Comparative genomics, comparative endocrinology, evolutionary biology, molecular biology, bioinformatics and cell signaling of GPCRs in metazoans. Domain of several in silico tools, data mining approaches and ligand-binding screening cell in vitro assays. Establishment of comparative evolutionary models for GPCR evolution in invertebrates and vertebrates and identification of novel members.
Publications:
1. On JSW, Su L, Shen H, Arokiaraj AWR, Cardoso JCR, Li G, Chow BKC (2022). PACAP/GCGa Is an Important Modulator of the Amphioxus CNS-Hatschek’s Pit Axis, the Homolog of the Vertebrate Hypothalamic-Pituitary Axis in the Basal Chordates. Front Endocrinol., 14 April 2022 https://doi.org/10.3389/fendo.2022.850040
2. Peng M, Li Z, Cardoso JCR, Niua D, Dongc LX, Li J, Power DM (2022). Domain-dependent evolution explains functional homology of protostome and deuterostome complement C3-like proteins. Front Immunol. 10 https://doi.org/10.3389/fimmu.2022.840861
3. 1. Sousa CSV, Fernandes SA, Cardoso, JCR, Wang Y, Zhai W, Guerreiro PM, Chen, L, Canário AVM, Power DM (2022). Toll-like receptor evolution: does temperature matter? Front Immunol, 27. https://doi.org/10.3389/fimmu.2022.812890 H-index 155
4. Sania RE, Cardoso JCR, Louro B, Marquet M, Canário AVM (2021). A new subfamily of ionotropic glutamate receptors unique to the echinoderms with putative sensory role. Mol Ecol. Dec;30(24):6642-6658. https://doi.10.1111/mec.16206.
5. Li Z, Cardoso JCR, Peng M, Inácio JPS, Power DM. (2021). Evolution and potential function in molluscs of neuropeptide and receptor homologues of the insect allatostatins. Front Endocrinol. https://doi.org/10.3389/fendo.2021.725022 H-index 83
6. Najafpour B, Cardoso JCR, Canário AVM, Power DM. (2020). Specific evolution and gene family expansion of complement 3 and regulatory factor H in fish. Front Immunol. (https://doi.org/10.3389/fimmu.2020.568631
7. Li L, Cardoso JCR, Félix RC, Mateus AP, Canário AVM, Power DM (2021). Fish lysozyme gene family evolution and divergent function in early development. Dev Comp Immunol. 114, 103772. https://doi.org/10.1016/j.dci.2020.103772
8. Clark MS, Peck LS, Arivalagan J, Backeljau T, Berland S, Cardoso JCR, et al. (2020). Deciphering mollusc shell production: the roles of genetic mechanisms through to ecology, aquaculture and biomimetics. Biol Rev. https://doi.org/10.1111/brv.12640
9. Cardoso JCR, Bergqvist CA, Larhammar D. (2020). Corticotropin-Releasing Hormone (CRH) Gene Family Duplications in Lampreys Correlate With Two Early Vertebrate Genome Doubling. Front Neurosci. (https://doi.org/10.3389/fnins.2020.00672)
10. Cardoso JCR, Félix RC, Ferreira V, Peng M, Zhang X, Power DM (2020). The calcitonin-like system is an ancient regulatory system of biomineralization Sci Rep. 10, 7581. https://doi.org/10.1038/s41598-020-64118-w.
11. Cardoso JCR, Garrido G, Power DM (2020). Tracing the origins of the Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP). Front Neurosci. 14:366. https://doi.org/10.3389/fnins.2020.00366.
12. Marquet N, Cardoso JCR, Louro B, Fernandes SA, Silva SC, Canário AVM (2020). Holothurians have a reduced GPCR and odorant receptor-like repertoire compared to other echinoderms. Sci Rep. Feb 25;10(1):3348. https://doi.org/10.1038/s41598-020-60167-3
13. Letsiou S, Félix RC, Cardoso JCR; Anjos L, Mestre ALG, Gomes HL, Power DM (2020). Cartilage acidic protein 1 promotes increased cell viability, cell proliferation and energy metabolism in primary human dermal fibroblasts. Biochimie. 171-172:72-78. https://doi.org/10.1016/j.biochi.2020.02.008
14. Li Y-F, Cheng Y-L; Ke C, Cheng Z-Y, Zhu X, Cardoso JCR, Liang X, Zhu Y-T, Power DM, Yang J-L (2020). Thyroid Hormone Receptor: A New Player in Epinephrine-induced Larval Metamorphosis of the Hard-shelled Mussel. Gen Comp Endocrinol. Feb 1; 287 :113347. https://doi.org/10.1016/j.ygcen.2019.113347.
