. Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata. Bone. 2003;32(3):201-10.
Simes DC, Williamson MK, Ortiz-Delgado JB, Viegas CSB, Price PA, M. Cancela L. Purification of matrix Gla protein from a marine teleost fish, Argyrosomus regius: calcified cartilage and not bone as the primary site of MGP accumulation in fish. J Bone Miner Res. 2003;18(2):244-59. doi:10.1359/jbmr.2003.18.2.244
Gavaia P, Dinis MT, M. Cancela L. Osteological development and abnormalities of the vertebral column and caudal skeleton in larval and juvenile stages of hatchery-reared Senegal sole (Solea senegalensis). Aquaculture. 2002;211(1-4):305 - 323. doi:10.1016/S0044-8486(02)00167-9
Robledo JAF, Nunes PA, M. Cancela L, Vasta GR. Development of an in vitro clonal culture and characterization of the rRNA gene cluster of Perkinsus atlanticus, a protistan parasite of the clam Tapes decussatus. J Eukaryot Microbiol. 2002;49(5):414-22.
Viegas CSB, Pinto JP, Conceição N, Simes DC, M. Cancela L. Cloning and characterization of the cDNA and gene encoding Xenopus laevis osteocalcin. Gene. 2002;289(1-2):97-107.
Conceição N, Henriques NM, Ohresser MCP, Hublitz P, Schüle R, M. Cancela L. Molecular cloning of the Matrix Gla Protein gene from Xenopus laevis. Functional analysis of the promoter identifies a calcium sensitive region required for basal activity. Eur J Biochem. 2002;269(7):1947-56.
Gavaia P, Viegas CSB, Pinto JP, Sarasquete MC, M. Cancela L. DETECTION AND LOCALIZATION OF OSTEOCALCIN (BGP OR BONE GLA PROTEIN) IN TELEOSTS BY IN SITU HYBRIDATION AND IMMUNOHISTOCHEMISTRY. Bone. 2001;28:S101 - S248. doi:10.1016/S8756-3282(01)00454-9
M. Cancela L, Ohresser MC, Reia JP, Viegas CSB, Williamson MK, Price PA. Matrix Gla protein in Xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations. J Bone Miner Res. 2001;16(9):1611-21. doi:10.1359/jbmr.2001.16.9.1611
Pinto JP, Ohresser MC, M. Cancela L. Cloning of the bone Gla protein gene from the teleost fish Sparus aurata. Evidence for overall conservation in gene organization and bone-specific expression from fish to man. Gene. 2001;270(1-2):77-91.
Carvalho MC, Streiff R, Guillemaud T, Afonso P, Santos RS, M. Cancela L. Isolation and characterization of polymorphic microsatellite markers in Abudefduf luridus (Pisces: Pomacentridae). Mol Ecol. 2000;9(7):993-4.
Guillemaud T, Almada F, M. Cancela L. Interspecific Utility of Microsatellites in Fish: A Case Study of (CT)(n) and (GT)(n) Markers in the Shanny Lipophrys pholis (Pisces: Blenniidae) and Their Use in Other Blennioidei. Mar Biotechnol (NY). 2000;2(3):248-253.
Gavaia P, Sarasquete C, M. Cancela L. Detection of Mineralized Structures in Early Stages of Development of Marine Teleostei Using a Modified Alcian Blue-Alizarin Red Double Staining Technique for Bone and Cartilage. Biotechnic & Histochemistry. 2000;75(2):79 - 84. doi:10.3109/10520290009064151
Guillemaud T, Streiff R, R Santos S, Afonso P, Morato T, M. Cancela L. Microsatellite characterization in the rainbow wrasse Coris julis (Pisces: labridae). Mol Ecol. 2000;9(5):631-2.
M. Cancela L, Hu B, Price PA. Effect of cell density and growth factors on matrix GLA protein expression by normal rat kidney cells. J Cell Physiol. 1997;171(2):125-34. doi:10.1002/(SICI)1097-4652(199705)171:2<125::AID-JCP2>3.0.CO;2-Q
Kirfel J, Kelter M, M. Cancela L, Price PA, Schüle R. Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene. Proc Natl Acad Sci U S A. 1997;94(6):2227-32.
M. Cancela L, Williamson MK, Price PA. Amino-acid sequence of bone Gla protein from the African clawed toad Xenopus laevis and the fish Sparus aurata. Int J Pept Protein Res. 1995;46(5):419-23.
M. Cancela L, Williamson MK, Price PA. The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants. J Biol Chem. 1994;269(16):12185-9.