15. Sillanpää JK, Cardoso JCR, Félix RC, Anjos L, Power DM, Sundell K (2020). Dilution of Seawater Affects the Ca2+ Transport in the Outer Mantle Epithelium of Crassostrea gigas. Front Physiol. 2020 Jan 22;11:1. https://doi.org/10.3389/fphys.2020.00001
16. Costa P, Schein V, Rafael Z, Santos AS, Kliemann LM, Nunes FB, Cardoso JCR, Félix RC, Canário AVM, Brum IS, Branchini G (2020). Stanniocalcin-1 protein expression profile and mechanisms in proliferation and cell death pathways in prostate cancer. Mol Cell Endocrinol. 15; 502:110659. https://doi.org/10.1016/j.mce.2019.110659
17. Cardoso, JCR, Ferreira V, Zhang X, Anjos L, Félix RC, Batista FM, Power DM (2019). Evolution and diversity of alpha-carbonic anhydrases in the mantle of the Mediterranean mussel (Mytilus galloprovincialis). Sci. Rep. 9 (1). http://dx.doi.org/10.1038/s41598-019-46913-2
18. Li Y-F, Liu Y-Z, Chen Y-W, Chen K, Batista FM, Cardoso JCR, Chen Y-R, et al. (2019). Two toll-like receptors identified in the mantle of Mytilus coruscus are abundant in haemocytes. Fish & Shellfish Immunology 90: 134-140. http://dx.doi.org/10.1016/j.fsi.2019.05.001
19. Marques J, Cardoso JCR, Felix RC, Santana RAG, Guerra, MGB. Power DM, Silveira, H (2018). Freshblood-free diet for rearing malaria mosquito vectors. Sci. Rep. 8 (1). http://dx.doi.org/10.1038/s41598-018-35886-3.
20. Parreira B, Cardoso JCR, Costa, Rita; Couto, Ana Rita; Bruges-Armas, Jácome; Power, Deborah M. (2018). Persistence of the ABCC6 genes and the emergence of the bony skeleton in vertebrates. Sci. Rep. 8 (1). http://dx.doi.org/10.1038/s41598-018-24370-7.
21. Cardoso JCR, Félix RC, Costa C, Palma PFS, Canário AVM, Power DM (2018). Evolution of the glucagon-like system across fish. Gen Comp Endocrinol. Aug 1;264:113-130. https://doi.org/10.1016/j.ygcen.2017.10.003.
22. Filipe AIR, Cardoso JCR, Miguel G, Anjos L, Trindade H, Figueiredo AC, Barroso J, Power DM, Marques NT (2017). Molecular cloning and functional characterization of a monoterpene synthase isolated from the aromatic wild shrub (Thymus albicans). J Plant Physiol. Nov;218:35-44. https://doi.org/10.1016/j.jplph.2017.07.013.
23. Mateus AP, Anjos L, Cardoso JCR, Power DM (2017). Chronic stress impairs the local immune response during cutaneous repair in gilthead sea bream (Sparus aurata, L.). Mol Immunol. 87:267-283. https://doi.org/10.1016/j.molimm.2017.04.008.
24. Mateus AP, Costa R, Cardoso JCR, Andree KB, Estévez A, Gisbert E, Power DM (2017). Thermal imprinting modifies adult stress and innate immune responsiveness in the teleost sea bream. J Endocrinol. 233(3):381-394. https://doi.org/10.1530/JOE-16-0610.
25. Costa RA, Cardoso JCR and Power DM (2017). Evolution of the angiopoietin-like gene family in teleosts and their role in skin regeneration. BMC Evol Biol; 17: 14. https://doi.org/10.1186/s12862-016-0859-x.
26. Alves RN, Cardoso JCR, Harbor T, Martins RST, Manchado M, Norbert B, Power DM (2017). Duplication of Dio3 genes in teleost fish and their divergent expression in skin during flatfish metamorphosis. Gen. Comp. Endocrinol. 246, 279-293. https://doi.org/10.1016/j.ygcen.2017.01.002.
27. Anjos L, Morgado I, Guerreiro M, Cardoso JC, Melo EP, Power DM (2017). Cartilage Acidic Protein 1 (CRTAC1), a new member of the beta-propeller protein family with amyloid propensity: CRTAC1 proteins and their amyloid propensity. Proteins. 85 (2):242-255. https://doi.org/10.1002/prot.25210.
28. Cardoso JCR, Christina A. Bergqvist CA, Félix RC, Larhammar D. (2016). Corticotropin-releasing hormone family evolution; five ancestral genes remain in some lineages. J Mol Endocrinol. Jul;57(1):73-86. http://dx.doi.org/10.1530/JME-16-0051.
29. Cardoso JCR, Félix RC, Bjärnmark N, Power DM (2016). Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function. Mar Genomics; 27:25-35. https://doi.org/10.1016/j.margen.2015.12.003.
30. Félix RC, Trindade M, Pires IR, Fonseca VG, Martins RS, Silveira H, Power DM, Cardoso JCR (2015). Unravelling the Evolution of the Allatostatin-Type A, KISS and Galanin Peptide-Receptor Gene Families in Bilaterians: Insights from Anopheles Mosquitoes. PLOS ONE 10 (7): e0130347. https://doi.org/10.1371/journal.pone.0130347.
31. Cardoso JCR, Félix RC, Martins RS, Trindade M, Fonseca VG, Fuentes J, Power DM (2015). PACAP system evolution and its role in melanophore function in teleost fish skin. Mol Cell Endocrinol. Mar 5; 403: 78-87 https://doi.org/10.1016/j.mce.2015.04.020.
32. Terra SR, Cardoso JCR, Félix RC, Martins LAM, Souza DOG, Guma FCR, Canário AVM, Schein V (2015). STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition. Molecular and Cellular Endocrinology Mol Cell Endocrinol. Mar 5;403:78-87. https://doi.org/10.1016/j.mce.2015.01.010.
33. Cardoso JCR, Larhammar D (2014). Comparative evolution of peptide hormone-binding GPCRs: A route to understanding functional complexity. Gen Comp Endocrinol. Dec 1; 209 :1-2 https://doi.org/10.1016/j.ygcen.2014.10.001.
34. Cardoso JCR, Félix RC, Bergqvist C, Larhammar D (2014). New insights into the evolution of vertebrate CRH (corticotropin-releasing hormone) and invertebrate DH44 (diuretic hormone 44) receptors in metazoans. Gen Comp Endocrinol. Dec 1;209:162-70 https://doi.org/10.1016/j.ygcen.2014.09.004.
35. Cardoso JCR, Félix RC, Trindade M, Power DM (2014). Fish genomes provide novel insights into the evolution of vertebrate secretin receptors and their ligand. Gen Comp Endocrinol Dec 1;209:82-92 https://doi.org/10.1016/j.ygcen.2014.05.025.
36. Cardoso JCR, Félix RC, Power DM (2014). Nematode and Arthropod Genomes Provide New Insights into the Evolution of Family 2 GPCRs. PLOS ONE; 9(3): e92220. https://doi.org/10.1371/journal.pone.0092220.
37. Nevalainen TJ, Morgado I, Cardoso JCR (2013). Identification of novel phospholipase A2 group IX members in metazoans. Biochimie Aug;95(8):1534-43. https://doi.org/10.1016/j.biochi.2013.04.003.
38. Cardoso JCR, Félix RC, Fonseca VG, Power DM (2012). Feeding and the rhodopsin family g-protein coupled receptors in nematodes and arthropods. Front Endocrinol. 3:157. https://doi.org/10.3389/fendo.2012.00157
39. Nevalainen TJ, Cardoso JCR (2012). Conservation of group XII phospholipase A2 from bacteria to human. Comp. Biochem. Physiol.Part D Dec;7(4):340-50. https://doi.org/10.1016/j.cbd.2012.07.002.
40. Pinheiro PLC, Cardoso JCR, Power DM, Canário AVM (2012). Functional characterization and evolution of PTH/PTHrP receptors: insights from the chicken. BMC Evol Biol. Jul 6;12:110. https://doi.org/10.1186/1471-2148-12-110.
41. Nevalainen TJ, Cardoso JCR, Riikonen PT (2012). Conserved domains and evolution of secreted phospholipase A2. FEBS Journal, 279, Issue 4,636-49. https://doi.org/10.1111/j.1742-4658.2011.08453.x.