Rannels SR, M. Cancela L, Wolpert EB, Price PA. Matrix Gla protein mRNA expression in cultured type II pneumocytes. Am J Physiol. 1993;265(3 Pt 1):L270-8.
M. Cancela L, Price PA. Retinoic acid induces matrix Gla protein gene expression in human cells. Endocrinology. 1992;130(1):102-8. doi:10.1210/endo.130.1.1727694
M. Cancela L, Ishida H, Bishop JE, Norman AW. Local chromatin changes accompany the expression of the calbindin-D28K gene: tissue specificity and effect of vitamin D activation. Mol Endocrinol. 1992;6(3):468-75. doi:10.1210/mend.6.3.1584219
M. Cancela L, Hsieh CL, Francke U, Price PA. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J Biol Chem. 1990;265(25):15040-8.
Parisi M, M. Cancela L. Time course studies on phosphate transfer in frog urinary bladder. Kidney Int. 1988;33(1):58-63.
M. Cancela L, Nemere I, Norman AW. 1 alpha,25(OH)2 vitamin D3: a steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms. J Steroid Biochem. 1988;30(1-6):33-9.
Rebut-Bonneton C, Ly SY, M. Cancela L. Calcium-transport in quiescent and 1,25-dihydroxycholecalciferol-stimulated human osteosarcoma cells. Role in 24 hydroxylase enhancement. Horm Metab Res. 1988;20(6):339-43. doi:10.1055/s-2007-1010831
de Vernejoul MC, Benamout MP, M. Cancela L, et al. [Primary hyperparathyroidism seen in rheumatology. Clinical symptoms and the relation between bone histologic signs and biological parameters]. Rev Rhum Mal Osteoartic. 1988;55(7):489-94.
Minghetti PP, M. Cancela L, Fujisawa Y, Theofan G, Norman AW. Molecular structure of the chicken vitamin D-induced calbindin-D28K gene reveals eleven exons, six Ca2+-binding domains, and numerous promoter regulatory elements. Mol Endocrinol. 1988;2(4):355-67. doi:10.1210/mend-2-4-355
M. Cancela L, Rebut-Bonneton C. Regulation of 24-hydroxylase activity in mouse skin fibroblast by cholecalciferol derivatives, triamcinolone acetonide and a calcium modulating agent, nicardipine. J Steroid Biochem. 1987;28(5):479-84.
M. Cancela L, Marie PJ, Le Boulch N, Miravet L. Lack of biological activity of vitamin D3-3 beta sulfate during lactation in vitamin D-deficient rats. Reprod Nutr Dev. 1987;27(6):979-97.
Marie PJ, M. Cancela L, Le Boulch N, Miravet L. Bone changes due to pregnancy and lactation: influence of vitamin D status. Am J Physiol. 1986;251(4 Pt 1):E400-6.
Gruson M, M. Cancela L, Denne MA, Miravet L. Relationship between bone GLA-protein (BGP) and calcidiol (25-hydroxycalciferol) in serum of breast-fed infants. Endocrinol Exp. 1986;20(2-3):329-34.
Le Boulch N, M. Cancela L, Miravet L. Calcidiol in human milk. The effect of prohormone on vitamin D status of breast fed unsupplemented infants. Endocrinol Exp. 1986;20(2-3):325-8.
M. Cancela L, Le Boulch N, Miravet L. Relationship between the vitamin D content of maternal milk and the vitamin D status of nursing women and breast-fed infants. J Endocrinol. 1986;110(1):43-50.
Le Boulch N, M. Cancela L, Miravet L, Lange C. Assessment of vitamin D sulphate in human milk using desorption chemical ionization mass spectrometry. Biomed Environ Mass Spectrom. 1986;13(2):53-6.
M. Cancela L, Marie PJ, Le Boulch N, Miravet L. Influence of vitamin D on mineral metabolism, hormonal status and bone histology in lactating rats and their pups. J Endocrinol. 1985;105(3):303-9.
Rebut-Bonneton C, Demignon J, M. Cancela L, Miravet L. Effect of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 maternal loads on maternal and fetal vitamin D metabolite levels in the rat. Reprod Nutr Dev. 1985;25(3):583-90.
Boulch NL, M. Cancela L, Miravet L. Cholecalciferol sulfate identification in human milk by HPLC. Steroids. 1982;39(4):391-8.
de Vernejoul MC, Girot R, Gueris J, et al. Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia. J Clin Endocrinol Metab. 1982;54(2):276-81. doi:10.1210/jcem-54-2-276
Projetos
Eventos
Tipo de Evento 
Seminário
Neste seminário, o nosso investigador Vincent Laizé irá apresentar uma visão geral sobre a cultura de células de peixes.
Qua, 02/06/2021
Local 
Online | Zoom platform
Tipo de Evento 
Seminário
Marco Tarasco irá falar sobre a utilização de ferramentas de análise de imagem em sistemas de peixe zebra in vivo para avaliar o efeito tóxico de poluentes ambientais no desenvolvimento do esqueleto...
Qua, 17/03/2021
Tipo de Evento 
Outros Eventos
Esta sexta-feira, o aluno de mestrado Michele Loiodice, irá apresentar e defender a sua tese na Universidade do Algarve às 14:00h.
Sex, 08/11/2019
Tipo de Evento 
Outros Eventos
Esta sexta-feira, a nossa doutoranda Patrícia Diogo irá defender a sua tese sobre cryopreservation of zebrafish germ cells.
Sex, 18/10/2019
Local 
Anfiteatro Verde, Edf 8
Tipo de Evento 
Evento Científico
We thank all participants for joining us at IAFSB, thus making this conference possible. IAFSB conferences would also not be possible without many hours of volunteer work of the local organising...
Seg, 16/04/2018 a Qui, 19/04/2018
Local 
Hotel Vila Galé Albacora, Tavira, Algarve, Portugal
21st April 2017 Organization: CCMAR Location: Universidade do Algarve - Campus de Gambelas (limited places)
Sex, 21/04/2017
Local 
CCMAR - Universidade do Algarve - Campus de Gambelas (Faro)
Tipo de Evento 
Seminário
This wednesday, we will receive Gil Martins (CCMAR) and Aldric Negrier (Reprapalgarve). Don't miss this seminar and the opportunity to get to know about 3D printers and all the potential to use it...
Qua, 08/03/2017
Local 
Anf. 1.8 (bdg 8) - Gambelas Campus UAlg
Tipo de Evento 
Seminário
CCMAR SEMINARS 8th FEB | 13:30 | Anf. 1.8 (Edf. 8) Vitamin K in Fish Skeletal Biology Paulo Gavaia (CCMAR - BIOSKEL) Poster Abstract Vitamin K (VK) is a fat soluble vitamin discovered by Henrik Dam...
Qua, 08/02/2017
Local 
Anf. 1.8 (edf. 8) - Gambelas Campus UAlg
This course was designed to provide basic knowledge on the use of the biological model zebrafish with main emphasis on its use in the context of the study of human diseases and biomedical sciences...
Qui, 12/05/2016
Tipo de Evento 
Evento Científico
The fourth conference “Interdisciplinary Approaches in Fish Skeletal Biology” took place in Tavira, Portugal, April 27-30, 2015.
Seg, 27/04/2015 a Qui, 30/04/2015
Local 
Tavira, Algarve, Portugal
Tipo de Evento 
Evento Científico
Seg, 22/04/2013 a Qua, 24/04/2013
Local 
Tavira, Algarve, Portugal
Tipo de Evento 
Evento Científico
O "II Interdisciplinary Approaches in Fish Skeletal Biology" Workshop pretende juntar especialistas de várias disciplinas científicas, relacionadas com a biologia do esqueleto dos peixes.
Ter, 26/04/2011 a Qui, 28/04/2011
Local 
Tavira, Algarve, Portugal
Tipo de Evento 
Evento Científico
Seg, 27/04/2009 a Qua, 29/04/2009
Local 
Tavira, Algarve, Portugal
Notícias
News 
Com mais esta descoberta, os investigadores acreditam estar cada vez mais perto de novas terapêuticas para doenças ósseas como a osteoporose, que é caraterizada pela perda de massa óssea. O trabalho recentemente publicado pelos...
"O peixe zebra consegue regenerar a sua barbatana caudal, apesar desta ser feita de tecido e osso como os membros dos demais animais e, claro, dos seres humanos. Uma particularidade que foi investigada pelo grupo Bioskel, do...
The network “Strategies of development and improvement of the production of fish larvae in Iberoamerica” (Network CYTED LARVAplus) has organized the kickoff meeting at the Omar Dengo Campus from Universidad Nacional (UNA, Costa...
O CCMAR organiza esta semana a 5ª edição da Conferência “Interdisciplinary Approaches in Fish Skeletal Biology (IAFSB)” em Tavira, Portugal.
Débora Varela is collaborating with the Bioskel Group at CCMAR. Welcome Débora!
Daniela de Castro irá juntar-se ao grupo Bioskel, onde irá preparar a sua tese de mestrado sobre microalgas.