42. Schein V, Cardoso JCR, Pinto PIS, Anjos L, Silva N, Power DM, Canário AVM (2012). Four stanniocalcin genes in teleost fish: Structure, phylogenetic analysis, tissue distribution and expression during hypercalcemic challenge. Gen Comp Endocrinol 175, 344–356 https://doi.org/10.1016/j.ygcen.2011.11.033.
43. Cardoso JCR, Laiz-Carrion R, Louro B, Silva N, Canario AVM, Mancera JM, Power DM (2011). Divergence of Duplicate POMC Genes in gilthead seabream Sparus auratus. Gen Comp Endocrinol Sep 15;173(3):396-404. https://doi.org/10.1016/j.ygcen.2010.12.001.
44. Pinheiro PLC, Cardoso JCR, Gomes AS, Fuentes J, Power DM, Canário AVM (2010). Gene structure, transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken. BMC Evol Biol, 10:373 https://doi.org/10.1186/1471-2148-10-373.
45. Clark MS, Thorne M, Vieira FA, Cardoso JCR, Power DM, Peck LS (2010). Insights into shell deposition in the Antarctic bivalve Laternula elliptica: gene discovery in the mantle transcriptome using 454 pyrosequencing. BMC Genomics, 11:362 https://doi.org/10.1186/1471-2164-11-362.
46. Cardoso JCR, Vieira FA, Gomes AS, Power DM (2010). The serendipitous origin of chordate secretin peptide family members. BMC Evol Biol, 10:135 https://doi.org/10.1186/1471-2148-10-135.
47. Cardoso JCR, de Vet E, Louro B, Elgar G, Clark MS, Power DM (2007). Persistence of duplicated PAC1 receptor genes in the teleost fish sea bream (Sparus auratus). BMC Evol Biol. 2007 Nov 12;7:221. https://doi.org/10.1186/1471-2148-7-221.
48. Cardoso JCR, Vieira FA, Gomes AS, Power DM (2007). PACAP, VIP and their receptors in the metazoa: Insights about the origin and evolution of the ligand-receptor pair. Peptides, 28 (9) 1902-1919. https://doi.org/10.1016/j.peptides.2007.05.016
49. Cardoso JCR, Pinto VC, Vieira FA, Clark MS, Power DM (2006). Evolution of secretin family GPCR members in the metazoa. BMC Evol Biol. Dec 13;6:108. https://doi.org/10.1186/1471-2148-6-108.
50. Cardoso JCR, Power DM, Clark MS (2005). Comparative study of family 2 GPCRs in Fugu rubripes. Ann New York Acad Sciences, April; 1040: 257-260 https://doi.org/10.1196/annals.1327.037.
51. Cardoso JCR, Clark MS, Bridge P, Gilles A, Power DM (2005). The secretin G-protein coupled receptor family: teleost receptors. J Mol Endocrinol. Jun;34(3):753-65. https://doi.org/10.1677/jme.1.01730.
52. Santos CRA, Estêvão MD, Fuentes J, Cardoso JCR, Fabra M, Detmers FJ, Deen PMT, Cerdà J, Power DM (2004). Isolation of a novel aquaglyceroporin from a marine teleost (Sparus auratus): Function and tissue distribution. J Exp Biol. Mar;207(Pt 7):1217-27. https://doi.org/10.1242/jeb.00867.
53. Cardoso JCR, Power DM, Elgar G, Clark MS (2004). Duplicated receptors for VIP and PACAP in a teleost fish, Fugu rubripes. J Mol Endocrinol. Oct;33(2):411-28. https://doi.org/10.1677/jme.1.01575.
54. Cardoso JCR, Power DM, Elgar G, Clark MS (2003). Genomic Characterisation of putative growth hormone releasing hormone (GHRH) receptor genes in the teleost fish Fugu rubripes. DNA sequence, 14 (2): 129-133. https://doi.org/10.1080/1042517031000081142.
55. Cardoso JCR, Power DM, Elgar G, Clark MS (2003). Isolation and characterisation of corticotrophin releasing factor (CRF1) receptor 1 gene in a teleost fish Fugu rubripes. DNA sequence, 14 (3): 215-21. https://doi.org/10.1080/1042517031000112624.
